A Continuous Constraint-by-Timing Landscape in Autism Common-Variant Risk Genes Without Identifiable Discrete Subtypes

This study analyzes autism common-variant risk genes using five continuous biological features and demonstrates that they form a continuous, unevenly dense landscape defined by evolutionary constraint and developmental timing, rather than distinct discrete subtypes that remain stable across varying analytic thresholds.

Original authors: Noah Berley, Stephen Becker, Michael Stallings