🧬 Category

q-bio

1390 papers

🧬 biology

A Diagnostic Framework for Auditing Validation-Driven Adaptive Reward Weighting in Molecular Generation

This paper introduces a rigorous diagnostic framework for auditing adaptive reward weighting in molecular generation that, when applied to a locked REINVENT4 experiment, reveals that the tested controller failed to demonstrate practically meaningful improvements over static baselines despite appearing successful in development, thereby establishing a reusable template for separating genuine signal from temporal noise and oracle artifacts.

wei liao, chensen zhang2026-07-28
🧬 biology

Sulforaphane, a Mustard Oil Bomb Product, Reprograms Herbivore Gene Expression by Altering Chromatin Structure Across Generations

This study demonstrates that sulforaphane, a natural HDAC inhibitor produced by cruciferous plants, alters chromatin accessibility and reprograms gene expression in herbivorous insects, causing developmental delays and inducing intergenerational epigenetic effects in offspring that were never directly exposed to the compound.

Thomas M Arnold, Dana J Somers, David B Kushner, MARISA ARREOLA, WHITNEY FINNEY, ASHLEY GROFF, ANNIKA HAAGENSEN, MEL MOR (…)2026-07-28
🧬 biology

Antipsychotics Chlorpromazine and Clozapine Inhibit Membrane Fusion Through Direct Interaction with Lipid Bilayers

This study demonstrates that the antipsychotics chlorpromazine and clozapine, but not amisulpride, directly interact with lipid bilayers to inhibit membrane fusion and vesicle exocytosis, suggesting a membrane-dependent mechanism that complements their canonical dopamine D2 receptor antagonism.

Hugo Fumat, Vladimir Adrien, Sébastien Nola, Kristina Niort, Thierry Galli, Philippe Nuss, David TARESTE2026-07-28
🧬 biology

System-level analysis of gene, pathway and phytochemical associations with psoriasis

This study utilizes a system-level analysis of gene activity in psoriatic skin to identify key inflammatory pathways and regulators, ultimately shortlisting seven plant-derived compounds—particularly protopine and atractylon—as promising multi-target therapeutic candidates for psoriasis that require further experimental validation.

Sonalika Ray, Ojasvi Dutta, Neoklis Apostolopoulos, Konstantin G. Kousoulas, Jean Christopher Chamcheu, Rishemjit Kaur2026-07-28
🧬 biology

Warming, nitrogen addition, and provenance regulate responses of plant leaf and stem traits of Solidago canadensis to rhizosphere edaphic properties

This study demonstrates that a decade of warming and nitrogen addition, interacting with plant provenance, regulates the leaf and stem traits of *Solidago canadensis* primarily through soil available potassium and nitrate nitrogen, revealing the invasive provenance's stronger adaptive capacity under future climate change.

Jingji Li, Jianxin Ren, Juanjuan Li, Peihao Peng, Xiaohui Zhou2026-07-28
🧬 biology

Integrated transcriptomic and single-cell RNA sequencing analyses reveal shared immune–metabolic dysregulation between coronary heart disease and non-alcoholic fatty liver disease

This study integrates transcriptomic and single-cell RNA sequencing analyses to identify shared immune–metabolic dysregulation between coronary heart disease and non-alcoholic fatty liver disease, highlighting five key hub genes (FOXO1, SIK1, IER3, BIRC3, and NUPR1) and altered macrophage-mediated cell communication as critical mechanisms underlying their comorbidity.

LI ZHANG, HONG GU, YiBIN ZHU, LULU TANG, JIAXING AN, JIAXING ZHU, HAI JIN, BIGUANG TUO2026-07-28
🧬 biology

Complete POR ablation in human adrenal cells reveals steroidogenic rerouting and variant-dependent loss of cytochrome P450 support

Using CRISPR/Cas9 to generate complete POR knockout in human adrenal and kidney cells, this study reveals that while canonical steroidogenesis is blocked, low-level DHEA synthesis persists via alternative routes, and specific disease-associated variants like P228L exhibit distinct, enzyme-selective functional deficits that are best characterized under endogenous regulatory control.

Amit Pandey, Anna Matveeva, Jibira Yakubu, Therina du Toit2026-07-28
🧬 biology

Published benchmark AUROC does not predict generalisation: an independent evaluation of protein solubility predictors on native and heterologous E. coli proteins

This study demonstrates that published benchmark AUROCs are poor predictors of a protein solubility model's generalization performance on independent distributions, revealing that state-of-the-art deep learning models can underperform simple interpretable baselines when applied outside their specific training domains.

Jakob Oeschey2026-07-28
🧬 biology

Acetate, a short-chain fatty acid, inhibits Coxiella burnetii replication via direct bacteriostatic effect and through vacuolar modulation and host cell perturbations

This study demonstrates that the short-chain fatty acid acetate inhibits *Coxiella burnetii* replication through a combination of direct bacteriostatic effects, disruption of the acidic intracellular niche via vacuolar pH elevation and size reduction, and broad reprogramming of host cell transcriptional pathways.

Yazen Germukly, Ashley Davis, Brooke A. Hall, Vijitha D. Kantety, Alexandria Q. Sandelin, Dhritiman Samanta2026-07-28