Restoring the p53--Nrf2--SIRT3--TFAM Axis via Therapeutic Epigenetic Shielding Reverses Bioenergetic Collapse and Nucleoid-Phagy Failure in Long COVID
This study proposes a systems biology framework demonstrating that Long COVID's bioenergetic collapse and chronic inflammation stem from CD147-mediated suppression of the p53--Nrf2--SIRT3--TFAM axis, which impairs mitochondrial function and nucleoid-phagy, but can be reversed through therapeutic epigenetic shielding to restore this regulatory cascade.
Original paper licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). This is an AI-generated explanation of a preprint that has not been peer-reviewed. It is not medical advice. Do not make health decisions based on this content. Read full disclaimer
Drowning in papers in your field?
Get daily digests of the most novel papers matching your research keywords — with technical summaries, in your language.