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Effect of Dexamethasone and diclofenac in combination with ceftriaxone on the virulence activities of different Pseudomonas aeruginosa clinical isolates

This study demonstrates that while many *Pseudomonas aeruginosa* clinical isolates exhibit high multidrug and extensively drug resistance, the combination of diclofenac and dexamethasone with ceftriaxone reduces bacterial growth and downregulates virulence genes (algD, plch, toxA), with green silver nanoparticles showing the most potent inhibitory effect on both growth and virulence factor expression.

Original authors: Mohamed Mohamed Adel El-Sokkary, Adham Mohamed Ramadan, Islam El-Said Ibrahim, Ahmed Alaa Hussein Azzam, Islam Fouad Abd-Elrahman, Ahmed Ali Abd-Elmageed

Published 2026-10-26
📖 1 min read☕ Coffee break read

Original authors: Mohamed Mohamed Adel El-Sokkary, Adham Mohamed Ramadan, Islam El-Said Ibrahim, Ahmed Alaa Hussein Azzam, Islam Fouad Abd-Elrahman, Ahmed Ali Abd-Elmageed

Original paper licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). ⚕️ This is an AI-generated explanation of a preprint that has not been peer-reviewed. It is not medical advice. Do not make health decisions based on this content. Read full disclaimer

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