🧬 biology

Associations of mood, perceived stress, cognitive dietary restraint and the menstrual cycle in healthy New Zealand females: A prospective cohort study

This prospective cohort study of 97 healthy New Zealand females found no significant associations between subclinical ovulatory disturbances, menstrual cycle phases, and levels of perceived stress, cognitive dietary restraint, or mood.

Caitlin McKenzie, Karen Mumme, Robyn Lawrence, Beatrix Jones, Stacy Sims, Rebecca Paul, Nuria Romero-Parra, Kathryn Beck (…)2026-07-03
🧬 biology

Proteomic identification of secreted protein candidates mediating anti-colorectal cancer activity in a human-derived non-enterotoxigenic Bacteroides fragilis

This study employs activity-guided fractionation and proteomic analysis to identify 41 secreted proteins from a non-enterotoxigenic *Bacteroides fragilis* strain that synergistically inhibit colorectal cancer cell proliferation, offering new insights into microbiota-derived anti-cancer mechanisms.

Yiting Peng, Lian Huang, Mingzhu Chen, Hao Yang, Yu Gan, Ningyan Wang, Maijian Wang, Zhongmin Yang, Jida Li2026-07-03
🧬 biology

Seamless molecular cloning through homology-annealing extension mediated fusion PCR enables efficient assembly of multiple DNA fragments

This paper introduces HAEMF-PCR, a streamlined, cost-effective method for the seamless assembly of multiple DNA fragments using only a high-fidelity polymerase and terminal overlaps, which demonstrates superior cloning efficiency and scalability compared to traditional multi-enzyme homology assembly techniques.

Xianyong Ma, Jie Tang, Yasin Oduck, Charles X. Ma2026-07-03
🧬 biology

MyD88 sustains a metastasis-competent cell state by promoting integrin-mediated adhesion in melanoma

This study identifies the adaptor protein MyD88 as a critical, environmentally responsive regulator that sustains melanoma metastatic competence by promoting integrin-mediated adhesion and plasticity, thereby enabling tumor cells to invade, intravasate, and colonize distant organs without affecting primary tumor growth.

Federica Marocchi, Matteo Lafranconi, Federico Lazzarini, Fiorenza Lotti, Erika Mileti, Luca Mazzarella, Laura Furia, An (…)2026-07-03
🧬 biology

Aberrant Autophagy–Senescence Axis Drives Spontaneous Abortion through HSPA6/FOXO1-Mediated Decidual Stromal Dysfunction

This study reveals that elevated branched-chain amino acids impair autophagic flux in decidual stromal cells, triggering excessive senescence via the HSPA6/FOXO1 signaling pathway and leading to spontaneous abortion, a process that can be mitigated by restoring autophagy.

Hai-Xia Tan, Shao-Liang Yang, Jia-Wei Shi, Meng-Ying Li, Si-Man Chen, Xiao-Yan Cao, Wen-Jie Zhou, Ming-Qing Li, Feng Xie2026-07-03
🧬 biology

A Probiotic-Derived Oxydifficidin from Bacillus subtilis Y4 Combines Direct Antibacterial Activity and Immunomodulatory Effects Against Multidrug-Resistant Acinetobacter baumannii Infection

This study identifies oxydifficidin, a probiotic-derived metabolite from *Bacillus subtilis* Y4, as a promising therapeutic agent that combats multidrug-resistant *Acinetobacter baumannii* infections through direct membrane-disrupting antibacterial activity and immunomodulatory effects that reduce lung inflammation and bacterial burden in immunosuppressed mice.

Xinyuan Li, Haowen Yan, Jinyu Mou, JinYang Gu, Lili Guan, Jingrui Chen, Lingcong Kong, Hongxia Ma, Haipeng Zhang2026-07-03
🧬 biology

AlGaN/GaN heterojunction field effect transistor structure integrated photoelectrode probe with optical artifact suppression function

This paper presents an integrated photoelectrode probe utilizing AlGaN/GaN heterojunction field-effect transistors with a differential recording architecture to simultaneously stimulate neurons and acquire high-quality electrophysiological signals while suppressing optical artifacts by 90%.

Xin Cao, Yanyuan Ding, Xi'en Yang, Wenbo Zhao, Xiaodong Li, Ye Wen, Yang Li, Xilei Huang, Zeyi Li, Jiefeng Weng, Baijun (…)2026-07-03
🧬 biology

Evaluation of octocoral-specific primers for environmental DNA (eDNA) metabarcoding of the coral reefs of Okinawa, Japan

This study evaluates three primer sets for octocoral eDNA metabarcoding in Okinawa and identifies a new mtMutS primer set as the most effective tool for detecting octocoral biodiversity, outperforming existing markers in both mock communities and field samples.

Agus A. Hakim, Fabian Gösser, Jue Alef A. Lalas, Emmeline A. Jamodiong, Anže Abram, Ulla von Ammon, Guillermo M. Castell (…)2026-07-03