1498 papers
This study demonstrates that SIRT2 promotes spinal cord injury repair by inhibiting ferroptosis through the activation of the p53/Nrf2 pathway, thereby reducing iron overload and lipid peroxidation.
This study utilizes integrated bioinformatics analysis of pancreatic islet transcriptomes to identify GLP1R as a key therapeutic hub gene in Type 2 Diabetes Mellitus and proposes the repurposing of FDA-approved drugs Glimepiride and Linagliptin as high-affinity candidates for further preclinical development.
This study employs a cross-study transcriptomic meta-analysis to identify conserved molecular signatures in *Pseudomonas aeruginosa* biofilms, revealing that antibiotic tolerance is driven by coordinated translational reprogramming, metabolic adaptation, and the activation of tailocin-associated contractile systems.
SEMA is a novel framework that integrates spatial context into pathway enrichment analysis, outperforming existing methods to reveal critical spatially resolved biological insights, such as metabolic activities near tertiary lymphoid structures and fibroblast-mediated immune regulation, across diverse tissue and cancer datasets.
This study reveals that distinct evolutionary forces shape the human genome's short tandem repeat landscape, identifying a subset of conserved non-CG motifs that are specifically enriched in pancreatic beta-cell genes and exhibit altered expression and methylation patterns in type 1 and type 2 diabetes, respectively, suggesting their role as condition-dependent regulatory elements in beta-cell dysfunction.
This systematic review of sixteen studies reveals that unengineered landfill leachate and soil harbor diverse, highly metal-tolerant bacteria with promising bioremediation potential, yet their co-occurrence with antibiotic resistance and pathogenicity presents significant human health risks requiring further validation and standardized assessment.
This study demonstrates that an ultrasound-mediated, enzyme-free passaging system preserves the extracellular matrix and adhesion structures of mesenchymal stromal cells, thereby significantly suppressing procedure-induced extrinsic aging and maintaining cell quality and functionality compared to conventional trypsin-based methods.
This study utilizes phylogenetic and structural analyses of proteobacterial P450s to propose that CYP74 clan proteins are the ancestral lineage of the superfamily, characterized by a conserved nine-amino-acid cysteine pocket feature that was progressively lost during evolution to facilitate aerobic metabolism and redox partner interactions.
This study demonstrates that among adipose tissue, bone marrow, and Wharton's jelly sources, bone marrow-derived mesenchymal stromal cells exhibit superior chondrogenic potential, showing the strongest collagen type II deposition and gene expression when cultured in chondrogenic medium with reduced platelet lysate.
This study demonstrates that chronic oxidative stress in human myometrial cells drives molecular remodeling and genomic alterations, including MED12 mutations, providing mechanistic evidence for a causal role of redox imbalance in the initiation of uterine leiomyomas.