1504 papers
This study demonstrates that in fission yeast, polySUMOylation safeguards fragile ribosomal DNA during replication stress by inhibiting K63-linked polyubiquitination of the homologous recombination factor Rad52, thereby preventing its aberrant accumulation and genomic instability.
Through experimental evolution of *Burkholderia cenocepacia* CRISPRi mutants, researchers identified that phenotypic reversion to wild-type growth was caused by defects in rhamnose uptake leading to dCas9 expression loss, rather than mutations in the CRISPRi machinery itself.
The paper introduces ToxiPred, an interpretable two-tower neural network that predicts tissue-specific drug toxicity by integrating multi-omics data through a pathway-level bottleneck, enabling both accurate liability scoring and mechanistic attribution of adverse effects.
This study demonstrates that in early- and late-onset blind individuals, specific hippocampal subfield volumes (DG/CA3 and subiculum) correlate with non-visual cognitive map-based navigation performance, suggesting that distinct neural mechanisms for spatial coding are preserved and functionally reorganized in blindness despite the absence of overall volumetric differences compared to sighted controls.
This study reveals that alternative splicing generates a cardiomyocyte-specific nuclear isoform of ACSS2 (ACSS2-L) that regulates cardiac contractile gene programs by modulating H3K27 acetylation at active promoters and enhancers, thereby integrating metabolic signaling with epigenetic control to maintain heart function and prevent maladaptive remodeling.
This study analyzes *Plasmodium falciparum* msp1 sequences in Vietnam to reveal that while climatic and ecological gradients influence the magnitude of genetic diversity, they do not drive significant population subdivision, as most variation remains within cohesive parasite populations across environmental boundaries.
The study identifies Sena1, an essential mammalian intrinsically disordered protein, as a constitutive nuclear lubricant that prevents the pathological hardening of biomolecular condensates by actively resolving arrested assemblies of aggregation-prone proteins like U2af2, thereby safeguarding proteome homeostasis and ensuring proper splicing of specific introns.
This study proposes a pathway-informed stratification of major depression by demonstrating that symptom-specific genetic liabilities converge on mitochondrial metabolism and trafficking pathways previously linked to NMN-rescued aging programs, thereby supporting a biologically distinct dimensional model of the disorder.
Three experiments utilizing the Perruchet dissociation paradigm demonstrate that the progressive congruency sequence effect in the flanker task operates independently of conscious conflict expectancy, thereby challenging expectancy-based accounts of adaptive cognitive control.
This study demonstrates that environmentally relevant prenatal methylmercury exposure disrupts developmental trajectories and induces persistent, sex-specific alterations in growth, hepatic function, and inflammatory signaling in pubertal rats.