5841 papers
This study demonstrates that the choice of single-cell reference can systematically distort, reverse, or inflate associations in bulk deconvolution due to unaccounted cell-state shifts and donor sampling noise, necessitating references that resolve dynamic states and statistical models that account for reference uncertainty to ensure accurate inference.
This study identifies a novel auditory epigenetic transduction mechanism wherein music listening activates a c-Fos–GATA2–SIRT6–SIRT3–Dicer axis to preserve microRNA processing and extend healthspan, a process quantitatively modeled as synergistically enhanced by aerobic exercise and dietary lycopene.
This study reveals that the widely distributed E. coli protein SoFIC orchestrates a dual-layer antiviral defense by physically reinforcing extracellular barriers like fimbriae and biofilms while intracellularly coordinating metabolic homeostasis and synergizing with endogenous immune systems to block phage proliferation.
This study introduces a novel dependency-aware variational causal discovery framework that integrates multi-omic data to uncover a specific mitochondrial-epigenetic feedback loop driving Parkinson's disease pathology, offering new actionable therapeutic targets by resolving cyclic regulatory mechanisms previously obscured by traditional acyclic assumptions.
This study demonstrates that a vacuum-assisted floral-bud transformation method successfully generated transgenic tomato plants expressing the defensin NaD1, which exhibited durable resistance to *Fusarium oxysporum* f. sp. *lycopersici* by establishing a tissue-coordinated defense mechanism involving localized oxidative reinforcement in roots and the preservation of photosynthetic function in shoots.
This study reveals that in *Ranunculus sceleratus*, gene duplication and *cis*-regulatory evolution have rewired the canonical AGAMOUS-WUSCHEL developmental module, transforming AG from a repressor into an activator of WUSCHEL to drive the production of numerous carpels.
Maintaining target perceived exertion during high-intensity interval training in the heat resulted in similar thermal and cardiovascular strain between active and passive recovery, though active recovery necessitated greater work rate reductions and led to comparable decreases in maximal aerobic capacity regardless of recovery mode.
This study demonstrates that human umbilical cord mesenchymal stem cell-derived extracellular vesicles loaded with MYD88-silencing siRNA effectively alleviate sepsis-associated encephalopathy by targeting microglia and vascular endothelial cells to restore blood-brain barrier integrity, suppress neuroinflammation, and improve cognitive outcomes in a murine model.
This study presents a physics-informed, explainable machine learning framework that integrates optical and biological features to predict wavelength-dependent neuronal modulation, achieving modest predictive accuracy for firing rates and higher accuracy for membrane potential while providing calibrated uncertainty estimates for future experimental validation.
B-REAL is a pose-free, real-time behavior classification platform that enables closed-loop neuroethology experiments with minimal annotation and standard hardware by mapping raw video to behavior faster than frame rates, outperforming established methods even on rare behaviors.