1504 papers
This study demonstrates that Dlx5-6-dependent GABAergic programs are critical for organizing hypothalamic circuits that regulate systemic metabolism, as their deletion in mice leads to developmental remodeling of AgRP/NPY pathways, altered hormonal responsiveness, and a unique metabolic phenotype characterized by reduced energy expenditure but improved insulin sensitivity.
This study identifies a novel extracellular allosteric pocket in the KV1.3 channel, defined by peripheral residues that enable a unique "non-contact selectivity" mechanism, thereby establishing a distinct chemical space for the rational design of selective immunomodulators.
MiShape is a novel framework that leverages a learned 3D shape prior derived from high-resolution Electron Microscopy to accurately reconstruct 3D mitochondrial morphology from single 2D fluorescence microscopy images, outperforming existing methods in geometry and topology metrics.
This paper benchmarks classical, hybrid, and quantum annealing workflows on a structured binary control QUBO derived from greenhouse heater scheduling, finding that while classical and simulated quantum methods consistently yield near-optimal solutions, current quantum hardware and hybrid solvers do not yet demonstrate a performance advantage over classical baselines.
This paper presents a theoretical framework demonstrating that mirror-image life forms, despite their molecular feasibility, would likely face severe ecological constraints and fail to establish themselves in natural ecosystems due to nutrient incompatibility and competitive exclusion by existing biota.
This case report documents three distinct anatomical variations of the musculocutaneous nerve observed in an anatomy laboratory, including two instances of its complete absence with functional compensation by the median nerve and one instance of fusion with the median nerve after innervating the coracobrachialis, all of which hold significant clinical implications for diagnosing upper limb sensory and motor deficits.
The paper introduces CURIA, a novel pipeline that combines synteny-constrained genome alignment with RiNALMo RNA foundation model embeddings to improve cross-species non-coding RNA annotation by identifying localized embedding-supported regions that complement conventional sequence conservation metrics.
This study presents a comprehensive single-cell and spatial atlas of the tumor microenvironment across high-risk pediatric sarcomas, defining distinct cell states and twelve TME archetypes to reveal conserved and entity-specific multicellular niches that provide a framework for developing rational immunotherapies.
This study employs a proteome-wide reverse molecular docking screen against high-confidence AlphaFold2 models to identify mitochondrial ATP synthase subunit β as a high-confidence, structurally plausible molecular target of the potent macrofilaricidal glycyrrhetinic acid analog 6a in *Brugia malayi*, providing computational evidence that bridges the gap between its observed efficacy and previously unknown mechanism of action.
This study demonstrates that rehabilitated juvenile Baltic grey seals rapidly adapt to local conditions by exhibiting distinct diel diving patterns, characterized by deeper, shorter daytime dives and shallower, longer nocturnal dives, which suggests successful post-release behavioral adjustment to prey distribution.