5903 papers
This study identifies the long noncoding RNA MALAT1 as a critical permissive regulator of estrogen-driven proliferation in hormone receptor-positive breast cancer, demonstrating that its depletion suppresses growth and induces cell death by disrupting the ME3-COX-2 axis.
The study introduces HiCAggR, a Bioconductor package that leverages high-resolution aggregation of Hi-C data to distinguish insulators from enhancers by quantifying their ability to block promiscuous long-range enhancer-promoter contacts, revealing that insulator depletion leads to aberrant contacts and widespread gene deregulation.
This study reveals that mammalian hemopexin taken up by blood-feeding dipterans retains its heme-scavenging activity to protect vectors from heme toxicity and maintain gut homeostasis, thereby inadvertently promoting the development and transmission of parasites like *Plasmodium* and *Leishmania*.
This paper demonstrates that while mutation-free replicator systems lose memory of environmental sequences over time, the introduction of mutation paradoxically enables a population to retain and reconstruct the ordered history of past environments by facilitating the decoding of evolutionary flows.
This study introduces a response-centered machine-learning framework that integrates biological context and cellular response programs into a Conserved Response Axis (CRA), significantly improving the prediction of nanoparticle biosafety and recovery across diverse neurological systems beyond what material properties alone can achieve.
This study demonstrates that scaffold geometry dictates human bone marrow-derived mesenchymal stem cells' sensitivity to specific biophysical stimuli, but that combining intermittent hydrostatic pressure and pulsed electromagnetic field stimulation overcomes these geometric limitations to synergistically promote early osteogenesis through complementary molecular pathways.
This paper analyzes the kinematic and biomechanical efficiency of *Loropetalum chinense* seed dispersal, highlighting how wind forces and natural classification constraints optimize trajectory while biochemical and structural features protect seeds from impact damage.
This paper proposes a revised framework for artificial cells that replaces the assumption of designed robustness with Constructive Neutral Evolution, demonstrating how random, neutral structural mutations in chiral scaffolds can inadvertently accumulate interlocking masks that protect information-carrying states from environmental degradation.
This study analyzes morphological and demographic variations of the grey hamster (*Nothocricetulus migratorius*) across lowland and foothill landscapes in the South Caucasus using extensive long-term trapping data, revealing significant spatial, temporal, and morphometric differences between populations in Nagorno-Karabakh and Armenia.
This study demonstrates that analyzing 9,768 Indian genomes across 83 distinct subpopulations, rather than using a national average, is essential to accurately identify rare variants, resolve clinical artifacts, and uncover medically critical loss-of-function alleles that are otherwise obscured by population stratification.