3746 papers
This study demonstrates that chronic genotoxic and metabolic stress drive distinct yet overlapping senescence programs in human microglia, characterized by divergent regulatory pathways, mitochondrial remodeling, and unique inflammatory signatures that may differentially contribute to neurodegenerative processes.
This study demonstrates that FINO2 induces ferroptosis in HT22 neurons by inhibiting TrxR1, which prevents the reduction of PDI, thereby activating PDI oxidase to drive NOS dimerization, NO accumulation, and subsequent lipid peroxidation.
This study demonstrates that both low temperature and short-term acidic stress significantly enhance plasma membrane permeability in CHO-K1 and HEK-293E suspension cells, with CHO-K1 cells showing a particularly pronounced and persistent response to acidic conditions, thereby identifying extracellular pH as a key modulator for improving molecular delivery in biotechnological applications.
This paper proposes a T-timed Petri net framework for modeling biological neural circuits that overcomes the limitations of fixed-timestep simulations by enabling formally verifiable, deadline-guaranteed real-time execution while maintaining analytical correspondence to continuous-time dynamics, as validated through three simulated microcircuits.
This study utilizes whole-exome sequencing and in silico analysis to reveal that while B-cell lymphoproliferative disorder patients with secondary immunodeficiency share high mutational frequencies with primary immunodeficiency patients, they exhibit distinct genetic profiles characterized by a higher prevalence of mutations in combined immunodeficiency and immune dysregulation genes, as well as different patterns of inheritance and variant co-occurrence.
This study demonstrates that under a partitioned ACMG framework preventing evidence reuse, intrinsic sequence data alone is mathematically insufficient to classify missense variants as pathogenic, revealing that reducing the burden of uncertain significance requires diverse evidence types rather than improved computational predictors.
This study demonstrates that caveolin-1 (CAV1) is downregulated in cervical cancer and functions as a tumor suppressor by inhibiting cell proliferation, migration, and invasion through the downregulation of EHD2 and FSCN1.
This study reveals that a hybrid-enriched *Sphingobium* bacterium promotes maize heterosis under phosphorus deficiency by producing auxin via the indole-3-pyruvate pathway, which drives root architectural plasticity and enhances phosphorus acquisition.
This study demonstrates that age, sex, and education level significantly influence GABA and glutamate-glutamine levels in the anterior cingulate cortex of healthy subjects, highlighting the necessity of accounting for these demographic factors in MRS research.
This study demonstrates that in naturally infected chickens, increasing Marek's disease virus burden is associated with a coordinated, tissue-independent immune remodeling characterized by the suppression of antiviral cytokines (IFN-γ, IL-2) and the upregulation of inflammatory and immunoregulatory cytokines (IL-4, IL-6, IL-10, IL-17) across paired liver and spleen tissues.