3726 papers
This study demonstrates that dynamic, reversible N6-methyladenosine (m6A) RNA modifications serve as a rapid post-transcriptional switch regulating antimony resistance genes in *Leishmania infantum*, exhibiting a dose-dependent "epitranscriptomic memory" that correlates methylation changes with gene expression levels to drive drug resistance.
This study reveals that while group-level space–time interference effects are robust in children, the individual difference scores used to measure these effects are statistically unreliable, rendering previous claims about developmental changes or correlations with cognitive capacity uninterpretable.
Low-dose rapamycin alleviates age-related senescence in human facial dermal fibroblasts by inhibiting mTOR signaling and enhancing autophagy, with the most pronounced therapeutic effects observed in cells derived from women aged 40–49 years.
This study demonstrates that the assembly of water bug communities (Nepomorpha and Gerromorpha) in Cerrado freshwater habitats is driven by a complex interplay of environmental, landscape, and spatial factors, with the relative importance of these drivers varying significantly between lentic and lotic habitats and between the two taxonomic groups.
This study identifies a previously unrecognized population of medial slow myofibres in zebrafish, marked by Fhl2 expression and dependent on Hedgehog signaling, which exhibit unique molecular characteristics and demonstrate exceptional resilience and regenerative capacity in muscular dystrophy.
This study establishes *Acinetobacter baylyi* ADP1 as a versatile microbial platform capable of efficiently converting diverse lignin-derived aromatics into multiple flavonoids using a novel enzyme combination, enabling sustainable production directly from complex industrial lignin streams without the need for extensive genetic re-engineering.
This study demonstrates that while structural components of *Lactobacillus gasseri* and *Lacticaseibacillus rhamnosus* are sufficient to induce IL-10 secretion in THP-1 cells, live bacterial preparations elicit a significantly more robust and rapid transcriptional response, highlighting the critical role of viability in amplifying anti-inflammatory modulation.
This study investigated the differential effects of nucleus accumbens shell versus core lesions on body weight in healthy and activity-based anorexia female Wistar rats, finding distinct but statistically non-significant post-lesion weight trajectories that suggest a need for sham-controlled, histologically verified future research to clarify the subregions' roles in weight regulation.
Shetti-AI is a computational framework that integrates physicochemical properties, genetic distances, and generative adversarial networks to predict protein mutational landscapes and generate optimized motif-like variants, thereby accelerating functional assays and reducing experimental search spaces in synthetic biology and virology.
This study optimized the production and purified uricase from *Bacillus subtilis* and peroxidase from *Armoracia rusticana* using response surface methodology to develop a sensitive, cost-effective colorimetric assay for uric acid detection in human serum with high accuracy and low detection limits.