🧬 Category

q-bio

3746 papers

🧬 biology

The effects of 9-week triphasic resistance training on the lower limb strength,balance ability and 200-m sprint performance of elite female sprint canoe athletes

A 9-week triphasic resistance training program was found to be more effective than traditional strength training for enhancing lower-limb maximal strength, muscle power, and explosive strength in elite female sprint canoe athletes, although these physiological gains did not translate into significant improvements in dynamic balance or 200-m sprint performance.

Haopeng Tang, Lili Jia, Congwan Yuan, Rui Liu, Ruisen Feng, Nianhong Li2026-09-08
🧬 biology

Spatiotemporal Characterization of GSTO1 Inhibition in Postoperative Cognitive Dysfunction: Roles of Hippocampal Oxidative Stress and Neuroinflammation in Aged Mice

This study demonstrates that in aged mice, the combination of surgical trauma and pharmacological inhibition of hippocampal GSTO1 triggers a time-dependent cascade of oxidative stress, neuroinflammation, and amyloid precursor protein accumulation, ultimately leading to exacerbated postoperative spatial memory deficits.

Guangwei Huang¹, Jing Li², Hualiu Chen³, Huanhuan Ma2026-09-08
🧬 biology

L-Aspartic acid is a Core Metabolite Mediating the Anti-aging Effect of Probiotics in Caenorhabditis elegans

This study demonstrates that three specific probiotic strains extend the lifespan of *C. elegans* by modulating metabolic homeostasis, with L-Aspartic acid identified as a critical mediator that links probiotic intake to longevity through the regulation of energy metabolism via the *got-1.2* and *adk-1* pathways.

Jiayuan Cao, Yisuo Liu, Lu Jiang, Pimin Gong, Zhongxia Li, Huaxi Yi2026-09-08
🧬 biology

Single-cell and spatial transcriptomics define an R-loop-associated malignant state in intrahepatic cholangiocarcinoma and prioritize MTHFD1L

This study integrates multi-omics data to define an R-loop-associated malignant state in intrahepatic cholangiocarcinoma characterized by specific cellular interactions and metabolic adaptations, ultimately identifying MTHFD1L as a critical therapeutic target linked to one-carbon metabolism and redox homeostasis.

Haocheng Yang, Sheng Guo, Tuo Deng2026-09-08
🧬 biology

Plasma proteomic scores for body mass index generalize across multiple ancestries

This study demonstrates that plasma proteomic scores for body mass index, developed across diverse ancestries in the UK Biobank and South African cohorts, are portable and effective in predicting obesity and identifying metabolically unhealthy normal-weight individuals, thereby enhancing cardiometabolic risk stratification across global populations.

Tinashe Chikowore, Monica Muti, Yann Ilboudo, Usama Aliyu, Chengyue Zhang, Lisa Ware, Michael Chong, Lisa Micklesfield (…)2026-09-08
🧬 biology

Plasma Fibrinogen Correlates with Aβ Clearance of monocytes and AD Biomarkers in Cognitively Normal Individuals

In cognitively normal older adults, elevated plasma fibrinogen levels are significantly associated with impaired amyloid-β clearance by monocytes and higher levels of plasma Alzheimer's disease biomarkers, suggesting that fibrinogen-related monocyte dysfunction may represent an early peripheral event in the Alzheimer's disease continuum.

Sihan Chen, Min Wang, Yifei Ji2026-09-08
🧬 biology

Effects of Multi-Day Gobi Endurance Trekking on Foot Morphology in Male Adolescents

This study reveals that while multi-day Gobi endurance trekking does not significantly alter the bony foot structure of male adolescents, it induces progressive soft tissue edema in the heels and functional flattening of the medial longitudinal arch, which, combined with systemic fatigue and pain, elevates the risk of foot injury.

Jiazhi Wang, Shaowei Jia, Tingting Xian, Jieyu Wei, Tianxin Shi, Haiyun Liu, Zhenlong Liu, Jingxian Zhu, Shuang Ren2026-09-08
🧬 biology

Draft genome analysis and in vitro evaluation of probiotic-associated properties in Lacticaseibacillus paracasei UCO-100

This study characterizes *Lacticaseibacillus paracasei* UCO-100, a human gastric isolate, as a promising probiotic candidate by confirming its safety, stress tolerance, and adhesion capabilities through comprehensive genomic and in vitro analyses.

Víctor Fuentes-Barrera, Cristobal Goic, Cristian Parra-Sepulveda, Héctor Valdebenito-Navarrete, Kimberly Sánchez-Alonzo (…)2026-09-08
🧬 biology

Deciphering the ferroptosis-regulatory mechanism of Polyphyllin I in castration-resistant prostate cancer via network pharmacology, machine learning and experimental validation

This study integrates network pharmacology, machine learning, and experimental validation to demonstrate that Polyphyllin I exerts antitumor effects in castration-resistant prostate cancer by modulating ferroptosis through a multi-target network, specifically suppressing ferroptosis via IGF1R and linking immunity to ferroptosis via CSF1R.

Zhigao Mo, Xiaotao Zhou, Jinxing Liu, Qing Zhang, Maoyuan Xu, Li Ma, Nian Liu, Zhikun Liu2026-09-08