4545 papers
This study demonstrates that the peach gene *PpSAT4* positively regulates adventitious root formation by modulating redox homeostasis, as evidenced by its conserved ability to enhance rooting traits and antioxidant enzyme activities in transgenic *Prunus salicina* and *Arabidopsis thaliana*.
This study characterizes *Lentilactobacillus buchneri* subsp. *silagei* strain AGA55 from Turkish shalgam through genome-resolved multi-omics, confirming its taxonomic identity, intrinsic safety, and significant probiotic potential evidenced by robust gastrointestinal survival, antioxidant activity, and selective cytotoxicity against colorectal cancer cells.
This study utilizes plasma proteomic profiling to demonstrate that the molecular pathways driving Alzheimer's disease and cognitive decline are distinct from those of normal aging, revealing unique signatures in immune, actin, and platelet-related proteins that offer new candidate biomarkers and therapeutic targets.
By integrating the largest single-cell and spatial atlas of brain malignancies, this study reveals that tumor evolution is driven by a balance of lineage-specific imprinting and convergent adaptation to a dominant mesenchymal state, which orchestrates distinct microenvironmental shifts and defines a specific proliferative niche that predicts severe clinical deterioration.
This study reveals that excess ammonium stress in *Nicotiana tabacum* triggers growth inhibition and metabolic shifts characterized by specific amino acid alterations and distinct transcriptional reprogramming, ultimately identifying six candidate transcription factors that regulate the plant's response to ammonium toxicity.
By integrating Mendelian randomization, single-cell, and bulk transcriptomic analyses, this study identifies LDHA and GRIK1 as key osteoarthritis biomarkers linked to the druggable genome and gut microbiome, with endothelial cells serving as pivotal mediators in the disease's underlying mechanisms.
This study demonstrates that individual differences in neuroticism shape the neural organization of conditioned threat learning by reducing the brain's ability to differentiate threat from safety signals, a pattern that specifically links neural threat representations to anxiety vulnerability within high-neuroticism individuals.
This study demonstrates that the membrane-associated protein PALMD is upregulated in ovarian cancer spheroids, where it promotes spheroid integrity and anoikis resistance by suppressing p53-mediated apoptosis, thereby facilitating peritoneal metastasis.
This computational study utilizes molecular docking to demonstrate that certain environmental pesticides, particularly DDT, exhibit significant binding affinity to the human Estrogen Receptor Alpha, suggesting their potential to act as endocrine disruptors by competing with natural hormones.
This pilot study found that while a 12-week exercise rehabilitation program significantly improved functional and physiological parameters in cancer survivors, circulating miRNAs (with the exception of miR-126) showed limited responsiveness to the intervention and only modest associations with these physiological adaptations, suggesting a need for larger controlled studies to validate their utility as biomarkers.