5841 papers
This paper presents a multiscale mathematical modeling tool that couples macro-scale compartment-based bioreactor hydrodynamics with micro-scale kinetic metabolic models to simulate the dynamic two-way interactions between environmental gradients and cellular responses, thereby improving bioprocess design, control, and scale-up.
This study presents a high-resolution single-nucleus and spatial transcriptomic atlas of the human gravid myometrium that overcomes previous limitations in analyzing smooth muscle cells, revealing distinct cell subtypes, a functional FSHR signaling axis, and a pre-existing structural predisposition to uterine atony characterized by ENAH-driven cytoskeletal reorganization, thereby offering new mechanistic insights and therapeutic avenues for postpartum hemorrhage.
This study utilized a cost-effective, high-throughput amplicon sequencing approach to characterize insecticide resistance alleles and genetic diversity in *Anopheles gambiae* s.l. populations across Ghana, identifying both known and novel mutations while revealing high gene flow that supports the development of targeted vector control strategies.
This study identifies a conserved thalamic astrocytic pathology that emerges during the latent period after traumatic brain injury and serves as a key driver and translational marker for the development of post-traumatic epilepsy in both mice and humans.
This paper synthesizes opportunistic visual records to document the diverse, context-dependent anti-predator behaviors of lowland tapirs when confronted by free-ranging domestic dogs, highlighting that dogs often continue their pursuit even after the tapirs enter the water.
By applying drift-diffusion modeling to twelve diverse datasets, this study reveals that past actions consistently bias subsequent decisions by shifting the initial decision state away from the required response and lowering the evidence threshold for commitment, thereby compromising adaptive behavior when past and present demands overlap.
This study synthesizes and curates public mitochondrial sequence data for milkfish (*Chanos chanos*) across three markers to establish a reproducible baseline of genetic diversity, revealing high resolution in the D-loop region, evidence of historical population expansion, and significant geographic gaps that inform future research directions.
This study demonstrates that while species identity and site structure primarily govern genomic diversity variance in saproxylic beetles, distinct components are shaped by different drivers: heterozygosity aligns with contemporary host-tree associations, whereas nucleotide diversity reflects shared evolutionary history.
This study identifies gut-associated bacteria from the German cockroach (*Blattella germanica*), notably *Pseudomonas* sp. strain AYA1 and *P. mohnii* (the latter being the first reported isolation from cockroaches), as sources of antimicrobial activity against multidrug-resistant human pathogens, suggesting their potential for developing novel therapeutic agents.
This study establishes a scalable platform of vascularized human brain organoids that recapitulates the neurovascular unit and blood-brain barrier, enabling the investigation of human-specific BBB biology, development, and neurovascular diseases through in vitro and in vivo models.