1498 papers
This study demonstrates that ligand binding drives ACKR3 to form nanoclusters on T cells, which actively organize CXCR4 into heterocomplexes to attenuate CXCR4-mediated Gαi signaling, revealing a novel mechanism by which ACKR3 fine-tunes chemokine responses beyond its role as a scavenger.
This study uses an epidemiological model to demonstrate that while sub-optimal response of Onchocerca volvulus to ivermectin can hinder elimination even with biannual mass drug administration in hyperendemic regions, switching to moxidectin offers a viable path to achieving transmission elimination.
This study utilizes COI DNA barcoding on 508 marine fish specimens from the East Coast EEZ of Peninsular Malaysia to reveal 225 species, identify three new regional records, and uncover cryptic diversity within five species, thereby establishing a comprehensive reference library to support biodiversity assessment and conservation in the South China Sea.
This study demonstrates a host-informed engineering strategy in *Komagataella phaffii* that combines CRISPR-Cas9 genome editing with transcriptomic analysis to overcome synthetic lethality and growth defects, thereby enabling the production of human biantennary N-linked glycans.
By investigating community assembly mechanisms across multiple spatial scales in a primary Hainan Island rainforest, researchers developed a scale-dependent restoration strategy that successfully transformed 400 hectares of aged rubber plantations into a high-diversity tropical forest dominated by native species, offering an effective framework for global rainforest restoration and climate change mitigation.
This study utilizes a closed-loop core-conductor model with realistic nociceptor kinetics to demonstrate that single-fiber ephaptic crosstalk is insufficient to explain dynamic mechanical allodynia, whereas multi-fiber spatial summation emerges as a plausible mechanism capable of generating significant subthreshold depolarization.
This study identifies the tumor-intrinsic factor Ist1 as a critical regulator of immune evasion in pancreatic cancer that restricts IFNγ responsiveness by controlling the membrane stability of the IFNγ receptor, thereby revealing a novel therapeutic target for sensitizing tumors to CD8+ T-cell killing.
This study reveals significant functional heterogeneity among *Anacamptis morio* orchid mycorrhizal fungi isolated from Northern Italy, demonstrating that strain-specific variations in thermal resilience, metabolic profiles, and symbiotic germination capacity suggest a diverse portfolio of symbionts is crucial for orchid performance under varying developmental and environmental conditions.
This study describes five novel *Vogesella* species (*V. denitrificans*, *V. rivulicola*, *V. oligotrophica*, *V. montanilacustris*, and *V. limnetica*) isolated from freshwater environments, characterizing their genomic diversity, phylogenetic relationships, and distinct ecological adaptations related to indigoidine synthesis and nutrient cycling.
This study presents the first nuclear genome assemblies for three African blackfly species using a hybrid sequencing approach, providing a foundational resource to address species delimitation challenges in the *Simulium damnosum* complex and to advance the understanding of genome evolution and adaptation in these vectors of onchocerciasis.