🧬 Category

q-bio

1504 papers

🧬 biology

Precipitation frequency and predictability interactively affect lizard life-history traits in absence of water shortage

This study demonstrates that even in the absence of water shortage, the interactive effects of altered precipitation frequency and predictability significantly influence the body size, growth, and survival of the common lizard (*Zootoca vivipara*), thereby affecting population demography and highlighting the need to consider combined climatic factors when predicting climate change impacts.

Rebeca Vicente Moreno, Patrick S. Fitze2026-07-16
🧬 biology

Genomic landscape of inherited retinal diseases for gene therapy and clinical trials in Argentina

This study characterizes the genomic landscape of inherited retinal diseases in Argentina by analyzing 808 molecularly solved patients from the SARA cohort, revealing a complex architecture of recurrent and rare variants across 109 genes that informs patient stratification for clinical trials and gene therapies.

Marcela Ciccioli, Jazmín Martínez, Ezequiel Fernández, Alejandra Antacle, Laura Echandi, Daniel Hidalgo, Mario Saravia (…)2026-07-16
🧬 biology

Pdgfrβ signaling orchestrates meningeal repair via mobilization of arachnoid cells

This study demonstrates that PDGFRβ signaling is essential for orchestrating meningeal repair in zebrafish by mobilizing arachnoid cells from specific sulci to injury sites, a process that subsequently facilitates neurite regrowth and macrophage recruitment, offering potential therapeutic insights for overcoming CNS regeneration barriers in mammals.

Payel Banerjee Chatterjee, Michael Demarque, Axel Benchetrit, Dorian Champelovier, Cynthia Froc, Manon Paul, Hannah Wigg (…)2026-07-16
🧬 biology

Cyclome930: Large-scale replica-exchange dynamics of 930 cyclic peptide reveal thermal stability and critical metal-binding likelihood

This paper introduces Cyclome930, a comprehensive resource of 930 cyclic peptides featuring a novel symmetry-aware alignment algorithm and exhaustive molecular dynamics simulations, which collectively enable the development of machine learning models to predict thermal stability and critical metal-binding likelihood for computational peptide design.

Ratul Chowdhury, Karuna Sajeevan, Hannah Gates, Vaishnavey, Curwen Tan, Riza Danurdoro, Julia Young2026-07-15
🧬 biology

An Accessible Recirculating Organ-on-a-Chip Model of Pregnancy-Associated Breast Cancer Reveals ER Stress-Driven Tumour-Placental Cross-Talk

This study introduces an accessible, recirculating organ-on-a-chip model that mimics pregnancy-associated breast cancer by coupling breast cancer and trophoblast cells to reveal how flow-driven cross-talk induces ER stress, thereby driving tumor invasion and placental dysfunction while offering a platform for therapeutic screening.

Hagar Labouta, Yasmin Abdelkader, Mahmoud Abdelkarim, Paulette Peram, Matthew Kraljevic, Aisha ALSomiry, Rayan Ramadan (…)2026-07-15
🧬 biology

Early heightened processing and later attenuation of social information in autism

This study supports a dynamic model of social information processing in autism, demonstrating that autistic children exhibit early heightened physiological and neural responses to social stimuli followed by a rapid, time-dependent regulatory mechanism that subsequently attenuates the behavioral impact of these representations.

Hui Chen, Jiewei Zheng, Yang Gao, Enze Tang, Zixuan Chen, Yingtao Fu, Yaping Chen, Ruoxi Shi, Mowei Shen, Tengfei Wang2026-07-15