q-bio papers | Gist.Science

AI-Driven miRNA Target Identification Combined with Nanocarrier-Based Therapy Enhances Amastigote Clearance in Canine Visceral Leishmaniasis: An Integrated In Silico and Ex Vivo Study

This study demonstrates that integrating AI-driven prioritization of host miRNAs with miltefosine-loaded PLGA nanoparticles significantly enhances the clearance of *Leishmania infantum* in primary canine macrophages by modulating immune responses, providing a proof-of-concept for this combined therapeutic approach against canine visceral leishmaniasis.

Athanasios Spyridonis, Menelaos Lefkaditis, Ioannis Pappas, Theodoros Lialiaris, Panagiotis Perakis2026-10-26

🧬 biology

Optimization of Community-Consideration Centrality for Breast Cancer Comorbidity Using Various Community Detection Algorithms

This study optimizes the Community-Consideration Centrality (CCC) method for breast cancer comorbidity networks by demonstrating that combining it with the Leiden community detection algorithm and an $\alpha$ parameter of 0.9 yields the most stable and effective identification of key comorbid diseases.

Gilbert Evan Tilung, Angga Aditya Permana2026-10-26

🧬 biology

The FAK signaling pathway regulates the migration ability of highly metastatic hepatocellular carcinoma cells

This study demonstrates that the FAK signaling pathway, identified through integrated bioinformatics and experimental validation, critically promotes the migration of highly metastatic hepatocellular carcinoma cells and represents a promising therapeutic target.

Bingyu Zhang, Jin Li, Yue Zhang, Jiayu Wang, Dui Qin2026-10-26

🧬 biology

Global trait patterns and the economics spectrum of wood-inhabiting fungi

By synthesizing global data on 7,454 wood-inhabiting fungal species, this study establishes the first global economics spectrum of these fungi, revealing how multidimensional trait trade-offs and non-linear environmental responses drive functional adaptation and projecting future trait reorganization under climate change to improve forest carbon-cycle modeling.

Biao Zhu, Shun Liu, Shengmin Zhang, Chenrui Ni, Mengguang Han, Changlin Xu, Haozhi Ma, Lidong Mo, Mari Jönsson, Claus Bä (…)2026-10-26

🧬 biology

Morphologic description and molecular characterization of Trichobilharzia species (Digenea: Schistosomatidae) infection in field-collected Radix auricularia (Linnaeus, 1758) in North of Iran

This study confirms that *Radix auricularia* snails in northern Iran serve as intermediate hosts for *Trichobilharzia franki* and *Trichobilharzia regenti*, identifying specific molecular haplotypes and highlighting the need to investigate migratory waterfowl's role in transmission while implementing preventive measures for local residents.

Armin Aligolzadeh Kenarsari, Mohammad Yakhchali, Keyhan Ashrafi Fashi, Meysam Sharifdini2026-10-26

🧬 biology

Effect of Dexamethasone and diclofenac in combination with ceftriaxone on the virulence activities of different Pseudomonas aeruginosa clinical isolates

This study demonstrates that while many *Pseudomonas aeruginosa* clinical isolates exhibit high multidrug and extensively drug resistance, the combination of diclofenac and dexamethasone with ceftriaxone reduces bacterial growth and downregulates virulence genes (algD, plch, toxA), with green silver nanoparticles showing the most potent inhibitory effect on both growth and virulence factor expression.

Mohamed Mohamed Adel El-Sokkary, Adham Mohamed Ramadan, Islam El-Said Ibrahim, Ahmed Alaa Hussein Azzam, Islam Fouad Abd (…)2026-10-26

🧬 biology

Haplotype-resolved T2T genome reveals an ancient hybrid ancestry and functional specialization in red-skinned longan (Dimocarpus longan)

This study presents the first telomere-to-telomere haplotype-resolved genome of red-skinned longan, revealing its origin as an ancient hybrid between two deeply divergent lineages and demonstrating how haplotype-specific functional specialization drives unique horticultural traits like red pigmentation and dwarfism.

Jiaming Zhang2026-10-26

🧬 biology

Comparative Evaluation of Calcium Hydroxide Nanoparticles and Calcium Hydroxide–Loaded Poly(lactic-co-glycolic acid) Nanoparticles on Cytocompatibility, Osteoblastic Differentiation, and Mineralization under Inflammatory Conditions

This study demonstrates that both calcium hydroxide nanoparticles and calcium hydroxide-loaded PLGA nanoparticles exhibit favorable cytocompatibility and significantly enhance osteogenic gene expression in primary human osteoblasts under inflammatory conditions, although neither formulation significantly improved mineralization compared to controls.

Kruekfar Kasorntumkittiwuit, Parinthron Rattanakijkamol, Pongrapee Laorodphun, Warat Leelapornpisid, Napatsorn Imerb2026-10-26

🧬 biology

The second extracellular loop gates Stachel-mediated activation of ADGRG6/GPR126

This study utilizes cryo-EM structures and functional assays to reveal that the second extracellular loop (ECL2) of the adhesion GPCR ADGRG6/GPR126 acts as a tunable intramolecular gate that sterically and allosterically controls Stachel-mediated activation and G-protein signaling.

Patrick Scheerer, Franziska Wiechert, Michal Szczepek, Gunnar Kleinau, Lisa Kupsch, Amal Hassan Ali, Monique Gallandi, A (…)2026-10-26

🧬 biology

CausalDiffChem: Causal Network Restoration for Therapeutic Prioritization and Repurposing Across Diseases

CausalDiffChem is a novel framework that leverages transcriptomic data and structural causal models to prioritize drug repurposing candidates by simulating interventions that restore disease-specific causal network structures, thereby distinguishing causal drivers from downstream effects across diverse conditions.

Francis Armah, Evans Abor, Pius Sam, Emmanuel Sarpong, George Ghartey-Kwansah2026-10-26

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