4545 papers
This study demonstrates that overexpressing astrocytic LRP4 during the latent phase of pilocarpine-induced status epilepticus mitigates hippocampal sclerosis and seizure progression by shifting reactive astrocytes toward a vascular-supportive repair state and enhancing gliovascular communication.
This study demonstrates that mid-infrared spectroscopy combined with supervised machine learning can accurately determine the age class of the arboviral vector *Culex pipiens* with high resolution, offering a promising tool for assessing pathogen transmission risks and evaluating vector control strategies.
This study reveals that Bergmann glia serve as a local source of noradrenaline in the cerebellum, where calcium-dependent release via VMAT2 modulates synaptic integration in Purkinje neurons to drive adaptive motor behavior despite sparse traditional noradrenergic innervation.
This literature review synthesizes evidence demonstrating that early life stress and biological sex independently and interactively shape adolescent neurodevelopment and immune function through shared critical periods mediated by the HPA and gonadal axes.
This paper presents a comprehensive cross-kingdom phenotype dataset comprising over 7 million annotations for 35,856 animal, plant, and fungal species, generated through a web-search-enabled large language model pipeline to facilitate broad-scale comparative biology and conservation research.
This study presents a computational framework combining cross-gene mutation mapping and AI-driven pathogenicity prediction to identify and functionally validate the FGFR2 D650G variant as a novel actionable driver sensitive to FDA-approved inhibitors, offering a strategy to resolve the clinical ambiguity of variants of unknown significance in precision oncology.
This study demonstrates that dietary coconut milk mitigates D-galactose-induced aging and neurotoxicity in *Drosophila melanogaster* by modulating oxidative stress and neurotransmitter dysfunction, a mechanism supported by the high binding affinity of its bioactive component, oleic acid, to key enzymes like AChE and GST-2.
This study demonstrates that assuming constant population recruitment in environmentally transmissible disease models can erroneously predict stable equilibrium states, whereas incorporating exponential or logistic recruitment reveals critical Hopf bifurcations and sustained oscillations, highlighting the necessity of accurate recruitment specifications to avoid misleading public health predictions.
This study utilizes transcriptomic analysis to demonstrate that nasopharyngeal carcinoma progression is driven by a stage-specific hybrid metabolic phenotype, characterized by the coordinated up-regulation of six core genes (LDHA, GAPDH, CS, CYC, MRPL3, and TIMMDC1) that activate both glycolysis and oxidative phosphorylation during advanced regional disease.
Using a rat model of traumatic stress, this study reveals that while single prolonged stress generally decreases default mode network connectivity and disrupts its natural evolution, it paradoxically enhances specific connectivity patterns during extinction testing, particularly involving the anterior cingulate cortex and rostral retrosplenial cortex.