4545 papers
The paper proposes a model where the transbilayer distribution of plasma membrane cholesterol is determined by the stoichiometric complexation of sterols with leaflet-specific phospholipids, predicting that the outer leaflet contains approximately two-thirds of the total cholesterol due to its higher cholesterol-to-phospholipid ratio.
This study introduces NDPAI, a neuroscience-inspired active inference framework that achieves competitive cross-subject wearable stress detection while providing superior probability calibration, interpretable decision-making, and adaptive computational efficiency through a dual-pathway architecture governed by Variational Free Energy routing.
This study analyzes a large multi-ethnic cohort to demonstrate that fractal motor activity regulation is significantly influenced by age, sex, physical activity levels, and race/ethnicity, with distinct patterns observed across different demographic groups that could enhance early Alzheimer's disease detection.
This study integrates transcriptomic data to identify mitochondrial dysfunction-associated genes in NAFLD, establishing a high-accuracy diagnostic model and uncovering novel therapeutic targets and immune microenvironment interactions.
This study demonstrates that Chuangyu Liquid promotes cutaneous wound healing by modulating an AKT1-centered regulatory network, a mechanism identified through network pharmacology, molecular docking, and validated by in vivo experiments showing increased Akt1 mRNA and AKT protein levels.
This study demonstrates that low TSG101 expression in clear cell renal cell carcinoma (ccRCC) is associated with malignant progression, poor prognosis, and an immunosuppressive landscape, suggesting its potential as a prognostic biomarker and therapeutic target.
This study identifies the highly conserved effector AvrYr28-01 as the target of the wheat immune receptor Yr28, explaining its broad-spectrum and potentially durable resistance against stripe rust despite the presence of unrecognized paralogous variants and age-dependent resistance suppression.
This paper proposes an optimal control strategy for an SEIVZ epidemic model incorporating Holling-IV incidence and information intervention, demonstrating that while the disease-free equilibrium is stable when with a backward bifurcation at , the combined application of information and treatment controls effectively mitigates disease spread while minimizing associated costs.
This study characterizes the spectral irradiance of various indoor lighting systems and backlit electronic devices, revealing that their blue-rich emissions can suppress human melatonin levels significantly within minutes to hours, thereby posing a substantial risk to circadian rhythms in typical professional and educational environments.
This systematic review of 29 studies involving adults aged 60 and older demonstrates that physical activity, particularly aerobic, resistance, and open-skill exercises, significantly enhances attentional functions and supports broader cognitive health in aging populations, offering a scalable strategy to mitigate cognitive decline.