5843 papers
This study establishes a scalable platform of vascularized human brain organoids that recapitulates the neurovascular unit and blood-brain barrier, enabling the investigation of human-specific BBB biology, development, and neurovascular diseases through in vitro and in vivo models.
This study introduces SHAPE, a novel method that leverages routine targeted ctDNA sequencing to integrate genomic and fragmentomic features for highly accurate, biologically interpretable prediction of cancer tissue-of-origin, potentially extending the clinical utility of existing assays without requiring additional sequencing.
This study demonstrates that perinatal disruption of the maternal microbiome selectively reduces Alzheimer's disease pathology in female offspring by reprogramming microglial metabolism and GPCR signaling pathways, thereby reversing the sex-specific susceptibility patterns typically observed with postnatal microbiome manipulations.
This study reveals that despite the Campanulaceae family's reputation for extensive plastome rearrangements, the Lobelia and Diastatea species in the Mexican Transition Zone exhibit highly conserved genome structures with only minor, species-specific variations, while phylogenetic analyses confirm the non-monophyly of section Stenotium.
This study identifies the long noncoding RNA MALAT1 as a critical permissive regulator of estrogen-driven proliferation in hormone receptor-positive breast cancer, demonstrating that its depletion suppresses growth and induces cell death by disrupting the ME3-COX-2 axis.
The study introduces HiCAggR, a Bioconductor package that leverages high-resolution aggregation of Hi-C data to distinguish insulators from enhancers by quantifying their ability to block promiscuous long-range enhancer-promoter contacts, revealing that insulator depletion leads to aberrant contacts and widespread gene deregulation.
This study reveals that mammalian hemopexin taken up by blood-feeding dipterans retains its heme-scavenging activity to protect vectors from heme toxicity and maintain gut homeostasis, thereby inadvertently promoting the development and transmission of parasites like *Plasmodium* and *Leishmania*.
This paper demonstrates that while mutation-free replicator systems lose memory of environmental sequences over time, the introduction of mutation paradoxically enables a population to retain and reconstruct the ordered history of past environments by facilitating the decoding of evolutionary flows.
This study introduces a response-centered machine-learning framework that integrates biological context and cellular response programs into a Conserved Response Axis (CRA), significantly improving the prediction of nanoparticle biosafety and recovery across diverse neurological systems beyond what material properties alone can achieve.
This study demonstrates that scaffold geometry dictates human bone marrow-derived mesenchymal stem cells' sensitivity to specific biophysical stimuli, but that combining intermittent hydrostatic pressure and pulsed electromagnetic field stimulation overcomes these geometric limitations to synergistically promote early osteogenesis through complementary molecular pathways.