4605 papers
This study constructed and validated a robust machine learning-based prognostic model using 32 tumor microenvironment-related genes to predict biochemical recurrence in prostate cancer, revealing distinct immune landscapes and potential therapeutic sensitivities for risk-stratified patient management.
This study demonstrates that microsaccade dynamics serve as a non-volitional physiological biomarker for expertise in chest radiography, as increased microsaccade production during nodule fixation correlates with successful detection and distinguishes higher-accuracy readers from less experienced ones.
This study identified three triaptosis-related prognostic genes (BNIP3L, KLHDC1, and PRDX3) in breast cancer through bioinformatic analysis and RT-qPCR validation, establishing a predictive nomogram that links these genes to oxidative phosphorylation pathways, immune infiltration, and potential therapeutic targets.
This study presents the first complete mitogenomic characterization of the Mottled Wood-owl (*Strix ocellata*), revealing its unique gene rearrangement patterns, strong purifying selection, and basal phylogenetic position within the genus *Strix*, while highlighting the critical need for expanded genomic sampling to fully resolve the evolutionary history of Strigiformes.
This study utilizes scanning electron microscopy and phylogenetic analyses of 20 Pakistani Boraginaceae species to demonstrate that while diverse seed morphological and micromorphological traits are effective for species-level identification, their evolutionary lability and high homoplasy limit their utility for higher taxonomic classification.
This study of 451 Egyptian children reveals that *Giardia duodenalis* transmission is predominantly anthroponotic, with Assemblage A exhibiting a clonal, human-adapted structure and Assemblage B showing greater genetic diversity, collectively indicating that public health interventions should prioritize interrupting human-to-human spread among young children.
This study integrates single-cell and transcriptome analyses to reveal that microglial phagocytic reprogramming, driven by the upregulation of Axl, evolves through distinct temporal phases during neuropathic pain progression and serves as a critical mechanism for sustaining chronic pain, suggesting Axl inhibition as a potential therapeutic strategy.
This study characterizes the distinct rhizosphere microbial community structure of *Taraxacum koksaghyz* in Xinjiang's saline-alkaline soils, revealing that while bacterial diversity decreases with increasing salinity, specific halotolerant bacteria and stress-tolerant fungi are enriched in response to varying ion compositions and nutrient availability, offering insights for improving crop yields in such environments.
This study demonstrates that developmental heat stress in male *Aedes aegypti* mosquitoes impairs their reproductive fitness and significantly disrupts their ability to induce normal female post-mating responses, leading to increased remating and reduced sperm storage, with potential implications for vector control programs under warming environmental conditions.
This study utilizes single-cell ATAC-seq combined with genetic barcoding to link diverse functional manipulations of CAR T cells to their specific chromatin signatures, revealing how cytokine concentrations and CAR design influence transcription factor activities and differentiation programs to enhance therapeutic efficacy.