🧬 biology

Performance of a fine-scale positioning acoustic telemetry array in a deep freshwater ecosystem

This study evaluates a fine-scale positioning acoustic telemetry array in a deep freshwater ecosystem, finding that while detection efficiency varies with tag power, receiver spacing, and temperature, the system remains effective for accurate animal positioning with receivers spaced 400–800 meters apart.

Benjamin L. Hlina, Aaron T. Fisk, Dale M. Webber, Neil Rooney, Timothy B. Johnson2026-07-02
🧬 biology

Early-life stress shapes tissue-specific gut-brain metabolomic and microbial profiles in laying hens

This study demonstrates that early-life stress in laying hens induces persistent, tissue-specific metabolic and microbial reorganization along the gut–brain axis in adulthood, characterized by localized lipid and redox alterations in the ileum and brain while systemic plasma profiles remain largely unaffected.

Annemarie J.W. Mens, Ingrid C. de Jong, Soumya K. Kar, René P. Kwakkel, Edoardo Zaccaria2026-07-02
🧬 biology

Comparative Ion Channel Transcriptomes of NK1R and Somatostatin Neurons in the preBötzinger Complex of the Ventrolateral Medulla

This study utilizes single-nucleus RNA sequencing to characterize the distinct ion channel transcriptomes of Tacr1+ and Sst+ neurons in the preBötzinger Complex, revealing that Tacr1+ neurons possess a unique molecular signature involving coordinated upregulation of TRPC5, NALCN, and specific neuromodulatory receptors that likely underpin their critical role in generating respiratory rhythms.

Hemalatha Bhagavan, Aguan D. Wei, Luiz M. Oliveira, Jan-Marino Ramirez2026-07-02
🧬 biology

Host induced microRNA hsa-miR-643 promotes Mycobacterium tuberculosis survival inside macrophages by downregulating Gins2

This study demonstrates that the host microRNA hsa-miR-643 promotes *Mycobacterium tuberculosis* survival within macrophages by directly targeting and downregulating Gins2, thereby inhibiting apoptosis and suggesting hsa-miR-643 as a potential therapeutic target for tuberculosis.

Garima Kumari, Ruchi Verma, Mohd Mustkim Ansari, Rajendra Kumar Dhuriya, Gunjan Tripathi, Bhupendra N Singh2026-07-02
🧬 biology

Genomics and transcriptomics of nervous system from Rhodnius prolixus, and its modulation after a blood meal in an immature stage

This study utilizes improved genomic data and transcriptomic analysis to characterize the nervous system of the Chagas disease vector *Rhodnius prolixus*, revealing that blood feeding in fifth instar nymphs triggers a widespread downregulation of genes involved in physiological processes, suggesting a shift from a starved, responsive state to a post-feeding, less responsive condition.

Natalia Capriotti, Lucila Traverso, Jose Manuel Latorre Estivalis, Ivana Sierra, Juan P. Ianowski, Sheila Ons2026-07-02
🧬 biology

Molecular dynamics simulation of the effect of initial temperature and initial pressure on thermal behavior and cavitation dynamics in tumor tissue

This study employs molecular dynamics simulations to demonstrate that while initial temperature and pressure variations (280–310 K and 0–2 bar, respectively) do not alter the saturation or equilibrium temperatures of a tumor tissue model, they significantly influence structural expansion and thermal conductivity through non-monotonic trends, with optimal thermal and structural properties observed at 1 bar due to a balance between interatomic spacing and atomic mobility.

Mohsen shafiee, Ghanbarali Sheikhzadeh2026-07-02
🧬 biology

Natural Phenolic Acids Modulate Memory and Anxiolytic Behavior in Adult Zebrafish (Danio Rerio): Serotonergic Involvement, Oxidation-Dependent Activity, Quantum Calculations, and Molecular Docking Highlight Sinapic acid

This study demonstrates that natural phenolic acids, particularly sinapic acid, exert dose-dependent anxiolytic and memory-preserving effects in adult zebrafish through serotonergic mechanisms and oxidation-dependent activity, as confirmed by behavioral assays, molecular docking, and quantum calculations.

Thaís Rocha Cavalcante, Jéssica Bezerra Maciel, Amanda Maria Barros Alves, Joilna Alves Silva, Jacilene Silva, Tainá Sou (…)2026-07-02
🧬 biology

The Impact of Obesity on Appetite Regulation During Nutritional Ketosis

This study demonstrates that while a ketogenic diet improves metabolic parameters and reduces snack-directed behavior in diet-induced obese mice by remodeling hypothalamic melanocortin signaling, obesity-associated neuroendocrine alterations persist despite these beneficial changes.

Mateusz Grabowski, Konstancja Grabowska, Marta Nowacka-Chmielewska, Andrzej Małecki, Halina Jędrzejowska-Szypułka, Jaros (…)2026-07-02