1504 papers
This study utilizes spatial lipidomics to reveal that fiber-type-specific and sex-dependent lipid remodeling in skeletal muscle occurs as an early, presymptomatic event in ALS pathogenesis, offering promising tissue and serum biomarkers for early diagnosis.
This study identifies a specific amino acid motif, termed the "CS-sequon," as the essential signal for chondroitin sulfate glycosylation, demonstrating that its insertion can confer CS modification to unmodified proteins and enhance their stability and activity across diverse species.
HiFi-ST introduces a conditional neural field framework that reconstructs continuous spatial transcriptomic expression fields by modeling spots as regional observations and integrating multiscale tissue features, thereby significantly outperforming existing methods in accuracy and enabling advanced downstream analyses like tumor microenvironment characterization.
This study demonstrates that the ethylene signaling component MaEIN2 mediates herbivory-induced chlorogenic acid accumulation in mulberry leaves, thereby linking silkworm feeding cues to enhanced plant defense and potentially supporting silkworm development.
This study demonstrates that an optimized Gradient Boosting Decision Tree ensemble, enriched with domain-specific meta-features and molecular representations, significantly improves honeybee toxicity prediction accuracy on the ApisTox dataset compared to existing benchmarks.
This study introduces DiSuCy, a curated knowledgebase of sulfur metabolism genes, to reveal the evolutionary dynamics and distinct metabolic strategies of sulfur-cycling microorganisms across diverse ecosystems, including the identification of novel taxa and non-canonical pathways in the ocean and human gut.
This study reveals that seasonal environmental fluctuations in Dinghai Bay drive parallel shifts in microbial community composition, assembly processes, and network structure, while simultaneously altering the efficiency of grazing-mediated carbon flow from phytoplankton and bacterioplankton, with phytoplankton consistently serving as the dominant carbon source.
The paper introduces WATER, a computational framework that reconstructs independent temporal gene expression trajectories to detect molecular heterochrony (gene expression mistiming) across developmental and disease contexts, revealing widespread transcriptional reorganization that traditional stage-matched comparisons overlook.
This study reveals that GPCR activation-switch architecture is not organized by ligand identity but by a coevolving structural network involving the ionic lock, Tyr5.58, and sodium-pocket residues, which utilizes diverse, lineage-specific mechanisms to stabilize the conserved DRY arginine.
This study proposes an integrated carrying capacity framework that combines ecological, biological, and social dimensions to establish evidence-based, context-specific population targets for conflict-prone threatened species, using Chinese wild Asian elephants in Yunnan as a case study to advocate for prioritizing human tolerance and aligning land-use policies with conservation goals.