4545 papers
This study demonstrates that the human LRRCC1 gene variant p.H69Q disrupts acentrosomal microtubule organizing center clustering, leading to defective meiotic spindle assembly, chromosome misalignment, and elevated egg aneuploidy.
This study demonstrates that endocytosis pathway activity varies across colorectal cancer molecular subtypes, correlates with key oncogenic signaling networks, and that low expression of the core adaptor AP2M1 specifically predicts improved survival in metastatic patients treated with anti-EGFR therapy, suggesting its potential as a biomarker for therapeutic stratification.
This paper establishes that evolutionary adaptation is fundamentally non-gradient due to an irreducible "evolutionary curl" arising from the non-commutativity of genotype-phenotype mapping and fitness gradients, a principle validated across 19 datasets and 180 populations with 100% support after resolving initial discrepancies.
This study demonstrates that desflurane exacerbates cognitive dysfunction and amyloid pathology in Alzheimer's disease mice by downregulating and altering the phosphorylation of hippocampal Syntaxin 1A, a deficit that can be reversed by STX1A overexpression, highlighting it as a potential therapeutic target for preventing anesthetic-induced neurocognitive disorders.
This study presents the first worldwide multicenter validation of the POLARIS preclinical polarizer, demonstrating its ability to rapidly and reproducibly produce hyperpolarized [1-¹³C]pyruvate across diverse biological models, imaging systems, and international research centers to enable standardized metabolic MRI for translational research.
This study demonstrates that high carbonate alkalinity under low salinity significantly reduces survival and induces metabolic depression, feeding compensation, and redox-energy remodeling in the Hong Kong oyster (*Crassostrea hongkongensis*), providing a theoretical basis for managing saline-alkaline aquaculture environments.
This study demonstrates that constructing modular mixed microbial cultures from substrate-specialized populations significantly enhances polyhydroxyalkanoate (PHA) accumulation and composition control from variable carboxylate feedstocks, including waste-derived acidogenic broths.
This study employs a multi-layer analytical strategy to reveal that stromal remodeling in steroid-associated osteonecrosis of the femoral head is a state-restricted, context-sensitive process where adipogenic rewiring is only partially coupled to a specific stress-adaptation program, rather than a uniform compartment-wide phenotype.
This study successfully developed a genetically marked *Phormia regina* blow fly strain expressing a fluorescent protein that retains normal development rates, thereby overcoming the technical barrier of tracking known-age larvae in the field to validate forensic age-estimation methods under realistic decomposition conditions.
This study characterizes the newly identified potato endophyte *Paenibacillus* sp. ST1, demonstrating how its physiological adaptations to the host environment enable stable colonization, improved plant growth, and enhanced viral tolerance through a mutualistic symbiosis.