🧬 Category

q-bio

4605 papers

🧬 biology

Hierarchically supervised computational pathology stratifies HER2 categories and ERBB2 amplification risk from routine H&E slides in breast cancer

The paper introduces CHERISH, a hierarchically supervised computational pathology framework that leverages routine H&E slides to accurately stratify HER2 categories and predict ERBB2 amplification risk by embedding clinical testing logic into its architecture, thereby overcoming the limitations of conventional models and reducing the need for resource-intensive confirmatory testing.

Xiaohua Zeng, Yansong Ba, Long Wang, Xiaomin Xiong, Xin Zhou, Qingming Jiang, Sihao Liu, Shanqi Li, Zhigang Pei, Tao Zha (…)2026-06-29
🧬 biology

Causal Responsibility Based Explainable AI for Vibrational Spectroscopy Applied to Cancer Diagnostics

This paper introduces Spec-ReX, a causal responsibility-based Explainable AI method for vibrational spectroscopy in cancer diagnostics, and rigorously validates its performance against other XAI techniques across in silico, in vitro, and ex vivo datasets to address the critical need for transparent clinical decision-making.

Nathan Blake, David Kelly, Sarah Kapllani-Mucaj, Rong Wang, Geraint Thomas, Hana Chockler2026-06-29
🧬 biology

The Artemis I mission reshaped seed amino acid composition and post-flight plant growth in a genotype-dependent manner

The Artemis I mission induced genotype-dependent changes in seed amino acid profiles and post-flight growth in *Arabidopsis thaliana*, revealing that branched-chain amino acid metabolism is a critical factor influencing plant responses to deep-space exposure.

Joanne E Thomson, Evan Angelos, Ramona Gaza, Dinah Dimapilis, Ye Zhang, Kamber Scott, James O’Keefe, Federica Brandizzi2026-06-29
🧬 biology

Genetic dissection of dynamic leaf area index variation in maize using UAV-based phenotyping and time-series genome-wide association studies

This study establishes a robust framework integrating UAV-based multispectral phenotyping and time-series genome-wide association studies to identify dynamic genetic loci and the candidate gene *Zm00001d048615* that regulate maize leaf area index, offering valuable targets for improving canopy architecture and yield.

Xuyang Wang, Jiaojiao Ren, Penghao Wu2026-06-29
🧬 biology

Sustained transcription and permissive chromatin in murine spermiogenesis

This study challenges the long-held view that spermiogenesis involves global transcriptional silencing by demonstrating that the haploid genome remains transcriptionally active and dynamically organized throughout this phase, necessitating a redefinition of late spermatid differentiation as a period of transcriptional specialization rather than shutdown.

Bing Li, Yimin Lao, Jingdong Xue, Yixuan Pan, Mengyuan Peng, Qi Zhang, Ming Yu, Lijuan He, Meiyang Liu, Mingqian Hu, Yuq (…)2026-06-29
🧬 biology

Daily symptom reports enable four-phase menstrual cycle tracking without wearables: Implications for equitable digital health

This study demonstrates that a hybrid machine learning model utilizing daily self-reported symptom variability can accurately classify four menstrual cycle phases without wearable sensors, offering a scalable and equitable solution for global reproductive health monitoring.

Bernhard Specht, Mohammad EL-Khozondar, Samaher Garbaya, Reinhard Schneider, Djamel Khadraoui, Zied Tayeb2026-06-29
🧬 biology

Efficient exploration of conformational ensembles via protein interaction-informed deep learning

This paper introduces DynoM, a generative deep learning framework trained on protein complex interactions that significantly outperforms existing monomer-only models in predicting accurate conformational ensembles and suppressing structural hallucinations by leveraging the long-range physical constraints inherent in complex data.

Zilin Ren, Duo Liu, Qianyi Jia, Qiantong Jin, Yubin Liu, Chan Liu, Zhixiang Sui, Luyao Han, Yixiang Zhang, Xin Yang, Pin (…)2026-06-29
🧬 biology

Delayed downstream detection and persistence of fish eDNA in a low-flow stream: a field observation

This study provides field evidence that in low-flow streams, fish eDNA signals exhibit a delayed downstream appearance and persist for a period after the source organism is removed, highlighting the need to account for transport dynamics and temporal persistence when interpreting eDNA data in lotic ecosystems.

KeonHee Kim, KyuJin Kim, JongWook Kim, JaeGoo Kim, Ji-Woong Choi, Min-Ho Jang2026-06-29