🧬 Category

q-bio

1390 papers

🧬 biology

Transcriptional benchmarking of human monocyte-derived microglia-like cells and iPSC-derived microglia reveals distinct immune-alert and homeostatic programmes

This study systematically benchmarks the transcriptional and functional profiles of various human microglial models, revealing that while iPSC-derived microglia best mimic homeostatic brain states and monocyte-derived cells retain immune-alert signatures, 3D culture conditions can partially shift monocyte-derived cells toward a more tissue-adapted phenotype despite their distinct origins.

Hazel Quek, Fazeleh Etebar, Carla Cuní-López, Jamie R. Kutasovic, Romal Stewart, Yi Chieh Lim, Tara L. Roberts, Anthony (…)2026-07-28
🧬 biology

Regulatory Integration, Multistability, and Organizational-State Transitions in Biological Systems

This study proposes a bioevo-cybernetic framework demonstrating that increasing regulatory integration drives biological systems toward multistability and organizational-state transitions through attractor-landscape restructuring, a theoretical principle empirically supported by a monotonic increase in regulatory integration estimates across the evolutionary gradient from prokaryotes to humans.

Zuchang Pei2026-07-28
🧬 biology

Ultrafine amorphous silica induces chronic lung epithelial cell stress and pro-fibrotic reprogramming in a particle size‑ and exposure duration‑dependent manner

This study demonstrates that chronic, low-dose exposure to ultrafine amorphous silica induces persistent cellular stress and pro-fibrotic reprogramming in lung epithelial cells in a particle size- and duration-dependent manner, challenging the assumption that amorphous silica is a safe alternative to crystalline silica.

Ellen Donohoe, Sakthi Priya Selvamani, Vivek Dharwal, Thomas R. O’Neil, Richard Zelei, Andrew N. Harman, Sharyn Gaskin (…)2026-07-28
🧬 biology

Integrated Multi-Omics and Network-Based Identification of Prognostic Cell-Cycle Hub Genes in Lung cancer

This study integrates multi-omics and network analyses of lung cancer transcriptomic data to identify four cell-cycle-related hub genes (CDK1, CCNB1, CCNA2, and TOP2A) that exhibit significant genetic alterations, correlate with immune cell infiltration, and serve as robust prognostic biomarkers associated with poor patient survival.

Saba Ehsan, Anupriya Chaudhary, Divya Mishra, Supriya Maurya, Mohan P. Singh2026-07-28
🧬 biology

BCG vaccination attenuates Schistosoma mansoni-associated rural–urban immune variation

This study demonstrates that BCG revaccination can partially reverse the chronic immune stimulation and exhaustion signatures caused by *Schistosoma mansoni* infection in rural Ugandan adolescents, thereby narrowing the immune disparities observed between rural and urban populations.

Gyaviira Nkurunungi, Marion König, Bridgious Walusimbi, Jacent Nassuuna, Yoanne D. Mouwenda, Emily L. Webb, Mikhael D. M (…)2026-07-28
🧬 biology

Proton motive force dissipation drives flavodiiron proteins to the thylakoid membrane for ferredoxin-powered O2 photoreduction

This study reveals that in cyanobacteria, the dissipation of proton motive force recruits flavodiiron proteins to the thylakoid membrane where they utilize Ferredoxin-1 to reduce oxygen, establishing a self-feedback mechanism that dynamically regulates photosynthetic electron flow.

Lauri Nikkanen, Serhii Vakal, Anita Santana-Sánchez, Michal Hubacek, Yingying Wang, Marko Böhm, Kirstin Gutekunst, Tiina (…)2026-07-28