4545 papers
SCPInt is a deep-learning framework that integrates heterogeneous single-cell proteomics datasets by explicitly disentangling biological and batch variations, thereby outperforming existing methods in preserving biological structure while providing quantitative insights into technical biases for scalable atlas construction.
This study demonstrates that repeated exposure to anthropogenic noise induces transient, time-dependent fluctuations in serum glucose levels in male Mongolian gerbils, while having less consistent effects on urea, cholesterol, and body mass, thereby highlighting the specific metabolic impact of acoustic pollution and the importance of monitoring post-exposure recovery dynamics.
This paper presents the Nine-Dimensional Weighted Computing Model (9-WCM), an AI-driven framework that integrates nine biological pillars and ESM-Fold protein structure analysis to generate a unified, topologically visualized biological age index for more accurate systemic aging assessment and health management.
Rifampicin treatment of in vitro grapevine cultures disrupts the dominance of *Mycobacterium* and restructures the endophytic community into a more even, heterogeneous assemblage without establishing a new dominant taxon, supporting a model of dominance relaxation and non-convergent reassembly.
This study reveals that in Central European fishponds, avian predators—particularly marsh harriers—are the primary drivers of duck nest predation, with risk levels significantly influenced by nest-specific factors like incubation stage and prior depredation, as well as varying spatial and temporal dynamics specific to predator groups.
This study demonstrates that Daikenchuto (DKT) improves colonic motility and modulates sex-specific gut microbiota in a mouse model of congenital hypoganglionosis, suggesting its potential therapeutic efficacy for this disorder.
This study demonstrates that FAM20A deficiency causes impaired alveolar bone formation in enamel–renal syndrome by disrupting Wnt signaling, a mechanism that can be partially rescued by pharmacological activation of the pathway.
Despite moderate-intensity exercise training, intermittent high-fructose corn syrup consumption in rats induced hippocampal neurodegeneration and orexin dysregulation alongside impaired glucose tolerance, with exercise offering only partial neuroprotection against these metabolic and cognitive deficits.
This study demonstrates that *Pseudomonas fluorescens* effectively biodegrades both PET sheets and PS blocks, with UV pretreatment significantly enhancing weight loss and structural deterioration through surface erosion and molecular cleavage, thereby offering a promising strategy for sustainable plastic waste valorization.
By analyzing ME/CFS gene expression signatures to identify metabolic pathways and matching them with potential therapeutics, this study demonstrates that pioglitazone, tideglusib, and MHY1485 can enhance mitochondrial metabolism in muscle cells, offering a novel framework for treating pathological fatigue.