1498 papers
This study identifies the miR-195/EIF4E axis as a critical mechanism linking peripheral immune dysfunction to central white matter pathology in schizophrenia by regulating BDNF translation and exerting context-dependent immunomodulatory effects.
This study reveals that WRNIP1 preserves genome stability by interacting with and stabilizing the G-quadruplex helicase FANCJ through an ATM-dependent signaling axis, thereby facilitating the resolution of R-loop-associated G-quadruplex structures.
By integrating multi-modal approaches to map the cellular diversity, connectivity, and developmental trajectory of the vestibular periphery, this study establishes a hierarchical molecular scaffold that links embryonic origin to specific neuronal subtypes and their functional roles in balance and spatial orientation.
This multi-cohort study demonstrates that ultra-processed food consumption is associated with a reproducible and modifiable DNA methylation signature across diverse study designs, implicating key genes involved in endothelial signaling, DNA damage response, neuronal function, and metabolic regulation.
The paper introduces CAPRA, a novel response-anchored model that predicts single-cell transcriptional responses to genetic perturbations by combining control states, gene embeddings, and learned corrections, thereby achieving superior accuracy and interpretability in both single- and double-gene tasks compared to existing methods.
This study presents the first complete assembly and comprehensive comparative analysis of the *Nephelium lappaceum* (rambutan) mitochondrial genome, revealing its structural features, RNA editing patterns, and evolutionary relationships within Sapindaceae to provide a foundational resource for future functional and phylogenetic research.
This study reveals that Deformed Wing Virus infection in honeybees redirects glucose carbon to the oxidative pentose phosphate pathway to generate NADPH, which fuels juvenile hormone biosynthesis and drives precocious behavioral maturation, thereby establishing a conserved metabolic–redox–endocrine axis linking stress-induced metabolic reprogramming to behavioral outcomes.
Through a large-scale in-silico screening of over 22,000 bacterial cryptochrome/photolyase proteins, researchers identified a thermophilic candidate, A0A6M1RS91, which possesses an expanded flavin–tryptophan electron-transfer network, making it a promising new target for investigating radical-pair photochemistry and magnetic-field sensitivity.
This study reveals that the Fas–FADD–caspase-8 axis acts as a critical, cancer cell-intrinsic determinant of susceptibility to cytotoxic lymphocyte-mediated killing through mechanisms that extend beyond the canonical executioner caspase-dependent apoptotic pathway.
This study reveals that the chromatin remodeler BPTF transcriptionally activates FAM155B, which in turn drives breast cancer progression and paclitaxel resistance by upregulating SREBP1-mediated fatty acid metabolic reprogramming.