4545 papers
This study establishes a causal link between eosinophils and diabetic nephropathy using Mendelian randomization and identifies five key genes (IL7R, CD53, BPTF, FNBP4, and ANKRD36B) through integrated single-cell RNA sequencing analysis, offering potential targets for the diagnosis and treatment of the disease.
Researchers identified and characterized a novel PldB domain-containing esterase (PLR5) from a freshwater pond metagenome, which exhibits optimal activity on short-chain esters at 45°C and pH 8.0, along with significant solvent tolerance and a conserved catalytic triad, highlighting its potential for industrial biotransformation applications.
This study employs an integrated systems biology approach to identify distinct immune-related hub genes, specifically CXCL10, VCAM1, and CD40, as potential biomarkers and therapeutic targets for Epstein–Barr virus-positive intestinal-type gastric cancer.
This study establishes a human hematopoietic stem cell model of Congenital Dyserythropoietic Anemia Type II (CDAII) by knocking out the SEC23B gene, which successfully recapitulates the disease's characteristic erythroid differentiation defects, cell-cycle decoupling, and multinucleation, thereby providing a valuable platform for investigating pathophysiology and developing new therapies.
This study reveals the heterogeneous co-circulation of multiple DENV-1 and DENV-2 genotypes during Vietnam's 2023 outbreak, highlighting the critical need for whole-genome surveillance to monitor dengue diversity beyond simple serotype classification.
This study demonstrates that the South American grasshopper *Paramastax nigra* employs a deimatic display of vibrating white hindwings as a secondary defense mechanism, which is triggered at greater distances when its primary camouflage fails on unmatched backgrounds.
This study reveals that while the invasive species *Ageratum conyzoides* and *Chromolaena odorata* achieve reproductive success through pollinator-independent strategies, *Mikania micrantha* relies more heavily on pollinator-mediated reproduction alongside vegetative propagation for its invasion success in the Eastern Himalaya.
This study demonstrates that cell surface desialylation attenuates EGFR-mediated signaling by disrupting specific N-glycan-phosphorylation interactions and distinctively suppressing MAPK and cytoskeletal pathways, thereby revealing glycan remodeling as a potent strategy to sensitize RTK-driven malignancies to therapy.
Despite an intensive 18-month field study in southeastern Gabon involving over 12,000 trap-nights, researchers failed to capture or detect *Plasmodium* infections in the thicket rat *Grammomys poensis*, suggesting that local transmission may be absent or severely constrained compared to historical reports and highlighting the urgent need for contemporary field isolates to improve rodent malaria research models.
This study utilizes deep mutational profiling of normal lung tissue to demonstrate that aging, smoking, and anti-cancer therapies drive context-dependent clonal selection, revealing distinct mutational landscapes and convergent evolution that differ significantly from those observed in lung cancers.