4545 papers
The paper introduces CellPolariS, a novel image analysis framework that overcomes existing limitations in throughput and spatial resolution to accurately quantify the dynamic subcellular polarity of diverse cell types across tissues, revealing critical insights into polarity changes during hematopoietic differentiation and its rapid temporal dynamics in living cells.
This prospective study of breast cancer patients utilized whole-exome sequencing to identify four rare variants in candidate genes (CYP2C8, SLCO1B1, ABCB1, and EPHA8) associated with moderate-to-severe chemotherapy-induced peripheral neuropathy, highlighting the potential role of low-frequency genetic variants in ADME and neurological pathways as predictors of treatment toxicity.
This study demonstrates that analyzing smartphone IMU data from a 30-second chair stand test, rather than just counting repetitions, enables the accurate prediction of key body composition and strength biomarkers such as grip strength, body fat percentage, and lean mass.
This study characterizes Salmonella isolates across the broiler production chain in Fujian, China, revealing that the dominant ST11 clone of Salmonella Enteritidis is widely distributed with high virulence conservation in breeding stages, while processing plants exhibit significantly elevated antimicrobial resistance rates.
This study systematically characterizes the RBOH gene family across 22 Brassicaceae species, revealing that whole genome duplication is the primary driver of its expansion and providing insights into the stress-responsive regulatory mechanisms of BnRBOHs to support the molecular breeding of stress-tolerant rapeseed.
This study documents the first record of the North American beetle *Hesperobaenus rufipes* in South America, specifically in soybean and corn fields in Goiás, Brazil, marking a significant expansion of its known geographical range.
This study characterizes the African clade-3 bat Sarbecovirus PRD0038, demonstrating its inability to infect human cells via ACE2, its susceptibility to existing antivirals and some antibodies, and its potential to utilize intermediate hosts, thereby defining the functional and immunological constraints that limit its emergence while highlighting available therapeutic countermeasures.
Using airborne lidar and field data across the United States and Puerto Rico, this study reveals that while forest structural diversity is a significant driver of taxonomic diversity for birds, mammals, and beetles, these relationships are taxon-specific and vary in strength and direction, unlike the weak association observed for plants.
This genome-wide analysis of six millet and related C₄ grass species reveals that synonymous codon usage bias actively shapes CpG dinucleotide architecture in coding sequences, suggesting that codon choice and arrangement preconfigure the structural substrate for gene body methylation and extend the functional role of codon bias beyond translational efficiency to include an epigenetic dimension.
This study reveals that type 2 diabetes and cardiovascular magnetic resonance-derived cardiac remodeling share significant genetic architecture, identifying 156 shared loci and prioritizing 18 candidate genes, including six core immune-regulated genes, that may drive diabetes-related cardiac structural alterations.