1498 papers
This exploratory study demonstrates that museum-based storytelling is a feasible occupation-based task for assessing neurophysiological engagement in older adult-caregiver dyads, revealing expected alpha power modulation during social interaction despite weak associations with cognitive scores and modest dyadic neural synchrony.
This study demonstrates that the human-specific expansion of Olduvai (DUF1220) protein domains promotes brain evolution and neoteny by dosage-dependently suppressing mitochondrial metabolism, which delays cellular maturation and extends neurogenesis to increase neuron production.
This study identifies the vacuolar MATE transporter DTX39 as the key mediator of high-level indolic glucosinolate accumulation in *Arabidopsis* through a proton-anion exchange mechanism, thereby enhancing the plant's chemical defense system.
This study characterizes the genome of the hedgehog-associated mecC-MRSA CC599 lineage, revealing its zoonotic origin, specific virulence factors, and increasing prevalence in human clinical isolates, which suggests a potential for cross-species transmission.
The Korea Biobank Array v2.0 is a population-optimized genotyping platform developed using East Asian whole-genome sequencing data that bridges the gap between cost-effective genotyping and comprehensive variant coverage, thereby significantly enhancing rare variant detection, imputation accuracy, and precision medicine applications for the Korean population.
This study presents an integrated differentiation strategy that generates both 2D cortical monolayers and 3D organoids from a single iPSC batch to create a versatile, scalable platform for modeling juvenile Huntington's disease, effectively recapitulating key neurodevelopmental and neurodegenerative phenotypes while reducing experimental variability and resource consumption.
This study demonstrates that causal inference relies on the functional coordination of two dissociable neural systems, where the hippocampus constructs a map of causal relations under the control of the inferior frontal sulcus, which encodes an abstract world model to infer unobserved causal connections.
This study reveals that human heart failure with preserved ejection fraction (HFpEF) is characterized by a distinctive accumulation of diverse lipid species in the myocardium that is not driven by obesity alone, differs significantly from heart failure with reduced ejection fraction (HFrEF), and is not accurately replicated by common preclinical animal models.
This study introduces an Effort-based Delay Discounting paradigm to demonstrate that high cognitive effort significantly attenuates the devaluation of delayed rewards, suggesting that willpower failures stem from a specific breakdown in integrating effort and time costs rather than simple cognitive limitations.
This study demonstrates that using base editing to introduce a premature termination codon specifically in exon 7 of the glutamine synthetase gene creates a complete knockout that yields a high-viability, high-productivity CHO cell line for antibody manufacturing, revealing that the position of the termination codon is a critical determinant of cellular phenotype.