🧬 biology

Mammalian Hemopexin Protects Blood-Feeding Dipterans from Heme Toxicity and Promotes Parasite Transmission

This study reveals that mammalian hemopexin taken up by blood-feeding dipterans retains its heme-scavenging activity to protect vectors from heme toxicity and maintain gut homeostasis, thereby inadvertently promoting the development and transmission of parasites like *Plasmodium* and *Leishmania*.

Joel Vega-Rodríguez, Francis de Souza Saraiva, Thiago Alves e Silva, Octavio Talyuli da Cunha, Eva Iniguez, Patricia Alv (…)2026-10-23
🧬 biology

Conserved biological response states organize nanoparticle biosafety across neurological systems

This study introduces a response-centered machine-learning framework that integrates biological context and cellular response programs into a Conserved Response Axis (CRA), significantly improving the prediction of nanoparticle biosafety and recovery across diverse neurological systems beyond what material properties alone can achieve.

sumit kumar, Renukadevi Balusamy, Davoodbasha Mubarak Ali, Irfan Ullah, Girish Birappa, Samad Abdus, Priyanka Singh, Sha (…)2026-10-23
🧬 biology

Scaffold Geometry Governs Mechanobiological Responses to Combined Biophysical Stimulation in Human Bone Tissue-Like Models

This study demonstrates that scaffold geometry dictates human bone marrow-derived mesenchymal stem cells' sensitivity to specific biophysical stimuli, but that combining intermittent hydrostatic pressure and pulsed electromagnetic field stimulation overcomes these geometric limitations to synergistically promote early osteogenesis through complementary molecular pathways.

Lia Rimondini, Farah Daou, Stefano Gabetti, Shahd Alahmad, Beatrice Masante, Elisa Scatena, Carlotta Achille, Cristina B (…)2026-10-23
🧬 biology

Neutral Morphological Masking: Constructive Neutral Evolution of Chiral Scaffolds for Information-Maintaining Artificial Cells

This paper proposes a revised framework for artificial cells that replaces the assumption of designed robustness with Constructive Neutral Evolution, demonstrating how random, neutral structural mutations in chiral scaffolds can inadvertently accumulate interlocking masks that protect information-carrying states from environmental degradation.

Leon Sandler2026-10-23
🧬 biology

Morphological and demographic characteristics of the grey hamster (Nothocricetulus migratorius) across lowland and foothill landscapes of the South Caucasus

This study analyzes morphological and demographic variations of the grey hamster (*Nothocricetulus migratorius*) across lowland and foothill landscapes in the South Caucasus using extensive long-term trapping data, revealing significant spatial, temporal, and morphometric differences between populations in Nagorno-Karabakh and Armenia.

Lusine G. Aydinyan¹, Tigran A. Hayrapetyan², Hasmik G. Khachatryan¹, Valodya S. Mirzoyan², Karine V. Balayan³, Vahram T. (…)2026-10-23
🧬 biology

The Existence of the Halmahera Walking Shark (Hemiscyllium Halmahera), How are Coral Reefs as the Primery Habitat in Maitara Small Island Sea. North Maluku. Indonesia?

This study confirms that the endemic Halmahera walking shark thrives in the coral reef ecosystems of Maitara Island, North Maluku, where healthy coral cover and medium sand sediments positively influence the species' morphometrics and distribution.

Nebuchadnezzar Akbar, Yunan Gilang Restu, Abdul Ajiz Siolimbona, Firdaut Ismail, Irmalita Tahir, Abdurrachman Baksir, Ru (…)2026-10-23