4605 papers
This study demonstrates that patient-derived glioblastoma organoids exhibit distinct, patient-specific phenotypic responses to HDAC inhibition, highlighting their utility as translational platforms for evaluating individualized epigenetic therapies.
This large-scale integrative genetic analysis reveals significant shared genetic architecture and causal links between five autoimmune diseases and venous thromboembolism, identifying key immunothrombotic loci, mediators like IL6R, and potential therapeutic targets for risk stratification and drug repurposing.
This study reveals that LGR6 ameliorates diabetic adipose dysfunction by inhibiting ferroptosis, as its downregulation in Type 2 diabetes exacerbates adipocyte hypertrophy and inflammation through iron-dependent cell death, while its restoration rescues adipogenic capacity and mitigates metabolic disorders.
This systematic review synthesizes evidence on musculotendinous unit stiffness in elite sprinters, revealing mixed findings regarding specific mechanical traits and highlighting that while measurement reliability is generally acceptable, the precise mechanical profile that optimizes sprint performance remains unclear.
This study of 4,736 ABCD cohort participants reveals that racialized heteroscedasticity, characterized by consistently higher variance in neuroimaging and behavioral data for Black participants, systematically induces disparities in prediction error and model reliability even when mean differences are absent, highlighting variance structure as a critical determinant of model generalizability across diverse populations.
This study utilizes large-scale genomic analyses to identify substantial genetic overlap and shared susceptibility loci between high-grade serous ovarian cancer and female reproductive timing traits, revealing convergent biological mechanisms in immune regulation and chromatin organization that extend the incessant ovulation hypothesis into a genetic framework.
This systematic review of 32 human studies indicates that while gut microbiome dysbiosis is consistently associated with depression and anxiety and that microbiome-targeted therapies show modest symptomatic benefits, causal conclusions remain tentative and future research requires more rigorous, standardized methodologies to establish definitive causal links.
This study demonstrates that Hepatitis B virus integration, specifically at the chrX:111,009,033 site within the PAK3 gene, upregulates PAK3 expression to induce epithelial-mesenchymal transition and enhance metastatic potential in HepG2.2.15 cells, thereby promoting hepatocarcinogenesis through the activation of JAK/STAT and MAPK signaling pathways.
This cross-sectional study of 65 young adults reveals that sports participation is the primary predictor of superior dynamic balance and reduced center-of-pressure sway, whereas visual reliance and inter-limb symmetry showed no significant association with performance.
This study utilized in silico drug repurposing and rational hybrid design to identify and develop potent falcipain inhibitors for malaria treatment, demonstrating that combining high-affinity non-antimalarial compounds like Telithromycin with existing antimalarials yields superior hybrid candidates, particularly TELI-ATOVA, which warrants further experimental validation.