5907 papers
The paper introduces ac4C Info, a comprehensive web platform that integrates databases for ac4C modification sites and disease-associated SNPs with analytical tools for prediction and variant impact evaluation to facilitate the study of N4-acetylcytidine epitranscriptomes across multiple species.
This study demonstrates that a crude polysaccharide extracted from the marine microalga *Phormidium persicinum* promotes neuronal differentiation and mitigates hypoxia-induced metabolic disruptions in SH-SY5Y cells, highlighting its potential as a therapeutic agent for neurodegenerative disorders.
This study demonstrates the successful integration of MOET with CRISPR/Cas9 RNP electroporation to achieve targeted MSTN gene editing in caprine embryos, resulting in the birth of a fetus with confirmed gene cleavage.
This study utilizes fine-scale plastid sequencing of 252 beech populations to reveal that the Caucasus serves as a complex refugial mosaic preserving ancient, pre-Pliocene maternal lineages with distinct demographic histories between the Black and Caspian Sea drainage systems, underscoring the critical role of chloroplast DNA in conserving these unique evolutionary trajectories.
This study utilized 2,294 SNP markers to evaluate the genetic diversity and purity of 87 maize genotypes in Ethiopia, revealing that 64% of inbred lines lacked sufficient purity and required further inbreeding while identifying distinct genetic clusters to enhance breeding efficiency and seed quality control.
This study evaluates six key factors affecting environmental HPV detection in a laboratory setting, concluding that dry polyester swabs combined with dedicated viral transport media offer the most practical approach for molecular recovery, while surface material and ambient temperature are the primary determinants of detectability.
This study successfully adapted and field-validated a pesticide-specific bioindicator for South Korea's Seomjin River by integrating toxicity data from 20 indigenous species, demonstrating that controlling for organic pollution gradients reveals a robust correlation between the index and pesticide exposure that standard diversity metrics cannot detect.
This study demonstrates that personalizing gait biomechanics for lower-limb joint moments using limited subject-specific data is primarily driven by adapting the temporal waveform shape rather than the amplitude, resulting in significant prediction accuracy improvements over population-wide models.
By analyzing scRNA-seq data across multiple cancer types and treatment cohorts, this study infers clone-specific gene regulatory networks to demonstrate that tumor clones exhibit distinct regulatory architectures linked to fitness, where treatment-induced remodeling drives structural divergence yet functional convergence, ultimately revealing conserved and variable regulons associated with patient survival.
This study demonstrates that inflammatory stimuli impair myelin clearance by promoting lipid accumulation in macrophages, a process that can be mitigated by agonists of the nuclear receptors LXR, PPARγ, and RXR, suggesting these receptors as potential therapeutic targets for CNS injuries involving lipid debris.