5841 papers
HP-GSBS is an open-source, mathematically reformulated implementation that dramatically accelerates Greedy State Boundary Search for neural activity analysis by leveraging reusable interval statistics and multi-backend execution, achieving speedups of up to 1,730x while maintaining numerical precision and reproducibility.
Researchers engineered a protein cage variant (AaLS-POF) that undergoes rapid, reversible structural transitions between closed and open states in response to phosphate, enabling non-destructive cargo manipulation and providing a blueprint for designing stimulus-responsive nanocarriers.
This study demonstrates that the expanded dynamic range observed in sensory organs, compared to single neurons, is an emergent property of scale-free networks of Hodgkin-Huxley neurons, where the dynamic range increases with network size.
This study utilizes a network analysis of 810 college students to reveal that sleep procrastination and impulse control are central to short-video addiction, while highlighting the bridging roles of physical exercise and health attitudes and identifying gender-specific patterns in these interconnected health behaviors.
This study demonstrates that while forestry cover drives the turnover of raptor communities from grassland specialists to generalists, landscape heterogeneity is the primary factor causing a coupled decline in the taxonomic and functional diversity of diurnal raptors in the Mesopotamian Pampas, highlighting the critical need to preserve extensive native open habitats.
This study reveals that normal mucosal fibroblasts undergo a spatially organized remodeling into distinct cancer-associated fibroblast states during early colorectal cancer invasion, with flatter tumors exhibiting more extensive progression toward tumor-promoting fibroblast states that facilitate earlier submucosal invasion.
This study establishes tobacco callus as a novel, low-cost green-manufacturing platform for synthesizing β-ionone via endogenous carotenoid cleavage, demonstrating that the engineered biomass can be directly incorporated into heated tobacco products to enhance aroma and flavor without the need for extraction.
This study reveals that HSV-1 rapidly induces eIF4E phosphorylation via the ICP0-Mnk1 and Us3-mTORC1 pathways to facilitate early viral entry by selectively upregulating host membrane factors ITGB2, CD63, and TSPAN3, while also exacerbating oxidative stress, thereby identifying p-eIF4E as a promising host-targeted therapeutic strategy.
This study demonstrates that structure-based drug–drug interaction prediction models relying on Morgan fingerprints and physicochemical descriptors suffer from significant overestimation of performance due to flawed negative sampling and identity leakage, ultimately revealing that such models struggle to generalize to unseen drug pairs and require explicit uncertainty handling to be reliable.
This study demonstrates that intramuscular immunization with a CpG-adjuvanted heat-inactivated *Cryptococcus neoformans* mutant (HK-fbp1) elicits robust, sterilizing immune protection against pulmonary infection and dissemination through a coordinated CD4⁺ T-cell response dependent on IFN-γ, offering a promising vaccine strategy even for immunocompromised hosts.