4545 papers
This study employs multi-omics profiling and random forest modeling to characterize how engineered bioprocess conditions influence human pluripotent stem cell states, revealing mesodermal fate biases and establishing a predictive framework for optimizing cell maintenance and differentiation in biomanufacturing.
This study reveals that despite their bright coloration, lynx spiders remain cryptic to hoverflies because they absorb UV light like their flower backgrounds, allowing detection only at very close ranges where insects perform evasive maneuvers.
This study utilizes comprehensive genome-based analyses, including ANI, dDDH, and phylogenomic data, to demonstrate that *Lentzea roselyniae* and *Lentzea terrae* are later heterotypic synonyms of *Lentzea atacamensis* and *Lentzea soli*, respectively, and proposes their formal reclassification.
This study demonstrates that children with ADHD exhibit slower callosal neural transfer times compared to typically developing peers, suggesting that the disorder involves not only behavioral dysregulation but also less efficient interhemispheric integration during rapid visuo-motor tasks.
This study demonstrates that 4-methylumbelliferone (4MU) exerts antitumor effects in AML U937 cells through a hyaluronic acid-independent mechanism involving a metabolic shift toward oxidative phosphorylation and the downregulation of the CD147/MMP-2 axis.
This paper presents a unified hierarchical face-scalp-cortex mapping framework that enables precise, MRI-free non-invasive neuromodulation targeting by establishing latent correlations between external facial features and internal brain structures, a capability validated through experiments on phantoms and insomnia patients using a markerless robotic neuronavigation system.
The paper introduces ISPAT-3D, a hierarchical Bayesian framework that leverages 3D multiplexed tissue imaging to model spatially varying, zone-specific cell-type interaction networks, revealing volumetric immune-tumor dynamics and angiogenic remodeling patterns that are undetectable in traditional 2D analyses.
The study demonstrates that Senoversus, a dual-factor combination of CHIR99021 and bFGF, effectively rejuvenates both cellular and organismal aging by reversing epigenetic states and restoring transcriptional homeostasis, thereby extending lifespan and improving physiological function in mice.
This study demonstrates that silencing the deubiquitinating enzyme OTUB1 inhibits HepG2 liver cancer cell proliferation by promoting pyroptosis and inducing M1 macrophage polarization, thereby disrupting the tumor microenvironment.
This transdiagnostic study of 339 young adults reveals that heightened anhedonia-apprehension is uniquely associated with both reduced reward-related neural activity in the orbitofrontal cortex and ventral striatum, and unexpectedly heightened threat-related neural activity during fear extinction, underscoring the value of linking specific brain systems to empirically derived symptom dimensions.