4545 papers
This study on wild Western Australian magpies demonstrates that problem-solving performance requires testing beyond chance levels to be meaningful and reveals no correlation between an individual's ability to solve novel puzzles and their associative learning scores, challenging the assumed link between these two cognitive traits.
This paper introduces a generative causal representation learning method that successfully separates stimulation artifacts from therapeutic signals in Parkinson's disease deep brain stimulation, enabling the identification of a stimulation-orthogonal neural biomarker that accurately tracks motor improvement without supervision of clinical outcomes.
This study presents the first national cohort analysis of 648 individuals in the Dominican Republic, characterizing a distinct spectrum of 15 pathogenic BRCA1/BRCA2 variants to improve genomic representation, variant interpretation, and precision medicine for Caribbean populations.
This study utilizes molecular dynamics simulations to demonstrate that gain- and loss-of-function mutations in *Euglena gracilis* phytoene synthase alter carotenoid production by inducing distinct conformational remodeling of the enzyme's energy landscape, residue mobility, and active-site architecture.
This study systematically identifies and characterizes the eight KNOX genes in *Eucommia ulmoides*, revealing their phylogenetic classification, tissue-specific expression patterns, and distinct regulatory roles in development and responses to various phytohormones and abiotic stresses.
This study employs a comprehensive computational workflow to characterize WWV93726.1, a conserved hypothetical protein from the jumbo phage vB_Pae3705-KEN49, identifying it as a non-canonical, bimodular DNA-binding regulatory protein that likely governs the transition from phage transcription to assembly through an electrostatically driven interaction with viral promoter sequences.
This study expands the clinical and molecular understanding of Lessel-Kreienkamp syndrome by characterizing 45 new individuals with AGO2 variants, revealing a multisystemic neurodevelopmental disorder driven by diverse structural perturbations that disrupt specific AGO2 functions—including miRNA binding, P-body assembly, and phosphorylation-dependent turnover—thereby linking distinct molecular mechanisms to phenotypic variability.
The paper introduces GeneRhythm, a novel framework that reformulates single-cell gene expression analysis in the time-frequency domain to uncover rhythmic regulatory programs and disease-relevant dynamics that are invisible to conventional time-domain approaches.
This study characterizes the gut microbiota of three insectivorous bat species in Japan, revealing that both host species and sampling location significantly shape community composition while identifying the first detection of *Chlamydophila psittaci* alongside other pathogens like *Bacillus cereus* and Shiga toxin-producing *Escherichia coli*, thereby highlighting the importance of wildlife microbiome surveillance for One Health.
This metagenomic study reveals that while small-sized (0.1–0.45 µm) and large-sized (>0.45 µm) river bacteria exhibit distinct antibiotic resistance gene compositions and host communities, they ultimately pose comparable antimicrobial resistance risks, highlighting the significant and previously overlooked role of small-sized bacteria in environmental resistomes.