q-bio papers | Gist.Science

Scaffold Geometry Governs Mechanobiological Responses to Combined Biophysical Stimulation in Human Bone Tissue-Like Models

This study demonstrates that scaffold geometry dictates human bone marrow-derived mesenchymal stem cells' sensitivity to specific biophysical stimuli, but that combining intermittent hydrostatic pressure and pulsed electromagnetic field stimulation overcomes these geometric limitations to synergistically promote early osteogenesis through complementary molecular pathways.

Lia Rimondini, Farah Daou, Stefano Gabetti, Shahd Alahmad, Beatrice Masante, Elisa Scatena, Carlotta Achille, Cristina B (…)2026-10-23

🧬 biology

A Kinematic and Biomechanical Analysis of Spatial Optimization and Energy Dissipation in the Ballistic Seed Dispersal of Loropetalum chinense

This paper analyzes the kinematic and biomechanical efficiency of *Loropetalum chinense* seed dispersal, highlighting how wind forces and natural classification constraints optimize trajectory while biochemical and structural features protect seeds from impact damage.

Shaurya Srivastava2026-10-23

🧬 biology

Neutral Morphological Masking: Constructive Neutral Evolution of Chiral Scaffolds for Information-Maintaining Artificial Cells

This paper proposes a revised framework for artificial cells that replaces the assumption of designed robustness with Constructive Neutral Evolution, demonstrating how random, neutral structural mutations in chiral scaffolds can inadvertently accumulate interlocking masks that protect information-carrying states from environmental degradation.

Leon Sandler2026-10-23

🧬 biology

Morphological and demographic characteristics of the grey hamster (Nothocricetulus migratorius) across lowland and foothill landscapes of the South Caucasus

This study analyzes morphological and demographic variations of the grey hamster (*Nothocricetulus migratorius*) across lowland and foothill landscapes in the South Caucasus using extensive long-term trapping data, revealing significant spatial, temporal, and morphometric differences between populations in Nagorno-Karabakh and Armenia.

Lusine G. Aydinyan¹, Tigran A. Hayrapetyan², Hasmik G. Khachatryan¹, Valodya S. Mirzoyan², Karine V. Balayan³, Vahram T. (…)2026-10-23

🧬 biology

The fallacy of the national average in structured populations: clinical and population genomics across 9,768 Indian genomes

This study demonstrates that analyzing 9,768 Indian genomes across 83 distinct subpopulations, rather than using a national average, is essential to accurately identify rare variants, resolve clinical artifacts, and uncover medically critical loss-of-function alleles that are otherwise obscured by population stratification.

Atanu Dutta, Soumyajit Mondal2026-10-23

🧬 biology

The Existence of the Halmahera Walking Shark (Hemiscyllium Halmahera), How are Coral Reefs as the Primery Habitat in Maitara Small Island Sea. North Maluku. Indonesia?

This study confirms that the endemic Halmahera walking shark thrives in the coral reef ecosystems of Maitara Island, North Maluku, where healthy coral cover and medium sand sediments positively influence the species' morphometrics and distribution.

Nebuchadnezzar Akbar, Yunan Gilang Restu, Abdul Ajiz Siolimbona, Firdaut Ismail, Irmalita Tahir, Abdurrachman Baksir, Ru (…)2026-10-23

🧬 biology

ac4C Info: A database to parse N4-acetylocytidine(ac4C) epitranscriptome in multiple species

The paper introduces ac4C Info, a comprehensive web platform that integrates databases for ac4C modification sites and disease-associated SNPs with analytical tools for prediction and variant impact evaluation to facilitate the study of N4-acetylcytidine epitranscriptomes across multiple species.

Kang Zhang, Da Sun, Zimu Li, Jihong Xing, Jingao Dong2026-10-23

🧬 biology

Polysaccharide from Phormidium persicinum (Reinke) Gom. promotes neuronal differentiation and mitigates hypoxia-induced neuronal disruptions in vitro

This study demonstrates that a crude polysaccharide extracted from the marine microalga *Phormidium persicinum* promotes neuronal differentiation and mitigates hypoxia-induced metabolic disruptions in SH-SY5Y cells, highlighting its potential as a therapeutic agent for neurodegenerative disorders.

Sanjivani Satpute, Thangajyothi Nadar, Kishan Kannaujiya, Akshay Bagwe, Manjushri Deodhar, Bharatbhushan Sharma2026-10-23

🧬 biology

MOET-assisted CRISPR/Cas9-mediated MSTN genome editing in caprine embryos by electroporation and embryo transfer

This study demonstrates the successful integration of MOET with CRISPR/Cas9 RNP electroporation to achieve targeted MSTN gene editing in caprine embryos, resulting in the birth of a fetus with confirmed gene cleavage.

Shiva Pratap Singh, Juhi Pathak, Manisha Pathak, Anjana Goel, Yogesh Kumar Soni, Manish Kumar Chatli2026-10-23

🧬 biology

Back to roots: a phylogeographic assessment of the refugial mosaic of Western Eurasian Fagus L. (Fagaceae) in the Caucasus

This study utilizes fine-scale plastid sequencing of 252 beech populations to reveal that the Caucasus serves as a complex refugial mosaic preserving ancient, pre-Pliocene maternal lineages with distinct demographic histories between the Black and Caspian Sea drainage systems, underscoring the critical role of chloroplast DNA in conserving these unique evolutionary trajectories.

Jana Ekhvaia, Tamar Jolokhava, Arsen Bakhia, Aleksandre Gavashelishvili, Marco Cosimo Simeone, Guido W Grimm, Thomas Den (…)2026-10-23

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