🧬 Category

q-bio

3726 papers

🧬 biology

Mouse models of activity-based anorexia and binge-eating disorder show distinct patterns of intestinal barrier dysfunction and immune dysregulation

This study demonstrates that mouse models of activity-based anorexia and binge-eating disorder exhibit distinct, opposing patterns of intestinal barrier dysfunction and immune dysregulation, with the anorexia model showing immunosuppression and specific tight junction downregulation, while the binge-eating model displays a pro-inflammatory profile and broader junctional disruption.

Petra Prochazkova, Helena Knotkova, Janet Luthar, Radka Roubalova, Michal Kraus, Toghrul Naghiyev, Enrico Patrono, Helen (…)2026-09-09
🧬 biology

SPRINT enables spatial proteomic profile reconstruction through multimodal fusion of histology and transcriptomics

SPRINT is a multimodal computational framework that reconstructs spatial proteomic profiles by fusing spatial transcriptomics and H&E histological images, thereby overcoming the limitations of single-modality methods to accurately infer protein distributions, support cross-species analysis, and enhance tissue domain characterization.

Yadong Wang, Yuzhi Sun, Xian Liu, Tianyi Zhao2026-09-09
🧬 biology

From population evidence to validation-ready candidates: prioritizing tobacco-related nitrosamines in cervical cancer

This study establishes a population-anchored evidence-ranking framework that integrates NHANES epidemiological data with multi-omics screening to prioritize NNN, N-nitrosodimethylamine, and NNK as the most promising tobacco-related nitrosamines for mechanistic validation in cervical cancer, without claiming definitive compound-specific causality.

Pengbo Zhao, Huixia Lu2026-09-09
🧬 biology

Activity of Phytochemically Characterized Noomi Basra Extracts Against Planktonic and Biofilm Candida albicans

Phenolic-rich cold ethanol extracts of Noomi Basra (Citrus aurantifolia) demonstrate superior, dose-dependent antifungal activity against both planktonic and biofilm forms of Candida albicans compared to hot water and hot hexane extracts, suggesting their potential as effective treatments for Candida infections.

Amin M Omar, Mohammad AA Al-Najjar, Kenza Mansoor, Patricia Nadworny, Luay Abuqatouseh, Muna Barakat, Ruaa M Alalwani, S (…)2026-09-09
🧬 biology

The necrotic niche is a lipid reservoir coupling tumour fitness to metabolic vulnerability

This study reveals that aggressive glioblastoma cells actively scavenge lipids from necrotic debris to fuel tumor growth and radioresistance, creating a metabolic vulnerability where co-targeting lipid droplet buffering and ferroptosis defense mechanisms triggers lethal cell death.

Mattias Belting, Hugo Talbot, Myriam Cerezo-Magaña, Euisuk Han, Darko Tamindzic, Emma Gustafsson, Axel Boukredine, Feder (…)2026-09-09
🧬 biology

Clonal CD8 T cells link peripheral and intrathecal immunity in ALS4 progression: a multiomics reference for ALS

By integrating multiomics profiling of peripheral blood and cerebrospinal fluid in the slowly progressive ALS4 subtype, this study reveals a clonally expanded CD8+ T cell trajectory that links systemic and intrathecal immunity and parallels clinical disease progression over decades.

Laura Campisi, Marina Terekhova, Rima Melhem, Carisa Zeng, Jessie Martin, Tanya Lizbeth Joseph, Pavla Bohacova, Melina J (…)2026-09-09
🧬 biology

Transcriptomic and Genomic Insights into HSP-Mediated Protein Homeostasis in Ulmus parvifolia under Temperature Stress

This study elucidates the molecular mechanisms of temperature adaptation in *Ulmus parvifolia* by integrating transcriptomic and genomic analyses to reveal tissue-specific stress responses and the significant expansion of the HSP gene family, particularly HSP70 and HSP40, as central drivers of heat tolerance through protein homeostasis.

Yun-Zhou Lyu, Chi-jie Yin, Xiao-Yun Dong, Pu Wang, Li-Bin Huang, Zhao-lin Qiu, Gang Wang, Dezong Sui2026-09-09
🧬 biology

A Continuous Constraint-by-Timing Landscape in Autism Common-Variant Risk Genes Without Identifiable Discrete Subtypes

This study analyzes autism common-variant risk genes using five continuous biological features and demonstrates that they form a continuous, unevenly dense landscape defined by evolutionary constraint and developmental timing, rather than distinct discrete subtypes that remain stable across varying analytic thresholds.

Noah Berley, Stephen Becker, Michael Stallings2026-09-09
🧬 biology

A Tensor Network Framework for Interpretable Graph Analysis of Brain Networks

This paper introduces a quantum-inspired tensor network framework that classifies brain disorders using structural MRI data while extracting interpretable, stable higher-order feature interactions mapped onto weighted graphs, revealing consistent neural hubs and a hierarchical relationship between schizophrenia and bipolar disorder.

Domenico Pomarico, Giuseppe Magnifico, Alessandro Grecucci, Loredana Bellantuono, Jesus M. Cortes, Marianna La Rocca, Al (…)2026-09-09