3746 papers
This study integrates transcriptomic data from human diabetic arterial intima and five cultured endothelial cell subtypes to identify a conserved set of downregulated genes that drive endothelial dysfunction through impaired angiogenesis and enhanced inflammation, while also highlighting distinct metabolic and inflammatory responses specific to each context.
This study demonstrates that the optic tectum in *Brevimyrus niger* acts as a central coordinator for active sensing by providing a common drive that temporally precedes and simultaneously activates both electromotor and locomotor outputs.
This study identifies the FfMYB15-FfLAC9 regulatory module in *Flammulina filiformis* as a critical switch that directly links mycelial lignin degradation to fruiting body morphogenesis, offering a promising genetic target for improving the cultivation efficiency of this and related macro-fungi.
This study demonstrates that applying matched genome-background controls to phylogenetic and genomic-context analyses of 1,143 Actinomycetota proteomes significantly refines horizontal gene transfer detection by filtering out false positives caused by broad donor affinity, ultimately identifying 13 robust candidate events that would otherwise be overstated by tree topology and local neighborhood signals alone.
This study demonstrates that contactless laser speckle dynamics can achieve high-accuracy, multi-class decoding of diverse cortical language and auditory states in Wernicke's area with minimal labeled training data, leveraging cross-regional transfer from a self-supervised model trained on inner speech in Broca's area.
This study integrates bulk, single-cell, and spatial transcriptomic analyses to identify and validate a reproducible five-gene mitotic transcriptional programme (BIRC5, CDC20, CENPA, CKS1B, and NUF2) that exhibits significantly higher activity in intestinal-type compared to diffuse-type gastric cancer, providing a prioritized framework for future functional and clinical investigation of Lauren subtype biology.
This study demonstrates that a six-month very low-calorie diet intervention improves cardiometabolic health and gut microbiota diversity in adults with obesity, with distinct sex-specific microbial responses and weight-loss-dependent outcomes that underscore the importance of personalized nutritional strategies.
This study demonstrates that large-scale segmental mutations, including duplications and deletions, serve as a widespread and dynamic mechanism driving presence/absence variation and accessory genome evolution in eukaryotic pangenomes, as evidenced by high mutation rates and repeat-associated breakpoints in *Gephyrocapsa huxleyi* and other species.
This study demonstrates that rapid urbanization in Culiacán, Mexico, drives biotic homogenization by filtering out specialized bat species and favoring hyperdominant generalists, highlighting the critical need to protect peri-urban native vegetation and establish complex ecological corridors to conserve functional diversity.
This paper presents a rapid, four-hour protocol combining mechanical lysis, dual phenol-chloroform-isoamyl alcohol re-extractions, and column purification to successfully overcome mucus-related contamination and yield high-quality RNA and DNA from diverse scyphozoan jellyfish species and life stages, including their symbionts.