5841 papers
This study establishes a palmitoylation-based molecular framework for stratifying pancreatic cancer patients and identifies FNDC3B as a critical prognostic driver that promotes tumor progression and macrophage-mediated microenvironment remodeling through mTOR signaling.
This study demonstrates that HDAC1 overexpression in Luminal A breast cancer reduces chemosensitivity to multiple drugs by promoting cell survival and inhibiting apoptosis through the regulation of chromatin remodeling and key signaling pathways like p53/RB1 and NRF2, potentially involving interactions with YY1.
This study identifies a specific plasma miRNA signature in Indonesian colorectal cancer patients and validates miR-92a-3p as a promising diagnostic biomarker with an AUC of 0.83.
This study demonstrates that natural methylation epialleles (NAME) in the promoter of the *CaNGA1* gene modulate the brassinosteroid signaling pathway to regulate seed size and weight in chickpea, establishing a proof-of-concept for utilizing epigenetic diversity to improve legume breeding.
This study demonstrates that in continuous-flow pulsed electric field treatment of yeast, the repetition rate and residence time act as independent factors influencing cell viability beyond their combined pulse count, necessitating their separate specification for accurate modeling and process control.
This study proposes a genomic strategy for constructing "target collections" from lettuce genebank accessions that prioritize diversity in specific trait-associated regions, offering a complementary alternative to traditional core collections for more efficient allele mining and pre-breeding despite potential trade-offs in genome-wide representation and the overrepresentation of rare haplotypes.
This study of Alalay Lagoon in Bolivia demonstrates that while fecal indicator bacteria effectively confirm chronic fecal contamination and support sanitary assessments, their weak correlations with opportunistic pathogens indicate they are insufficient as standalone predictors of microbiological risk, necessitating complementary molecular and physicochemical monitoring.
Mendel is a novel DNA foundation model trained with a variant-centric objective that outperforms existing models like Evo 2 in predicting allelic events, effectively prioritizing regulatory variants and significantly improving gene expression prediction across human tissues.
Through an integrative analysis of 141,428 single-cell and nuclei profiles from 36 patients, researchers developed a robust 12-gene signature anchored by copy-number variations that effectively distinguishes early hepatocellular carcinoma from chronic liver injury, achieving high diagnostic accuracy and prognostic value across independent cohorts.
This study reveals that adipocyte-derived TGFBI suppresses obesity-related adipose browning by downregulating β3-adrenergic receptor expression via the Notch/HES1/C/EBPα signaling axis, a process mediated specifically by its EMI domain and RGD motif.