1498 papers
This study reconstructs the evolution of hemagglutinin (HA) phenotypic traits across thousands of H5N1 viruses to demonstrate that standing phenotypic breadth, rather than simple stepwise mutations, enables the virus to rapidly diversify and adapt to new hosts like dairy cattle, offering a scalable framework for prioritizing cross-host variants.
This study reveals that the long isoform of the cold-inducible RNA-binding protein (CIRBP-L) suppresses breast cancer metastasis by directly binding to and enhancing the translation of DCLK1-L mRNA, which subsequently stabilizes microtubules through the inhibition of the GSK3β–HDAC6 axis.
This study demonstrates that extreme instability in species trees across the genome of sagebrush lizards, driven by widespread introgression and geographic barriers, challenges the feasibility of inferring a single evolutionary history and supports recognizing multiple distinct species within the *Sceloporus graciosus* complex.
This study demonstrates that the loss of dRP lyase activity in DNA polymerase beta impairs mitochondrial DNA integrity and electron transport chain function by disrupting the ROS-antioxidant axis, leading to metabolic dysregulation and increased oxidative stress.
The paper introduces DeepSec, a robust nanoparticle-based method that selectively depletes bovine serum albumin from cell culture media to overcome dynamic range limitations, thereby enabling deep, quantitative proteomic profiling of the secretome across diverse physiological and pathological models.
This study utilizes naturalistic fMRI and behavioral data to demonstrate that the neural representation of belief is a multidimensional geometry organized primarily by belief directionality and extremity, revealing that certainty increases toward both strong belief and strong disbelief.
This paper presents a reproducible, CPU-accessible machine-learning framework that employs multi-objective active learning to navigate the vast LNP formulation space, successfully identifying lipid compositions that maximize brain delivery while minimizing liver tropism, thereby overcoming a major barrier to CNS mRNA therapeutics.
This study demonstrates that tropical forest trees exhibit modest, species-specific plasticity in photosystem II heat tolerance during a non-stress seasonal warming period, revealing that while community-level acclimation occurs, certain species already operate near functional thermal limits regardless of their leaf habit or successional status.
This study identifies DACH1 as a novel candidate epigenetic regulator in cervical squamous cell carcinoma, demonstrating through network analysis and TCGA data that its expression is inversely associated with promoter methylation of the tumor-suppressor genes CADM1, ESR1, and SLIT2, independent of global tumor hypermethylation.
This study highlights that the invasive boxelder tree (*Acer negundo*) possesses persistent, photosynthetically active chlorenchyma on its branches that utilizes high salicylic acid levels and efficient non-photochemical quenching mechanisms to protect its photosynthetic apparatus from light stress while maintaining activity throughout the year.