1504 papers
This study reveals that LPS-induced intestinal epithelial damage disrupts MUC2 O-GalNAcylation and adherens junction integrity, but GalNT3 overexpression restores long-chain O-glycans on MUC2, stabilizing E-cadherin and calcium homeostasis to repair the mucosal barrier and mitigate LPS translocation.
This study proposes that Alzheimer's disease lysosomal dysfunction stems not from structural pump failure but from an "energy-starved lysosome" state caused by the disruption of the astrocyte–neuron lactate shuttle, where declining astrocytic lactate export (MCT4) creates a cross-cellular energy deficit that impairs neuronal V-ATPase activity despite preserved pump abundance.
This study identifies the basal-derived extracellular protein SPON2 as a metabolic checkpoint that suppresses mammary morphogenesis and breast cancer by directly binding the glutamine transporter SLC38A1 to restrict nutrient uptake, thereby inhibiting mTORC1 signaling and epithelial expansion.
This study demonstrates that pre-existing immunity to H1N1 influenza enhances antibody responses to seasonal vaccination through germinal center regulation, resulting in superior protection against pandemic H1N1 challenge compared to naive hosts.
This study demonstrates that in male Sprague-Dawley rats fed a high-fructose diet, the combined intervention of High-Intensity Interval Training (HIIT) and Vitamin D3 supplementation is more effective than either treatment alone in reducing liver inflammation, fat accumulation, and fibrosis while improving metabolic markers.
This study identifies two independent classes of allosteric transcription factors, GdnR and a ribbon–helix–helix superfamily protein, that function as guanidine-responsive repressors to regulate bacterial guanidine metabolism, thereby expanding the known regulatory mechanisms and ecological significance of this nitrogen cycle pathway.
Protocatechuic acid (PCA) indirectly alleviates gut inflammation and enhances barrier integrity by remodeling the gut microbiota to increase lithocholic acid (LCA) levels, which then directly binds to and inhibits TAK1 phosphorylation.
This cross-sectional study of 344 children reveals that while fear responses to animals undergo significant developmental recalibration based on perceived danger (e.g., spiders rising in fear rankings with age), disgust responses to parasites and worm-like creatures remain remarkably stable and adult-like from preschool onward, suggesting that animal disgust is more deeply biologically prepared than fear.
This study provides the first evidence that the agile gracile opossum (*Gracilinanus agilis*) in the Brazilian Caatinga exhibits partial semelparity driven by reproductive seasonality rather than rainfall, characterized by high post-reproductive mortality and anticipatory maturation into breeding condition.
This study demonstrates that while open 3D-CT vision-language model features contain decodable EGFR mutation signals in NSCLC, zero-shot prompting fails to access this information due to a geometric misalignment between the text-prompt axis and the discriminative feature direction, a limitation overcome only by supervised probing.