1498 papers
This study reveals that frequent recombination and insertion–deletion events across the Coronaviridae family have significantly shaped its genomic organization, diversification, and phylogeny, while simultaneously complicating efforts to forecast the emergence of novel pathogenic variants.
The paper introduces ATLAZ, a memory-deterministic geometric engine that utilizes Topological Data Analysis to bypass traditional bifurcating phylogenetic trees, enabling the precise detection of viral recombination, the confirmation of clonal descent, and the rapid identification of antiviral targets through topological metrics.
This two-step, two-sample Mendelian randomization study provides genetically supported evidence that specific gut microbiota, such as *Rhodanobacter*, causally increase breast cancer risk partially through the mediation of specific immune cell characteristics, notably CD25hi CD45RA+ CD4 non-Treg cells.
This paper proposes a structured framework for "virtual cell world models" (VCWMs) to address critical gaps between current capabilities and true world modeling by defining formal requirements, presenting empirical evidence of these shortcomings through three experiments, and outlining a staged roadmap with diagnostic capability ladders for developing multiscale, interactive cellular simulators.
This paper establishes that while the classical simulability of fermionic variational quantum algorithms is encoding-dependent and can be optimized via gauge transformations, their trainability is strictly encoding-invariant, implying that genuine quantum advantage must rely on encoding-independent resources like Lie algebra dimension and non-stabilizerness rather than encoding-specific metrics like Pauli weight.
This study documents the high diversity and endemism of Adjara's ephemeroid flora, identifies *Cyclamen adzharicum* as a key medicinal species, and reveals its leaves as a superior source of antioxidant-rich triterpenoid saponins compared to its tubers, thereby supporting conservation efforts and future pharmacological research.
This study demonstrates that apparent incompatibilities between archaeal extremophilic traits, such as halophily and methanogenesis, are primarily artifacts of lineage clustering and phylogenetic pseudoreplication rather than intrinsic biochemical constraints, as evidenced by the frequent co-occurrence of these adaptations in non-Halobacteria lineages when analyzed using phylogenetically corrected methods.
This study demonstrates that the mechanical pivots of G protein-coupled receptors (GPCRs), defined by tightest local atomic packing, are significantly closer to the membrane center than those of other polytopic membrane protein folds, indicating that this central positioning is a distinctive feature of the GPCR superfamily rather than a universal property of transmembrane bundles.
This study identifies *Nepl15* as a critical, sex-specific regulator of glycogen and lipid storage in *Drosophila* that functions by attenuating insulin signaling downstream of the receptor, thereby linking intracellular metabolic pathways to nutrient homeostasis independently of food intake.
This study demonstrates that plastid codon evolution in *Platycerium* is jointly shaped by broad phylogenetic history and fine-scale sequence constraints, specifically revealing conserved CpG and TpA depletion at codon boundaries across eighteen species.