1504 papers
The Korea Biobank Array v2.0 is a population-optimized genotyping platform developed using East Asian whole-genome sequencing data that bridges the gap between cost-effective genotyping and comprehensive variant coverage, thereby significantly enhancing rare variant detection, imputation accuracy, and precision medicine applications for the Korean population.
This study presents an integrated differentiation strategy that generates both 2D cortical monolayers and 3D organoids from a single iPSC batch to create a versatile, scalable platform for modeling juvenile Huntington's disease, effectively recapitulating key neurodevelopmental and neurodegenerative phenotypes while reducing experimental variability and resource consumption.
This study demonstrates that causal inference relies on the functional coordination of two dissociable neural systems, where the hippocampus constructs a map of causal relations under the control of the inferior frontal sulcus, which encodes an abstract world model to infer unobserved causal connections.
This study reveals that human heart failure with preserved ejection fraction (HFpEF) is characterized by a distinctive accumulation of diverse lipid species in the myocardium that is not driven by obesity alone, differs significantly from heart failure with reduced ejection fraction (HFrEF), and is not accurately replicated by common preclinical animal models.
This study introduces an Effort-based Delay Discounting paradigm to demonstrate that high cognitive effort significantly attenuates the devaluation of delayed rewards, suggesting that willpower failures stem from a specific breakdown in integrating effort and time costs rather than simple cognitive limitations.
This study demonstrates that using base editing to introduce a premature termination codon specifically in exon 7 of the glutamine synthetase gene creates a complete knockout that yields a high-viability, high-productivity CHO cell line for antibody manufacturing, revealing that the position of the termination codon is a critical determinant of cellular phenotype.
This study reveals that SUMOylation of HSF1 is essential for terminating the proteotoxic stress response by promoting the disassembly of nuclear stress bodies and releasing trapped splicing factors, thereby enabling the timely restoration of normal splicing patterns and cellular homeostasis.
This study analyzes behavioral data from 81 participants to confirm a robust Stroop interference effect, demonstrating significantly slower reaction times and high accuracy in incongruent conditions compared to congruent ones, with a mean interference of 106 ms and a large effect size.
This study identifies ANKRD13D as a novel prognostic biomarker and therapeutic target in colorectal cancer that drives tumor progression by interacting with and stabilizing p-ERK to activate the MAPK signaling pathway.
In early Parkinson's disease, individual variations in working memory-related neural activation are primarily driven by caudate integrity, specifically showing a stronger inverse correlation with iron load than a positive correlation with dopamine transporter density, rather than by overt group-level differences compared to healthy controls.