3726 papers
This paper proposes a Bayesian multiclass feature selection method using the relative belief ratio to identify discriminative genes in high-dimensional cancer datasets, demonstrating competitive classification accuracy and improved interpretability across various cancer types compared to existing filter-based approaches.
This study demonstrates that an epigenetic index of adult cognitive function (Epigenetic-g) captures distinct genetic and environmental influences on children's cognitive and academic development that are not reflected by polygenic indices, showing plasticity in early childhood before stabilizing in adolescence.
This study presents the first systematic characterization of the 17 PEBP genes in yam (*Dioscorea rotundata*), revealing their evolutionary history, tissue-specific expression patterns, and potential roles in regulating flowering, tuber development, and stress responses.
This study presents the first genome-wide association analysis integrating maternal and child genetics in Fetal Alcohol Spectrum Disorders (FASD), identifying novel risk-modifying loci (including STX6, FOXD3, HTR1E, COP1, WWOX, and TMEM38B) that influence neurobehavioral, growth, and diagnostic outcomes through interactions with prenatal alcohol exposure.
This study presents a high-quality, gap-free, chromosome-level, and haplotype-resolved genome assembly of the commercially significant apple cultivar Cripps Pink (Pink Lady®), generated using PacBio HiFi and Omni-C Hi-C technologies to provide a comprehensive genomic resource for advancing apple breeding and genetic research.
This study integrates single-cell and spatial transcriptomics to identify KRT81-positive non-classical epithelial cells as a key malignant subpopulation in solid-type adenoid cystic carcinoma that drives tumor progression and immune evasion through the MESP1/MACC1 and MIF axes, respectively.
This study integrates bioinformatics and machine learning to identify four glucose metabolism-related crosstalk genes (MARCKS, MAP3K1, LTF, and ZMIZ1) as shared diagnostic biomarkers for osteoporosis and frozen shoulder, revealing their association with distinct immune microenvironments and potential therapeutic targets.
This study identifies a specific LINE-1 transposable element insertion upstream of the GPR52 gene as a key regulatory driver that facilitated the rapid evolution of canine tameness by upregulating GPR52 expression, thereby attenuating threat responses without causing widespread behavioral disruption.
By applying empirical dynamic modeling to long-term aquatic microbial data, this study reveals that communities maintain dynamic stability through an emergent mechanism called interaction balance control, where subdominant species experience net positive interactions and dominant species experience net negative interactions to buffer against abundance fluctuations.
This study identifies the minimal peptide CBM7 as a chemically defined probe that induces a novel flexible filament-like CARD assembly in inflammatory caspases, revealing shared structural mechanisms between peptide and LPS binding that drive caspase activation and inflammatory responses.