1390 papers
This study constructs the first spatiotemporal proteomic atlas of *Haematococcus pluvialis* lipid droplets, revealing that stage-specific protein remodeling drives astaxanthin accumulation through a conserved two-step sequestration model that integrates multi-organelle functions for carbon repartitioning and redox homeostasis.
Using Adolescent Brain Cognitive Development data, this study finds that entering puberty significantly widens the dual systems imbalance gap (increasing sensation-seeking while decreasing impulse control) for male youth without autism, whereas this pubertal effect is attenuated in males with autism, while no significant effects were observed for female youth.
This paper proposes the parameter-free Life-Ratios Hypothesis, which uses dimensionless thermodynamic constraints to define a continuous habitability corridor for DNA-based life across water-ammonia mixtures, predicting an optimal temperature of 226 K for ammonia and explicitly excluding warm ammonia-based biospheres.
This study integrates metabolomics and proteomics data to reveal that dysregulation in complement/coagulation cascades, extracellular matrix interactions, and metabolic pathways converges on uteroplacental hypoperfusion, thereby elucidating the molecular mechanisms underlying recurrent spontaneous abortion.
Using functional near-infrared spectroscopy, this study demonstrates that basketball experts exhibit superior instantaneous decision-making accuracy linked to a spatiotemporally specific neural efficiency pattern characterized by reduced ventrolateral prefrontal cortex activation, particularly during the mid-task phase, contrasting with the inefficient cognitive compensation observed in novices.
This study demonstrates that IGF-II exerts neuroprotective effects in Parkinson's disease models by activating the SphK1/S1P/S1P1 signaling axis, which preserves mitochondrial function, enhances antioxidant defenses, and reduces α-synuclein accumulation.
This paper introduces Embodied Self-Supervised Learning (E-SSL), a model that leverages temporal consistency and sensorimotor contingencies from natural human interaction to generate high-level semantic visual representations that outperform existing models, align more closely with pre-verbal children's visual cortex, and offer new insights into the origins of human visual development and stream specialization.
This study utilizes an immunoinformatics approach to design and computationally evaluate a domain-based vaccine targeting the M segment of the Crimean-Congo hemorrhagic fever virus, which demonstrated a strong predicted immune response but requires further experimental validation.
This study reveals that while a gluten-free diet partially normalizes the faecal metabolome in children with coeliac disease, distinct metabolic alterations in bile acid, sterol, and microbial pathways persist, suggesting ongoing gut dysfunction and offering potential non-invasive biomarkers for disease monitoring.
By applying a positive-unlabeled machine-learning framework to integrate species traits, taxonomy, and environmental data, this study reconstructs a global probabilistic marine fish food web that reveals a vast, structured network of previously undocumented interactions, fundamentally shifting the understanding of marine trophic architecture from sparse to densely connected and suggesting that ecosystems are more resilient than empirical records indicate.