1498 papers
The paper introduces MicroSC, a family of tiny, high-performance single-cell foundation models (1.5M–7.7M parameters) that achieve near-parity with much larger 51M-parameter teachers like scGPT through efficient knowledge distillation, enabling fast, cost-effective deployment on commodity hardware while demonstrating that the practical utility of current single-cell models is highly compressible.
This paper introduces Differentiable Subset Binding (DSB), a scalable, gradient-based method that overcomes the combinatorial limitations of traditional Apriori-based subset binding to efficiently identify maximal co-occurring itemsets across heterogeneous data views, outperforming existing baselines in both synthetic benchmarks and real-world biological applications.
The paper introduces HAPLOCLUST, a size-constrained, population-level clustering method that groups individuals based on HLA genetic similarity to minimize false disease associations and maximize within-group homogeneity, offering a robust alternative to self-reported ethnic classifications for improving transplant matching and genetic studies.
GeoBridge is a novel framework that models cellular dynamics as geodesic trajectories within a learned Riemannian metric space to enable the reconstruction of continuous, noise-robust transcriptional programs and the controlled navigation between distinct cell states from sparse, unpaired single-cell RNA sequencing data.
This study demonstrates that noradrenergic modulation of object recognition memory via β2-adrenergic receptors in the perirhinal cortex facilitates memory formation in female mice through familiarity-based mechanisms, whereas males exhibit distinct, stimulus-dependent responses, highlighting critical sex differences in the neural basis of memory.
This study develops and validates novel empirical substitution models specifically for SARS-CoV-2 proteins, demonstrating that they yield more accurate phylogenetic inferences and biologically realistic evolutionary predictions compared to existing generalist models.
This study demonstrates that short, 10-second video clips of affiliative conspecific social interactions serve as robust alternative reinforcers capable of maintaining operant responding in rhesus monkeys, offering a viable non-ingestive method for behavioral research.
This study demonstrates that exosomes derived from CD271+ umbilical cord mesenchymal stem cells promote angiogenesis in endometriosis by delivering miR-124-3p, which directly targets and suppresses PGF to enhance endothelial cell migration and tube formation.
In a longitudinal study of Gambian children, *Prevotella stercorea* is shown to protect against acute respiratory infections through a species-autonomous, host-context-dependent pathway that operates independently of overall gut microbiome richness, with its protective effects and immune interactions varying significantly based on the child's nutritional status (WAZ).
This study establishes a systematic framework for analyzing A-to-I RNA editing in single-cell transcriptomes by benchmarking diverse methods across over 1.1 million cells, identifying BCFtools with strand annotation as the optimal pipeline, and demonstrating how these tools reveal cell-type-specific editing dynamics reshaped by disease contexts like Down syndrome and cancer.