4545 papers
This study utilizes shotgun metagenomic profiling to demonstrate that dysbiotic shifts characterized by an increased ratio of *Streptococcus* and *Veillonella*-associated species (sCAG5 and sCAG4) to butyrate-producing bacteria (sCAG10) serve as a novel intestinal microbial indicator of hepatitis E disease severity.
This study identifies optimal methyl jasmonate induction conditions and utilizes RNA-seq combined with WGCNA to pinpoint key genes, including the significantly upregulated UGT88F3 and 15 other candidates, involved in the biosynthesis of the medicinal compound kinsenoside in both diploid and tetraploid *Anoectochilus roxburghii*.
This study demonstrates that low GROα/CXCL1 expression predicts poor survival and promotes tumor progression in triple-negative breast cancer, revealing a context-dependent tumor-suppressive role that warrants further investigation as a prognostic biomarker and therapeutic target.
This study presents the first comprehensive assembly and characterization of the *Camellia pitardii* mitochondrial genome, revealing its structural features, gene content, and evolutionary dynamics while highlighting topological incongruence between mitochondrial and chloroplast phylogenies to provide a foundational resource for future comparative genomics and germplasm utilization in the genus *Camellia*.
This study comprehensively identifies and characterizes 283 CYP450 genes in *Coptis chinensis*, revealing their uneven chromosomal distribution, tissue-specific expression, and significant upregulation under low-light and long-photoperiod conditions, which suggests a regulatory role in alkaloid accumulation mediated by light-responsive and MeJA elements.
By integrating public genetic and expression resources, this study demonstrates that Alzheimer's disease risk and β-amyloid burden represent distinct biological processes, identifying BIN1 as a broad risk anchor while showing that the previously implicated ZNF227 signal is primarily driven by APOE-region variants rather than independent amyloid pathology.
This study integrates BSA-Seq, RNA-Seq, and WGCNA analyses to elucidate the molecular mechanisms of maize resistance to *Fusarium graminearum*, identifying eight resistance-associated loci and six high-confidence candidate genes involved in oxidative stress, hormone signaling, and cell wall modification that distinguish the resistant inbred line K0743 from the susceptible K0742.
This study reveals that *Toxoplasma gondii* infection impairs maternal-fetal tolerance and causes adverse pregnancy outcomes by suppressing the pSTAT3/KLF6 axis, which downregulates LILRB4 on decidual macrophages and disrupts the IDO/iNOS immunoregulatory balance.
This proof-of-concept machine learning study demonstrates that simulated circulating cell-free DNA methylation and miRNA profiles can achieve high accuracy in distinguishing cancer-associated from healthy molecular states, while explicitly emphasizing that these computational results do not validate operational forensic applications and require extensive wet-lab validation and ethical safeguards before any investigative use.
This study identifies DDI2 as a key regulator of autophagy impairment in diabetic peripheral neuropathy through proteomic and transcriptomic analyses of db/db mouse sciatic nerves and RSC96 cells, proposing a comprehensive therapeutic strategy involving the natural compounds fraxetin and cytisine, as well as ATF3 overexpression, to restore autophagic flux and reverse metabolic dysregulation.