1504 papers
In early-stage melanoma, CD8+ T cells adopt a tissue-resident memory-like phenotype to establish initial immunosurveillance, but their cytotoxic and sentinel functions are critically suppressed by co-localizing regulatory T cells, representing a key mechanism of tumor immune evasion.
This study establishes a sequence-encoded molecular grammar for intrinsically disordered protein regions that predicts and enables environmental sensitivity to hyperosmotic stress, demonstrating that specific patterning of oppositely charged residues is both necessary and sufficient for high responsiveness and offering design principles for engineering synthetic protein sensors.
This study provides the first comparative neuropathologic and biochemical analysis of PrP deposits in the brain and retina of individuals with GSS-associated F198S mutation, revealing that while both tissues contain seeding-capable aggregates, the retina lacks the constitutive 8 kDa proteolytic fragments found in the brain and exhibits distinct amyloid and glycosylation properties.
Using fallopian tube-derived tumorigenic models, this study demonstrates that progesterone signaling inhibits the migration and adhesion of early-stage high-grade serous ovarian cancer cells while downregulating angiogenesis and stemness markers, though this protective effect is lost in cells harboring additional oncogenic drivers like mutant p53.
This study demonstrates that human umbilical cord mesenchymal stem cell-derived exosomes alleviate neuroinflammation and improve spatial memory in neonatal rats with hypoxic-ischemic brain damage by delivering miRNA-146a-5p to suppress the IRAK/TRAF6 signaling pathway, thereby shifting microglia from a pro-inflammatory M1 to an anti-inflammatory M2 phenotype.
This study demonstrates that human pancreatic islet-derived mesenchymal stromal cells can be rapidly and efficiently reprogrammed into functional, glucose-responsive insulin-producing cells using a sequential viral delivery of ISP (PAX6, ISL1, REST1/2 knockdown) and PMN (PDX1, NGN3, MAFA) transcription factors, establishing them as a promising source for cell-based diabetes therapies.
This study demonstrates that regionally explicit integrated population models for mourning doves in Missouri reveal how biased, non-representative sampling schemes can significantly underestimate survival rates and mislead demographic inferences, highlighting the critical need for practitioners to test and correct for such biases in wildlife monitoring.
The authors present RAcolony, an intelligent, high-throughput platform that integrates Raman spectroscopy with automated imaging to efficiently construct personalized gut microbiome biobanks by significantly reducing redundancy and capturing high-resolution microbial diversity, including novel taxa.
This study validates a live scoring system for aged mice by demonstrating that specific external symptoms, such as abdominal masses and severe neurological issues, strongly predict internal disease burden and tumor presence, thereby providing a standardized framework for objective humane endpoint decisions.
Using superresolution ultrasound localization microscopy, this study reveals that tumor perfusion exhibits significant spatial heterogeneity and temporal instability on an hour-scale, suggesting that short-term fluctuations in microvascular dynamics may critically impact drug delivery efficiency and treatment response variability.