3726 papers
This study presents the first high-quality assembly and comparative analysis of *Paliurus hemsleyanus* organellar genomes, integrating transcriptomic data to identify key nuclear-organelle crosstalk modules and hub genes that elucidate the species' evolutionary trajectory and provide molecular targets for future breeding.
This preclinical study demonstrates that a novel micronutrient formulation (F1), either alone or combined with antioxidant compounds (F2), significantly reduces DNA damage in human lymphocytes under micronutrient-deficient conditions without compromising safety in replete environments, suggesting its potential to improve genome integrity in individuals with subclinical deficiencies.
This study utilizes genome-scale CRISPRi Perturb-seq in primary human CD4⁺ T cells to identify an LKB1–PKA–SIK transcriptional module that regulates the adenosine-generating enzyme CD9 (ENTPD1), linking this causal pathway to methotrexate response and Treg suppression in rheumatoid arthritis.
This study demonstrates that Creek Chub in West Michigan accumulate significantly higher levels of *E. coli* on their mucus compared to other fish species, with bacterial loads influenced by discharge rather than water quality, and confirms that handling these fish can transfer bacteria to humans, highlighting the need for improved hygiene practices in recreational fishing.
This study reveals that anthropogenic microfibers, primarily cotton, are pervasive in Antarctic benthic invertebrates from Terra Nova Bay, with filter-feeding scallops accumulating higher abundances than deposit-feeding sea urchins, highlighting how feeding strategies influence exposure pathways even within the protected Ross Sea region.
This study reveals that the artificial sweetener acesulfame potassium and the natural sweetener stevia differentially modulate uropathogenic *Escherichia coli* by distinct physiological mechanisms, with acesulfame potassium specifically enhancing bacterial motility and stevia serving as a usable carbon source to support growth.
A study of 663 breast cancer patients in southwestern Colombia revealed a 9.20% prevalence of heterozygous variants in intermediate-to-low penetrance FANC-family genes (excluding BRCA1/2 and related high-risk genes), with FANCM, FANCA, and FANCD2 being the most frequently affected and showing a potential founder effect, thereby supporting their inclusion in routine genetic testing and the development of Latin American genomic repositories.
This study utilizes transcriptomic analysis to reveal that single-tail and twin-tail goldfish morphotypes exhibit distinct immune responses to *Ichthyophthirius multifiliis* infection, characterized by thousands of differentially expressed genes enriched in critical immune signaling pathways, thereby highlighting the biological costs of artificial selection on disease resistance.
This study found that among male college students, the frequency of physical activity (up to four days per week) does not significantly enhance performance in visual inhibition or divided attention tasks compared to non-active peers.
This study establishes a physiologically relevant 3D multi-lineage human liver organoid platform for fibrosis modeling and drug screening, identifying the novel aspirin derivative AS191 as a potent therapeutic agent that mitigates hepatic fibrosis by inhibiting the non-canonical TGF-β/PI3K/AKT signaling pathway.