🧬 Category

q-bio

1504 papers

🧬 biology

Prediction of Multidimensional Post-Translational Modification Profiles in Idiopathic Pulmonary Fibrosis Based on Substrate Availability via Non-Targeted Metabolomics

This study utilizes non-targeted metabolomics of idiopathic pulmonary fibrosis (IPF) lung tissue to demonstrate that the dramatic upregulation of specific small-molecule substrates serves as a predictive "building block library" for reconstructing a complex, multidimensional landscape of post-translational modifications, offering a cost-effective alternative to traditional multi-omics approaches for understanding fibrosis mechanisms.

Lulu Han, Hongxia Jia, Mingyang Li, Yanshu Dong, Yan Wang, Sisi Zhang, Jing Li, Ping Li, Qian Cao, Guojun Zhang2026-07-15
🧬 biology

TNFalpha interacting protein 1 as a potential player in neuronal survival, growth and differentiation in the cerebellar cortex

This study characterizes the expression and developmental regulation of TNIP1 in the murine cerebellum, demonstrating its presence in various neuronal and glial cells and its ability to inhibit proliferation, thereby suggesting a novel role for TNIP1 in neuronal survival, growth, and differentiation within the central nervous system.

Esperança Clara Carolina Göttsche, Michael Spoelgen, Sebastian P. Roeser, Karl Schilling, Stephan L. Baader2026-07-15
🧬 biology

TGM2 promotes intracellular persistence of Staphylococcus aureus by aggravating xenophagy dysfunction in bovine mammary epithelial cells

This study demonstrates that TGM2 promotes the intracellular persistence of *Staphylococcus aureus* in bovine mammary epithelial cells by upregulating its expression to aggravate xenophagy dysfunction and impair lysosomal clearance of the pathogen.

Kangjun Liu, LuanYu Ni, Li Fang, Luying Cui, Junsheng Dong, Long Guo, Xia Meng, Jianji Li, Heng Wang2026-07-15
🧬 biology

Novel Paper-Based Electrochemical System for Detection of Anti-Spike Protein Antibodies from SARS-CoV-2

This study presents a novel, disposable paper-based electrochemical biosensor utilizing carbon dots and a liposome–biorecognition complex to sensitively and selectively detect anti-SARS-CoV-2 spike protein antibodies in real nasopharyngeal samples, offering a promising point-of-care solution for monitoring immunity without specialized laboratory facilities.

Rita M. Martins, Adélio M. Mendes, Caglar Elbuken, M. Goreti F. Sales2026-07-15
🧬 biology

Comparative transcriptomic responses to four histone deacetylase inhibitors in feline kidney and astrocyte cell lines

This study utilized RNA sequencing to demonstrate that four histone deacetylase inhibitors elicit distinct, cell type-dependent transcriptomic responses in feline kidney and astrocyte cell lines, providing a foundational resource for developing HDAC inhibitor-based therapies for domestic cats.

Ganma Tanaka, Shizune Nakamura, Rikuto Goto, Akiko Kubota, Naoaki Sakamoto, Akinori Awazu2026-07-15
🧬 biology

Multi-Omics Profiling Identifies Neuroinflammation-Related Genes and Exosomal miRNA as Robust Diagnostic Signatures for Parkinson's Disease

This multi-omics study integrates transcriptomic data and machine learning to identify neuroinflammation-related genes and exosomal miRNAs, establishing a robust five-gene diagnostic signature (PTGDS, RTN3, MAG, PROK2, and CNTNAP2) and elucidating monocyte-driven neuroinflammatory mechanisms in Parkinson's disease.

Dongdong WU, Xinxin MA, Huimin CHEN, Huijing Liu, Jing HE2026-07-15
🧬 biology

Bayesian Sparse Mixed-Response Species Distribution Models with Spatial Dependence

This paper introduces a Bayesian sparse mixed-response species distribution model that integrates shared environmental feature selection, Polya-Gamma augmentation, and low-rank spatial dependence to effectively handle continuous, binary, and count ecological data while outperforming response-wise regressions in recovering sparse structures and improving predictive accuracy.

Hsin-Hsiung Huang, Osamu Komori2026-07-15
🧬 biology

Scalable penalized regression boosts accuracy and computational efficiency for single- and cross-ancestry polygenic prediction

This paper introduces a scalable penalized regression framework comprising Spike-and-Slab Lassosum (SSL) and its prior-informed extension (pSSL), which significantly enhance both the predictive accuracy and computational efficiency of single- and cross-ancestry polygenic scores while addressing Eurocentric biases in genomic studies.

Chaolong Wang, Hongji Wu, Ziwei Zhu, Haonan Kang, lanbo ding, Guoshuang Feng, Tangchun Wu, Shanshan Cheng2026-07-15
🧬 biology

Overexpression of Glutamate Decarboxylase Gene SiGAD1 generates high levels of γ-aminobutyric acid (GABA) in foxtail millet grains

This study demonstrates that overexpressing the foxtail millet gene SiGAD1, particularly its full-length variant, significantly enhances glutamate decarboxylase activity to substantially increase GABA accumulation and reduce glutamate levels in grains, offering a promising strategy for breeding high-GABA millet varieties.

Rui Zhao, Yang Liu, Ke-Jin Liu, Mao-Sheng Jin, Jia-Xuan Hu, He-Jing Wu, Xiangyang Yuan, Xiaoqian Chu, Jia-Gang Wang2026-07-15
🧬 biology

Differential genetic resistance identified in Parastagonospora nodorum and Pyrenophora tritici-repentis-wheat pathosystems

This study identifies distinct genetic resistance mechanisms in wheat against the necrotrophic pathogens *Parastagonospora nodorum* and *Pyrenophora tritici-repentis*, revealing a major QTL for tan spot resistance on chromosome 1B, multiple minor QTLs for Septoria nodorum blotch, and differential cytological defense responses that highlight the unique underlying strategies for combating each disease.

Huyen TT Phan, Eiko Furuki, Fiona Kamphuis, Kasia Rybak, Leon Lenzo, Catherine F. Cupitt, Kalai Marathamuthu, Pao Theen (…)2026-07-15