4545 papers
This study demonstrates that adult mice lacking the ability to form new compact myelin sheaths or provide metabolic support via Mct1 retain intact motor and fear learning and memory, indicating that these cognitive processes rely on non-canonical properties of pre-myelinating oligodendrocytes rather than the canonical functions of myelin in speeding neural conduction.
This study demonstrates that oxidized phosphatidylcholines, generated by iron-induced lipid peroxidation in multiple sclerosis grey matter, trigger neuronal necroptosis and neurodegeneration, a process that can be ameliorated by inhibiting necroptosis.
This study utilizes c-Fos immunohistochemistry to demonstrate that while the lateral hypothalamus is activated by both sensing and eating a high-fat diet, the paraventricular nucleus and basolateral amygdala respond specifically to sensory exposure, whereas the nucleus accumbens, ventral tegmental area, and central amygdala are activated only upon consumption.
This study demonstrates that *Staphylococcus aureus* cells released from early-stage biofilms exhibit significantly enhanced adhesion forces and rupture lengths on various medical substrates compared to planktonic or late-stage biofilm-released cells, suggesting their critical role in initiating new implant-associated infections under flow conditions.
This study integrates transcriptomic and biochemical profiling to elucidate the regulatory networks governing key quality traits in *Camellia sinensis* 'Emei Wenchun' and establishes a high-resolution DNA fingerprinting framework using 150 SNP markers to accurately verify parentage and protect elite breeding lines.
This study reveals that granulosa cell development and BMP15 expression are key determinants of laying performance, while oviduct magnum morphology and ZDHHC2 expression significantly influence egg shape traits in Huaixiang chickens.
This study reveals that STING functions as a novel transmembrane channel in the endoplasmic reticulum that recruits Aster-escorted cholesterol from the plasma membrane to maintain cholesterol homeostasis, a mechanism whose disruption leads to altered cholesterol distribution and reduced systemic corticosterone levels.
This study presents the first single-cell RNA sequencing analysis of feline peripheral blood immune cells exposed to *Toxoplasma gondii*, revealing that while lymphocytes dominate the cellular landscape, myeloid cells—particularly monocytes and neutrophils—undergo the most significant transcriptional remodeling and engage in critical IL-1 and CSF2-mediated communication during infection.
This study demonstrates that sex-reversed XX male rainbow trout exhibit superior reproductive traits and a sperm biochemical profile enriched in long-chain polyunsaturated fatty acids compared to normal XY males, highlighting significant genotype-dependent variations in reproductive physiology and sperm composition.
This study reveals that *Lycium intricatum* in Sicilian coastal dunes hosts diverse fungal communities dominated by Ascomycota and arbuscular mycorrhizal fungi, confirming its mycotrophic nature and highlighting its potential as a key species for dune stabilization and habitat conservation.