1504 papers
This study presents a high-quality, multi-tissue transcriptome and expression atlas for the narrow-clawed crayfish *Astacus leptodactylus*, assembled from 37 RNA-seq samples and validated for functional completeness, thereby establishing a foundational resource for ion channel research and functional genomics in non-model crustaceans.
This study proposes a unified mechanistic framework explaining interspecific variation in vertebrate developmental radiosensitivity under chronic ionizing radiation by integrating factors such as radionuclide bioaccumulation, metabolic rate, anatomical shielding, and proliferative dynamics, based on a structured synthesis of 20 experimental studies and 9 articles.
This paper proposes a Soft Actor-Critic reinforcement learning framework integrated with a behaviorally heterogeneous S1S2IR epidemic model to dynamically optimize intervention strategies, demonstrating through COVID-19 calibration that it effectively reduces infection peaks and costs compared to static policies.
This paper proposes a wastewater surveillance method that utilizes epigenetic markers, such as DNA methylation, to monitor community-wide physiological states and public health trends by analyzing how environmental and lifestyle factors influence gene expression without altering the DNA sequence.
This paper documents a previously unreported stereotyped four-stroke scratching sequence in domestic chickens and proposes a four-tier neuro-behavioral model attributing this evolutionarily optimized foraging pattern to spinal, brainstem, and cerebellar-basal ganglia mechanisms rather than cortical cognition.
This study analyzes the TIHM home-monitoring cohort to demonstrate that pre-agitation disruption in dementia is characterized by a distinct "entropy anatomy" where irregularity metrics (sample and approximate entropy) significantly increase while long-range persistence (Hurst exponent) decreases, supporting the use of multi-feature sequences over single-metric triggers for detection.
This study leverages sex- and ancestry-stratified rare-variant gene-burden analyses across multiple cardiometabolic disorders to expand the catalog of causal gene–phenotype associations from 368 to 534, revealing that approximately one in six individuals carries risk-increasing alleles while one in nine carries protective ones.
This study demonstrates that inhibiting TAM kinase receptors in leukemia cells modulates the Axin-2/BCL2 axis to regulate intrinsic mitochondrial apoptosis, suggesting that targeting this pathway could overcome treatment resistance in chronic myeloid and acute lymphoid leukemia.
This paper proposes a comprehensive a posteriori diagnostic framework that moves beyond simple residual loss to evaluate the reliability of Physics-Informed Neural Networks for option pricing by analyzing residual-error geometry, Greek stability, and no-arbitrage constraints, demonstrating through extensive benchmarks that these structural diagnostics provide a more accurate assessment of pricing errors than residual metrics alone.
This study establishes that optimal urinary cell-free DNA preservation requires processing urine into supernatant with 10 mM EDTA, followed by storage at -80°C for long-term stability or at room temperature for up to 7 days, while avoiding high EDTA concentrations, uncentrifuged whole urine, and post-thaw secondary centrifugation.