q-bio papers | Gist.Science

Bioactive Compounds in Persea americana var. Quintal Byproducts: Exploring Their Antioxidant Potential and Inhibitory Effects on LDL Oxidation, Lipid Peroxidation, and Nitric Oxide Production

This study demonstrates that ethanolic extracts and organic fractions from *Persea americana* var. Quintal by-products (peel and seed) are rich in bioactive compounds like procyanidins and quercetin, exhibiting significant antioxidant, anti-lipid peroxidation, and nitric oxide inhibitory activities without cytotoxicity, thereby highlighting their potential as natural therapeutic agents for oxidative stress-related diseases.

Maria Sol Peña Carrillo, Romário Divino Vilarinho Galvão, Ana Luiza Silva Borges, Vinícius Prado Bittar, Iasmin Aparecid (…)2026-09-09

🧬 biology

Investigation of Stress Granule-Associated Biomarkers (IGF1 and CDK2) and Their Regulatory Mechanisms in Alzheimer’s Disease: A Combined Transcriptomic, Bioinformatic and Experimental Study

This study integrates transcriptomic analysis, machine learning, and experimental validation to identify IGF1 and CDK2 as potential biomarkers for Alzheimer's disease, demonstrating strong diagnostic performance via a neural network model and elucidating their regulatory mechanisms through miRNA interactions and molecular docking, despite partial validation discrepancies in clinical samples.

Milisha Wusiyin, Xinxue Wei, Xiaobei Liu, Aersi Aheizan, Abuduxukuer Maituzi, Rong Huang2026-09-09

🧬 biology

Phage-originated peptidoglycan hydrolase from Gammaproteobacterium bacterium: Does the guest serve the host?

This paper characterizes GammaM15, a novel phage-derived peptidoglycan hydrolase from a marine Gammaproteobacterium that requires both zinc and calcium ions for proper folding and lytic activity, and discusses its potential role in the host bacterium's life cycle.

Galina V. Mikoulinskaia, Sergei V. Chernyshov, Bogdan S. Melnik, Dmitry A. Prokhorov, Vladimir N. Uversky2026-09-09

🧬 biology

Genome-wide Identification and Characterization of the 3- Dehydroquinate Dehydratase/Shikimate Dehydrogenase Gene Family in Rubus chingii Hu

This study systematically identified and characterized the four-member RcDHD/SDH gene family in *Rubus chingii*, revealing their structural features, tissue-specific expression patterns, and a strong correlation between their early fruit developmental expression and the accumulation of gallic and ellagic acids.

Xueli An, Yuezhen Li, Yating Gong, Nana Feng, Bowei He, Dongfeng Yang, Hongfa Li, Jianhong Chen, Zhuoni Hou, Zongsuo Lia (…)2026-09-09

🧬 biology

Digestion and Gut-Modulating Functions of Six Dietary Oils: A Multi-Omics- Based Investigation into Oxidative Stability, Gas Production Profiles, and Microbiota Shifts

This multi-omics study utilizes an in vitro digestion model to demonstrate that the oxidative stability, colonic gas production profiles, and gut microbiota shifts of six dietary oils are distinctively determined by their fatty acid composition, revealing that polyunsaturated oils like fish and ARA promote higher gas production and specific bacterial proliferation compared to the milder fermentation effects of olive and camellia oils.

Yating Wang, Shuya Chen, Jintian Chen, Xixian Lv, Yin Yin, Wenxuan Yan, Zepeng Chang, Minjie Gao, Shiwei Song, Zhitao Li (…)2026-09-09

🧬 biology

Exposure to tetrabromopyrrole for as little as one hour reliably induces settlement across Caribbean coral species

This study demonstrates that a brief, one-hour pretreatment with tetrabromopyrrole (TBP) reliably induces settlement across diverse Caribbean coral species, offering a practical and effective strategy to overcome challenges in sexually propagated coral restoration.

Jennifer M Sneed, Margaret W Miller, Hannah Ditzler, Lilyana Newman, Valerie J Paul2026-09-09

🧬 biology

Rational Design and Experimental Validation of a CCR7-Targeted Multi-Epitope Cytokine Fusion Protein for Cancer Immunotherapy

This study reports the rational design, structural validation, and experimental characterization of a novel CCR7-targeted multi-epitope cytokine fusion protein that successfully activates both innate and adaptive immune responses to inhibit breast cancer growth and enhance systemic immunity in preclinical models.

Mohsen Yazdani, Maria Beihaghi, Hasan Marashi, Samad Khaksar2026-09-09

🧬 biology

LXR is an epithelial transcriptional checkpoint that restrains mucosal type 2 immunity

This study identifies the oxysterol-sensing nuclear receptor LXR as an epithelial transcriptional checkpoint that restrains mucosal type 2 immunity by selectively limiting tuft cell maturation and the subsequent amplification of the tuft cell-ILC2 circuit, thereby controlling the activation threshold of protective responses against helminth infections.

Eduardo Villablanca, Xinxin Luo, Ning He, Qilin Zhu, Tilde Andersson, Mora Massaro, Jennifer Fransson, Rodrigo Morales (…)2026-09-09

🧬 biology

Multiplexed single cell transcriptomics optimizes mesodermal patterning and hemogenic endothelial output from murine embryonic stem cells

This study utilizes sci-Plex single-cell transcriptomics to optimize the generation of hemogenic endothelial cells from murine embryonic stem cells by revealing how the dose and temporal integration of Activin and BMP4 signaling pathways govern mesodermal patterning and cell fate decisions.

Barbara Varnum-Finney, Adam Heck, Sanjay Srivatsan, Stacey Dozono, Rachel Wellington, Alisa Chankhunthod, Cynthia Nourig (…)2026-09-09

🧬 biology

Excessive force-induced root resorption depends on macrophage YAP activation

This study reveals that excessive orthodontic force induces root resorption by activating the Hippo-YAP signaling pathway in macrophages, which drives odontoclast/osteoclast differentiation via SOCS3, suggesting that targeting macrophage YAP offers a promising therapeutic strategy to mitigate this condition.

Yan Liu, Liyuan Chen, Shuyue Zhu, Wei Wang, Zimo Zhao, Huajie Yu, Boyang Zhang, Shiying Zhang, Yuwei Liu, Zhuowen Gu, Da (…)2026-09-09

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