3726 papers
This study reveals that individuals with Prader-Willi syndrome exhibit a significant reduction in cholinergic neurons and altered glymphatic markers in the nucleus basalis of Meynert, suggesting that impaired cholinergic function contributes to the disorder's cognitive and behavioral symptoms and may be a target for therapeutic intervention.
This study demonstrates that a spatial density-based clustering (S-DBC) framework offers a robust alternative to traditional home range-based methods for detecting and characterizing animal forays and dispersal patterns, as evidenced by its ability to identify distinct movement components and provide more consistent cross-population comparisons in translocated desert and Rocky Mountain bighorn sheep.
This study utilizes thick undehydrated hippocampal cryosections to characterize the CNS extracellular space, revealing that over 25% of the tissue volume consists of a porous network of narrow openings and larger vascular-adjacent voids that facilitate CSF flow and cell motility.
This paper presents a validated semi-analytical framework for fitting Pospischil-type cortical neuron models to real data, which not only corrected a critical unit error through independent cross-validation but also demonstrated that a JIT-optimized implementation is significantly faster than numerical integration while successfully revealing distinct excitability differences between mouse and human cortical cells.
This study utilizes metagenomic binning and structural analysis of a cable-bacteria enrichment biofilm to recover novel bacterial lineages, including the first non-polar report of *Candidatus* Electryoneota, and challenges assumptions about electron transfer mechanisms by revealing that high-density multiheme cytochromes form discrete clusters rather than continuous conductive wires.
This study identifies Penicillin-resistant *Staphylococcus aureus* (PRSA) in sewage water and demonstrates that these isolates remain susceptible to protein synthesis inhibitor antibiotics, highlighting sewage as a significant reservoir for resistant bacteria and the need for resistance monitoring in non-clinical environments.
Although multi-omics integration and AI-driven drug prediction initially highlighted an IGF1R/PIK3CA/BET axis as a therapeutic target for triple-negative breast cancer, subsequent CRISPR dependency screening and clinical validation refuted these nodes, revealing WEE1 inhibition and Mitoxantrone combined with BET inhibitors as the superior, functionally validated therapeutic strategy.
This study proposes that allosteric modulation of β-Klotho represents a mechanistically plausible therapeutic strategy to restore FGF21 sensitivity and overcome receptor-level resistance in type 2 diabetes, particularly within adipose tissue, based on integrated structural, genetic, and network-level evidence.
The paper describes the 2026 reimplementation of dictyBase as a self-contained, static-data-driven platform that consolidates genomic information, the complete Dicty Stock Center catalog, and an author-in-the-loop curation pipeline to serve the *Dictyostelium discoideum* research community.
Using CRISPR-engineered human iPSC-derived microglia, this study reveals that the APOE4 allele drives neurodegeneration in Alzheimer's disease by inducing NF-κB-mediated inflammatory remodeling in microglia, which leads to the release of extracellular vesicles enriched with proteasomal components that disrupt neuronal proteostasis and exacerbate tau pathology.