5759 papers
This study employs a machine-learning classifier to analyze 41 *Vibrio coralliilyticus* genomes, revealing that while chromosomes share similar core gene proportions, they exhibit distinct functional specializations, and highlighting the complementary evolutionary roles of chromosomes and diverse megaplasmid lineages in environmental adaptation.
This study integrates multi-environment phenotyping and whole-genome resequencing of sorghum to identify specific SNPs and haplotypes, particularly on chromosomes 5 and 9, that govern biomass-based water and nitrogen productivity, revealing genetically tractable loci and biological pathways for improving climate-resilient crop performance.
This study demonstrates that β-arrestin1 (ARRB1) inhibits colorectal cancer cell proliferation, migration, and invasion while promoting ferroptosis by facilitating p53 nuclear translocation to suppress the SLC7A11/GPX4 axis.
This study demonstrates that *Cucurbita maxima* leaf extract exhibits concentration-dependent α-amylase inhibitory activity and identifies Stigmasterol (CMP88) and Desmosterol (CMP91) as promising dual-target candidates for diabetes and androgen receptor-dependent prostate cancer through integrated *in vitro* assays and *in silico* molecular docking and dynamics simulations.
This systematic review of 50 years of research in Nepal reveals a significant bias toward large, charismatic felids over small cats, with studies increasingly concentrated in protected areas and focused on big cats, thereby failing to address the conservation needs of the majority of the country's 13 felid species.
This paper presents the DISCOVERY-AGENT framework, which integrates JUMP Cell Painting profiles with human-governed multi-agent AI to generate and critique biological hypotheses, demonstrating the feasibility of auditable evidence processing while highlighting current limitations in achieving validated autonomous discovery and significant mechanistic findings.
This study reveals that the ESCRT-II subunit VPS25 controls skeletal fate commitment in mice and humans by mediating the lysosomal degradation of IGF1R, where its loss leads to receptor accumulation, a shift toward chondrogenesis over osteogenesis, and craniofacial abnormalities that can be rescued by IGF1R inhibition.
This paper proposes that to maximize cumulative cooperation within a limited budget, policymakers should adopt a "minority-control" strategy—rewarding minority cooperators or punishing minority defectors—to efficiently drive the population toward a stable cooperative state before allowing natural evolution to sustain it.
By analyzing age-varying contributions of neural modules to emotion generation and regulation, this study reveals a dynamic, non-linear reorganization of emotional brain architecture across childhood and adolescence, highlighting distinct developmental trajectories that underscore the need for stage-matched interventions.
This study demonstrates that NSD2 deficiency in cochlear hair cells disrupts the epigenetic landscape by reducing H3K36me2 levels, leading to aberrant extracellular matrix accumulation and severe hearing impairment, which can be mitigated through ECM intervention.