🧬 biology

GC-MS Based Phytochemical Profiling and Integrated In vitro and In silico Evaluation of Cucurbita maxima Leaf Extract Against Diabetes and Androgen Receptor Dependent Prostate Cancer

This study demonstrates that *Cucurbita maxima* leaf extract exhibits concentration-dependent α-amylase inhibitory activity and identifies Stigmasterol (CMP88) and Desmosterol (CMP91) as promising dual-target candidates for diabetes and androgen receptor-dependent prostate cancer through integrated *in vitro* assays and *in silico* molecular docking and dynamics simulations.

Original authors: Sozoni Khatun, Md. Jubel Hussein, Md Reduanul Haque Kavey, Md Jannatul Islam Polash, Md Anisur Rahman, Tasfia Saffat, Israt Jahan, Talha Jobayer Rifat, Mohammad Ali, Md. Maruf Hossen, Md. Abdullah Al

Published 2026-11-02

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CC BY 4.0

Original authors: Sozoni Khatun, Md. Jubel Hussein, Md Reduanul Haque Kavey, Md Jannatul Islam Polash, Md Anisur Rahman, Tasfia Saffat, Israt Jahan, Talha Jobayer Rifat, Mohammad Ali, Md. Maruf Hossen, Md. Abdullah Al Mashud, Arghya Prosun Sarkar

Original paper licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). ⚕️ This is an AI-generated explanation of a preprint that has not been peer-reviewed. It is not medical advice. Do not make health decisions based on this content. Read full disclaimer

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