🧬 biology

Early insights into viability of Ebola monoclonal antibodies for the 2026 Bundibugyo virus disease outbreak

Genomic and structural analyses of the 2026 Bundibugyo virus outbreak suggest that while the mAb114 therapy may be compromised by specific mutations, the MBP134 cocktail remains a promising broadly protective option and the Inmazeb trimeric cocktail retains efficacy through synergistic binding, highlighting the critical need for urgent experimental validation.

Daudi Jjingo, Kevin Cissy Nabukeera, Gradi Luakanda-Ndelemo, Syrus Semawule, Pascal Adroba Tandele, Andrew Walakira, Adr (…)2026-07-15
🧬 biology

Automated Histological Assessment of Parkinson’s Disease Models via Integrated Dopaminergic Neuron Segmentation and Phenotypic Quantification

This paper introduces SegDAFormer, a novel dual-head transformer architecture that unifies dopaminergic neuron segmentation and Tyrosine Hydroxylase (TH) phenotypic quantification in Parkinson's disease models, significantly outperforming existing methods by providing a scalable, biologically interpretable framework for automated histological assessment.

Prema Arokia Mary G, Jayavadivel Ravi, Hema M S, M Nageswara Guptha2026-07-15
🧬 biology

More rapid influenza virus elimination on baloxavir versus oseltamivir can be explained by drug mechanism

A data-validated mathematical model demonstrates that baloxavir achieves more rapid influenza viral load elimination than oseltamivir by inhibiting viral replication earlier in the cycle, suggesting that viral load reduction kinetics are drug-class specific and may require independent validation as clinical surrogate endpoints.

Katherine Owens, Angela Tower, Elissa Schwartz, Elizabeth Duke, Joshua Schiffer, Shadisadat Esmaeili2026-07-15
🧬 biology

Three new species of Isospora Schneider, 1881 (Apicomplexa: Eimeriidae) infecting the song sparrow Melospiza melodia Wilson, 1810 (Aves: Passeriformes: Passerellidae) in Toluca Valley, Mexico

This study describes three new species of *Isospora* (*I. cantoris*, *I. melodiae*, and *I. villai*) infecting the song sparrow (*Melospiza melodia*) in the Toluca Valley, Mexico, based on the morphological characteristics of their sporulated oöcysts.

Edgardo Soriano-Vargas, Karla Patricia Galindo-Sánchez, Uriel Marín-Ávila, Marco Antonio García-Albarrán, Celene Salgado (…)2026-07-15
🧬 biology

Memory-Delay Stability Switching and Ecological Thresholds in a Dimensionally Balanced Fractional-Order Predator-Prey Model

This paper presents a dimensionally consistent fractional-order delayed predator-prey model incorporating fear, refuge, Holling type-III response, and nonlinear harvesting to analyze how fractional memory and time delay jointly govern stability switching and ecological thresholds, validated through comprehensive analytical and numerical investigations.

Suman Mondal, Tapan Kumar Kar2026-07-15
🧬 biology

APOE3 Christchurch is associated with sphingolipids recycling and glial lipid remodeling in autosomal dominant Alzheimer’s disease

This study reveals that the protective APOE3 Christchurch variant mitigates lipid-driven neuroinflammation in autosomal dominant Alzheimer's disease by promoting sphingolipid recycling and glial lipid remodeling while suppressing de novo cholesterol biosynthesis.

Iván Daniel Salomón-Cruz, Sara Camila Agudelo-Castrillon, Juan Pablo Barbosa-Carvajal, Laura Alejandra Lozano-Trujillo (…)2026-07-15