3726 papers
This study provides the first integrated analysis of DNA methylation in Machado-Joseph disease, revealing that while brain alterations are subtle, region-specific, and enriched for myelination pathways, peripheral blood methylation changes are limited, do not mirror brain findings, and are more pronounced in preclinical carriers.
This study establishes ovarian fibrosis as a quantifiable and targetable hallmark of human reproductive aging by integrating multimodal profiling to demonstrate that age-associated ovarian stiffness, driven by a fibroinflammatory stromal program, correlates with reduced fertility and serves as a robust non-invasive biomarker.
This study utilizes in silico comparative bioinformatics and homology modeling to identify and structurally characterize the independent genes ClAPRR2 and ClPSY1 as promising targets for developing a white-rinded, orange-fleshed watermelon variety that offers enhanced color contrast for consumers with red-green color vision deficiency.
This study demonstrates that eight weeks of moderate-intensity treadmill exercise ameliorates motor deficits and neurodegeneration in Parkinson's disease mice by upregulating miR-7, which subsequently inhibits Drp1-mediated mitochondrial fission and restores PINK1-dependent mitophagy and synaptic function.
This paper introduces radial drawdown (RD), a scale-explicit method that identifies movement boundaries in discretely sampled animal tracks by detecting the farthest point from a recursively updated origin followed by a retreat, demonstrating superior accuracy and biological relevance compared to existing approaches across various species and movement models.
This study assesses coral-algal interactions, benthic composition, and coral health at four shallow sites around Santa Cruz Island, Galápagos, revealing that turf algae dominance and direct contact are significantly associated with reduced coral pigmentation and poorer health, while crustose coralline algae contacts show no visible damage.
This study utilizes spatial and single-cell transcriptomics to identify a low-butrate-metabolizing malignant epithelial subgroup in colorectal cancer associated with poor prognosis and stromal crosstalk, revealing that butyrate suppresses tumor progression by inhibiting the HOXB8/AKT/mTOR axis.
This study provides a genome-wide characterization of the 41 pyruvate kinase genes in upland cotton, identifying GhPK5 as a key positive regulator of salt tolerance through its stress-responsive expression and functional validation via gene silencing.
This study demonstrates that serum extracellular vesicles from patients with active systemic lupus erythematosus exhibit elevated concentrations and distinct proteomic signatures enriched in inflammatory pathways, with specific overexpression of TNFRSF17 and complement C9 suggesting their potential as biomarkers for disease activity and response to emerging targeted therapies.
This study integrated bioinformatics, Mendelian randomization, and machine learning to identify and experimentally validate seven core genes as Parkinson's disease biomarkers while screening and simulating potential therapeutic compounds targeting these genes.