🧬 Category

q-bio

3746 papers

🧬 biology

Gastric cancer-sarcopenia axis driven by tumor-derived GDF15, MIF and MDK signaling: evidence from Mendelian randomization, single-cell transcriptomics and survival analysis

This study integrates Mendelian randomization, single-cell transcriptomics, and survival analysis to establish a unidirectional causal link between gastric cancer and sarcopenia, identifying a tumor-derived GDF15, MIF, and MDK signaling axis as the key driver of muscle wasting and a potential target for clinical intervention.

Qihao Wu, Jun Wang, Wujin Chen2026-09-08
🧬 biology

Disequilibrium Between Chloroplast Proton Motive Force and ATP Levels in Arabidopsis Thaliana

This study reveals that in Arabidopsis thaliana, stromal ATP levels remain stable despite a significantly reduced chloroplast proton motive force, challenging the traditional view of a tight coupling between pmf and ATP production and suggesting that energy balance is maintained through flexible regulation of ATP synthesis and consumption rather than solely by PGR5-dependent cyclic electron transfer.

Abdul Samad, Ayatullah Soomro, Tayyaba Zulfiqar, Muhammad Haris, Abdul Sami, Zohaib khan, Balqees naz2026-09-08
🧬 biology

Gene-environment interactions for plasma proteins improve disease prediction

This study constructs a comprehensive atlas of gene-environment interactions for plasma proteins by identifying novel variance quantitative trait loci and their interactions with diverse exposures, demonstrating that incorporating these interactions significantly improves the prediction accuracy of 46 incident diseases.

Chunshui Yu, Ying Wang, Sijia Wang, Yao wang, Mengge Liu, Jinbo Qi, Jia Wang, Jiayuan Xu, Hui Xue, Nana Liu, Hao Ding, F (…)2026-09-08
🧬 biology

The Biological Characteristics and Metabolomics Response Patterns of Zygosaccharomyces rouxii strains under Salt Stress

This study demonstrates that serial passaging of *Zygosaccharomyces rouxii* under increasing salt stress enhances its thermal and pH tolerance while inducing distinct metabolic reprogramming, where intermediate adaptation (G10) prioritizes active transport and ATP generation, whereas extreme adaptation (G15) shifts focus toward redox balance and enzymatic protection to survive severe hyperosmotic conditions.

Qinghua Zheng, Hongguang Zhu, Hui Guo, Gaojie Fu, Haixin Sun2026-09-08
🧬 biology

Antinociceptive and anti-inflammatory mechanisms of fenugreek (Trigonella foenum- graecum L.) fractions in a murine model: involvement of the L-arginine/nitric oxide pathway and pro-inflammatory cytokine suppression

This study demonstrates that a flavonoid-rich fraction of fenugreek seeds exerts significant antinociceptive and anti-inflammatory effects in mice by suppressing the L-arginine/nitric oxide pathway and pro-inflammatory cytokines without involving the opioid system or causing motor impairment.

Faegheh Farhadi, Fariba Sharififar, Arefeh Mohammadi, Atefeh Hajializadeh, Moazamehosadat Razavinasab, Majid Jafari-Sabe (…)2026-09-07
🧬 biology

Species or subspecies? Integrative taxonomy clarifies the status of a Mexican Athis Hübner, [1819] (Lepidoptera: Castniidae)

This study employs an integrative taxonomic approach combining morphology, geometric morphometrics, molecular data, distribution, and host plant analysis to reclassify populations of the Mexican *Athis hechtiae* group, ultimately elevating the distinct *Athis gonzalezi* from subspecies to species status.

José de Jesús García-Díaz, Rosa Ana Sánchez-Guillén, César Espinoza-Campuzano, Alejandro Espinosa de los Monteros, André (…)2026-09-07
🧬 biology

House mice (Mus musculus domesticus) demonstrate prosocial behaviour only in the absence of food rewards

This study on wild-derived house mice reveals that their prosocial behavior is highly context-dependent, as they prioritized self-interest in a choice test but demonstrated rapid helping behavior in a release paradigm, underscoring the necessity of using multiple experimental designs to accurately assess social traits.

Tamara Isabelle Sorg, Anja Guenther, Peter M. Kappeler, Claudia Fichtel2026-09-07
🧬 biology

Ecological conditions effect on the Anatomical characters of Myrtus communis in Kasnazan, Shameran and Erbil Center in Kurdistan Region of Iraq

This study utilizes the paraffin method to characterize and compare the anatomical features of *Myrtus communis* stems, leaves, and fruits from three distinct ecological sites in the Kurdistan Region of Iraq, revealing specific tissue structures such as peridermis, various trichomes, oil cavities, anomocytic stomata, and reticulate venation.

chnar Fathulla, Rasty Muhammad, Serwan Al-dabbagh2026-09-07
🧬 biology

Kruppel-like-factors 4, 9 and 13 - modeling and modulating at the master regulatory borders of cell fate and cell death decisions in adrenocortical carcinoma

This study elucidates a novel transcriptional axis in adrenocortical carcinoma where KLF9 and KLF13 counteract SF-1 to modulate steroidogenesis, while KLF4 regulates the DNA damage response to influence cell survival, collectively offering new targets for therapeutic intervention.

Constanze Hantel, Edlira Luca, Igor Shapiro, Stefan Bornstein, Felix Beuschlein, Sandra Sigala, Alfredo Berruti, Nicole (…)2026-09-07
🧬 biology

Short-term Bacillus clausii administration remodels the peripheral T-cell receptor repertoire through convergent CDR3 sequence architectures

Short-term administration of *Bacillus clausii* induces selective quantitative remodeling of the peripheral T-cell receptor repertoire by expanding pre-existing clonotypes and fostering convergent CDR3 sequence architectures, thereby fine-tuning adaptive immunity within a preserved structural framework rather than causing wholesale restructuring.

Angela Mauriello, Ana Mendizabal-Sasieta, Juan Luis Melero, Marta Soto, Marta Grzelak, Mariana Capelli, Holger Heyn, Mar (…)2026-09-07