q-bio papers | Gist.Science

Community Genetics Perspectives on Reproductive Decision-Making: Knowledge, Attitudes, and Barriers to Pre-implantation Genetic Testing Acceptance Among Families Affected by Hemoglobinopathies in Oman

This study of 385 Omani families affected by hemoglobinopathies reveals that while awareness of pre-implantation genetic testing (PGT) is low and linked to socioeconomic factors, there is a high willingness to adopt the procedure, highlighting an urgent need for targeted education, counseling, and financial support to bridge the gap between knowledge and reproductive decision-making.

Asma Al Musalhi, Salwa Al Obaidani, Alya Al-Hsani, Nadhira Al-Batashi, Sara Al-Busafi, Manar Al-Maawali, Zainab Al-Hinai (…)2026-09-08

🧬 biology

A therapy-aware multimodal dynamical scaffold reveals residual persistence and relapse-associated escape in pediatric leukemia

This study introduces a therapy-aware multimodal dynamical scaffold that models pediatric leukemia progression as a hybrid process of constrained evolution and punctuated escape, enabling the precise identification of response, residual persistence, and relapse-associated escape states through longitudinal single-cell analysis.

Seung-Hwan Kim2026-09-08

🧬 biology

4D self-supervised learning of cross-dimensional representation enables high-performance denoising of volumetric fluorescence imaging

The paper introduces SDT-4D, a novel 4D self-supervised denoising framework that utilizes a unified transformer architecture and physics-informed uncertainty quantification to achieve state-of-the-art restoration of volumetric time-lapse fluorescence microscopy data without requiring clean training images.

Qionghai Dai, Yixin Li, Tianyu Ma, Qi Zhang, Zhifeng Zhao, Xirou Zhou, Yibo Qu, Xiaoge Wang, Wentao Chen, Zhi Lu, Ziwei (…)2026-09-08

🧬 biology

Impact of non-canonical cysteine on the stability of monoclonal antibody therapeutics: implications for candidate selection

This study challenges the assumption that non-canonical cysteines in monoclonal antibodies inherently compromise stability by demonstrating that a specific HC109 cysteine remains stable due to its buried location in a beta-sheet, leading to a proposed framework for assessing developability risk based on structural context and solvent accessibility rather than automatic elimination.

Rishabh Kaushik, Stella Y. Ren, Carl Kolvenbach, Da Ren2026-09-08

🧬 biology

From teosinte to modern maize: domestication and crop improvement reshape the endophytic microbiome

This study demonstrates that the domestication and improvement of maize from its wild ancestor teosinte significantly reshape the diversity, composition, and functional potential of its endophytic microbiome, with wild relatives and traditional landraces serving as crucial reservoirs of microbial diversity for future sustainable agriculture.

Victoria Galilea Miranda-Luna, Diego Alberto Almaguer-Ruíz, Sofía Rodríguez-Amezquita, Luciana Raggi, Ian MacGregor-Fors (…)2026-09-08

🧬 biology

Ectomycorrhizal fungi as a reservoir of salmon-derived nitrogen in riparian forests

This study demonstrates that ectomycorrhizal fungi act as a significant biological reservoir for marine-derived nitrogen from Pacific salmon, incorporating and retaining this nutrient subsidy in riparian forests even years after direct salmon inputs have ceased.

Anne Y. Polyakov, Erik A. Hobbie, Gordon Holtgrieve, Allen Larocque, Erik Lilleskov, Korena K. Mafune, Kristiina A. Vogt (…)2026-09-08

🧬 biology

A behaviour-centric digital twin framework for animal monitoring: from managed enclosures to landscapes

This paper presents a behavior-centric digital twin framework that integrates a design phase for non-intrusive sensor network planning with a shadow phase for fusing multi-camera detections into a unified 3D world model, successfully validated in wildlife enclosures to transform fragmented monitoring into coverage-aware, world-referenced ecological measurements.

Basavaraj B. Pujar, Keerthikrutha Seetharaman, Pinkal Kumar, Charan Kumar, Ayushman Singh, Smitha D Gnanaolivu, Brij Kis (…)2026-09-08

🧬 biology

Confidence-graded, proteome-wide identification of candidate antimicrobial peptide precursors in the Ghaf tree (Prosopis cineraria) using a preregistered, decoy-calibrated pipeline

Using a preregistered, decoy-calibrated pipeline, this study systematically identifies 18 high-confidence candidate antimicrobial peptide precursors in the Ghaf tree (*Prosopis cineraria*) proteome by applying five convergent evidence criteria and calibrated significance thresholds, while also highlighting critical methodological pitfalls in peptide classification.

Kiran Zahid, Muhammad Riaz2026-09-08

🧬 biology

Mapping Glucagon Resistance Beyond the Pancreas: A Multi-Organ Transcriptomic Characterization of the GCGR–cAMP–PKA–CREB Axis

This in silico systems-biology study maps the multi-organ transcriptomic architecture of the GCGR–cAMP–PKA–CREB axis, revealing that while downstream signaling components are broadly expressed, glucagon receptor availability is highly tissue-restricted, suggesting that receptor scarcity rather than downstream pathway defects may be a primary determinant of glucagon resistance in non-hepatic metabolic organs.

Luis Jesuino de Oliveira Andrade, Gabriela Correia Matos de Oliveira, Raymundo Paraná, Osmário Jorge de Mattos Salles, L (…)2026-09-08

🧬 biology

Visualization of the Osmotic Pressure Concept Through Plasmolysis Observation in Rhoeo discolor: A Physiological Study for Science Education

This study demonstrates that observing plasmolysis in *Rhoeo discolor* epidermal cells under hypertonic conditions provides an effective, visual method for concretizing the abstract concept of osmotic pressure in science education.

Wardah Fitriyani, Thoriqi Firdaus2026-09-08

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