1504 papers
This study demonstrates that SHAP analysis of multi-entropy EEG features, particularly Fuzzy Entropy from the Pz channel, can effectively identify reliable biomarkers and provide clinically interpretable explanations for tree-based driver fatigue detection models, despite achieving moderate classification accuracy.
Through an integrated bioinformatics analysis of GEO datasets followed by experimental validation via real-time PCR, this study identifies STAT1 and LOX as significantly upregulated hub genes associated with poor prognosis in esophageal squamous cell carcinoma, highlighting their potential as therapeutic targets.
This study reveals that *Rhipicephalus microplus* ticks infesting cattle in Punjab, Pakistan, frequently carry multiple zoonotic bacterial pathogens, particularly *Rickettsia massiliae*, *Anaplasma phagocytophilum*, and *Ehrlichia* species, with higher infection rates observed in female ticks and significant spatial variation for *Ehrlichia*.
This study utilizes 7T fMRI and postmortem analysis to provide novel evidence that the human rostromedial tegmental nucleus (RMTg) is activated during nociceptive processing and exhibits functional connectivity with key mesocorticolimbic and nigrostriatal circuits, while also confirming the presence of specific molecular markers in this region.
This study demonstrates that FGF8-FGFR4 signaling promotes porcine oocyte maturation and early embryonic developmental competence by enhancing downstream phosphorylation pathways, mitochondrial function, and embryonic genome activation gene expression.
This study integrates multi-omics approaches to demonstrate that the ER-PM contact site protein SYT1 anchors the monolignol biosynthetic complex, thereby optimizing monolignol export for stress-induced lignin deposition.
This study characterizes the expression profile, structural features, and functional implications of ovarian extrachromosomal circular DNA in a rat model of polycystic ovary syndrome, revealing significantly reduced abundance and altered length distributions that offer new insights into the disease's pathogenesis and potential therapeutic targets.
This study reveals that PRMT1 drives glioblastoma stem cell tumorigenesis by asymmetrically dimethylating YBX1 at R69, which enhances its binding to and stabilization of cell cycle mRNAs to activate the AKT signaling cascade, thereby identifying this methylation axis as a promising therapeutic target for glioblastoma.
This study reveals that in female Alzheimer's disease models, the non-aromatizable androgen DHT exacerbates Tau pathology and neuroinflammation by activating a non-canonical TR4–Trem2 signaling axis in microglia, thereby elucidating a key mechanism behind the sex-specific vulnerability to the disease.
This study demonstrates that an interpretable multimodal EEG model integrating both task-evoked and resting-state features can effectively identify high social anxiety by revealing complementary neural signatures of delayed threat processing and altered self-focused attention.