🧬 Category

q-bio

3724 papers

🧬 biology

Only a third of Fusarium oxysporum formae speciales are monophyletic: a per-label and per-deposit audit of 363 public genomes

By auditing 363 public *Fusarium oxysporum* genomes, this study reveals that only one-third of formae speciales are monophyletic and that the current classification system is plagued by significant phylogenetic conflicts, taxonomic redundancy, and mislabeled or non-target genomes, arguing that *forma specialis* should be treated as an operational pathological category requiring independent evidence rather than a phylogenetic one.

Beyza Akal, Yasin Kaymaz2026-09-17
🧬 biology

Quantifying the impact of experimental hut design on intervention evaluation outcomes and predicted reductions in vectorial capacity

This study demonstrates that experimental hut design significantly influences mosquito behavior and the predicted reduction in vectorial capacity for insecticide-treated nets, highlighting the critical need to account for structural variations in trial data when forecasting population-level transmission impacts.

Emma Louise Fairbanks, Alphonce Assenga, Olukayode G Odufuwa, Raphael N'Guessan, Jason Moore, Sarah J Moore2026-09-17
🧬 biology

The STAU1-CD44v8-10 axis regulates the initiation and progression of lung squamous cell carcinoma through PI3K/AKT signaling

This study demonstrates that the STAU1–CD44v8-10 axis drives the initiation and progression of lung squamous cell carcinoma by sustaining PI3K/AKT signaling, a process triggered by cigarette smoke exposure that promotes malignant traits and poor patient prognosis.

lingrui shang, Shisheng Jiang, Nannan Wang, Qianqian Liu, Yimei chen, Tongran Zhang, Yun-shen Chan, Wenzhao zhong, feng (…)2026-09-17
🧬 biology

From resilient adults to fragile early life stages: salinity tolerance across the life cycle of the green panchax, Aplocheilus blockii

This study reveals that while the green panchax (*Aplocheilus blockii*) exhibits remarkable salinity tolerance as an adult, particularly under gradual acclimation, its early life stages are significantly more vulnerable, suggesting that recruitment in this species is primarily constrained by the salinity sensitivity of embryos and larvae.

Grace George, S. Thiruvarasu, Binu Varghese2026-09-17
🧬 biology

Study on Segmental Alterations in Brain White Matter Fibers in Children with Sensorineural Hearing Loss Using Automated Fiber Quantification

This study utilizes automated fiber quantification on diffusion tensor imaging to identify specific white matter fiber segment alterations in children with sensorineural hearing loss, revealing age-dependent differences in auditory compensation and pinpointing distinct tract nodes as potential imaging biomarkers for predicting cochlear implant outcomes.

Nan Sun, Wenzhuo Cui, Boyu Chen, Yalian Yu, Shanshan Wang2026-09-17
🧬 biology

Four-dimensional Gaussian adaptive tomography for aberration-corrected, time-lapse 3D imaging using Fourier light-field microscopy

This paper introduces 4D Gaussian adaptive tomography (4DGAT), a physics-informed framework that combines a self-calibrating forward model with a temporally deformable 3D Gaussian representation to enable robust, aberration-corrected, and temporally consistent four-dimensional imaging of biological dynamics across subcellular, organ, and single-cell scales using Fourier light-field microscopy.

Ning Gu, Zhouyu Jin, Bo Xiong, Linyuan Wu, Meiyue Wang, Chenyu Xu, Xun Cao, You Zhou2026-09-17
🧬 biology

Early retinal microglial activation and ganglion cell dysfunction following severe traumatic brain injury in mice

This study demonstrates that severe traumatic brain injury in mice rapidly triggers retinal microglial activation, caspase-3-mediated apoptosis, and transient ganglion cell dysfunction within 48 hours, highlighting the retina as a sensitive early indicator of CNS neurodegeneration.

Loretta Péntek, Endre Czeiter, Krisztina Amrein, András Szentiványi, Balázs Kovács, Boglárka Balogh, Gergely Szarka, Lil (…)2026-09-17
🧬 biology

Examining the composition of gut microbiota in a South African population: a comparative study between type 2 diabetes mellitus patients and non-diabetic individuals

This cross-sectional study of South African individuals reveals that type 2 diabetes patients exhibit significantly lower gut microbial diversity and distinct compositional shifts, including an enrichment of specific taxa like *Escherichia-Shigella* and *Bacteroides* alongside a depletion of beneficial groups such as *Prevotella_9* and *Faecalibacterium*, compared to non-diabetic controls.

Sara Mosima Pheeha, Justice T Ngom, Abhinav Sharma, Bettina Chale-Matsau, Kristien Nel Van Zyl, Samuel Manda, Peter Suwi (…)2026-09-17
🧬 biology

A five-gene prognostic signature integrating endothelial senescence and lipid metabolism for risk stratification in hepatocellular carcinoma

This study establishes and validates a five-gene prognostic signature (FABP5, FABP6, MMP1, SGPP2, UGT1A10) for hepatocellular carcinoma by integrating endothelial senescence and lipid metabolism mechanisms, revealing hepatocyte-specific expression, stage-dependent dynamics, and a critical role for FABP5 in linking metabolic reprogramming with immune microenvironment remodeling via the NAMPT–(ITGA5 + ITGB1) signaling axis.

Maoyun Xie, Zhiqun Lin, Hu Zeng, Lianhai Li, Liping Liu2026-09-17