🧬 Category

q-bio

4605 papers

🧬 biology

The Effect of Microgravity on the Human Voice, Phonation- A Single Case Study

This single-case study demonstrates that exposure to microgravity induces significant, subclinical alterations in human phonation—specifically marked reductions in vocal stability and contact quotient alongside increased jitter—likely caused by systemic fluid shifts and altered respiratory mechanics, thereby highlighting the need for continued monitoring and the potential use of vocal metrics as a health indicator for astronauts.

Adél Bihari, Ádám Schlégl, Tamás Perlaki, Petra Hermann, Zsolt Garami, Eszter Dabasi, Tamás Hacki2026-06-28
🧬 biology

A stabilized abdominal imaging platform for intravital interrogation of preclinical omental metastatic niche models

This paper presents a mechanically stabilized abdominal imaging platform that enables high-resolution, longitudinal intravital visualization of the omental metastatic niche in live mice by isolating the tissue from respiratory motion while preserving physiological dynamics, thereby overcoming the limitations of current methodologies for studying peritoneal cancer progression and immunotherapy responses.

Román García-Fuentes, Nicolás López de Aguileta, Beatrice Pinci, Daniel Moreno-Luqui, Yufei Zheng, Ainara Salgado-Pascua (…)2026-06-28
🧬 biology

Immuno-PET imaging of CD38 expression in multiple myeloma using a 64Cu-labeled nanobody

This study demonstrates that a 64Cu-labeled anti-CD38 nanobody (WF121) enables specific, high-contrast immuno-PET imaging of CD38 expression in multiple myeloma xenografts, validating its potential as a non-invasive companion diagnostic for guiding targeted therapies.

Sébastien GOUARD, Tacien Petithomme, Patricia Le Saëc, Vincent Nguyen, Judith Fresquet, Séverine Marionneau-Lambot, Clém (…)2026-06-28
🧬 biology

Comparative analysis of the severity of spatial memory deficits under hormonal environmental and pharmacological interactions in the Morris Water Maze

This study demonstrates that while chronic stress, aluminum chloride exposure, and tramadol administration all impair spatial memory in animal models, the combination of hormonal loss (ovariectomy) and environmental toxicity (aluminum chloride) induces the most profound hippocampal dysfunction, whereas stress accelerates memory loss but shows a complex kinetic response.

Jospin Chirac NOUBOUWO, Cécile Evodie TONPOUWO2026-06-28
🧬 biology

Bacteroides intestinalis AM-1 rewires glutathione and bile acid metabolism to restore mitochondrial homeostasis and ameliorate necro-apoptosis in acute liver failure

This study demonstrates that the probiotic *Bacteroides intestinalis* AM-1 ameliorates acute liver failure by rewiring glutathione and bile acid metabolism to restore mitochondrial homeostasis and suppress necro-apoptosis, thereby significantly reducing liver injury and mortality.

Sushmita pandey, Neha Sharma, Nupur Sharma, Sadam Bhat, Vipul sharma, Manish Kushwaha, Anil Kumar, Yash Magar, Abhishak (…)2026-06-28
🧬 biology

Mitochondrial Macro-Haplogroup U and Multiple Sclerosis Risk in Arab and Near Eastern Populations: A Pedigree-Anchored Systematic Review and Meta-Analysis

This pedigree-anchored systematic review and meta-analysis demonstrates a robust, directionally consistent association between mitochondrial macro-haplogroup U and Multiple Sclerosis risk across Arab, Iranian, and European populations, yielding a pooled odds ratio of 1.91 despite the limited power of the initial Arab discovery cohort.

Ibrahim Ibrahim Shuaibu2026-06-28
🧬 biology

Differential placental immune mediators in pregnant women with preeclampsia infected or not with SARS-CoV-2

This study investigates the differential placental immune mediators in pregnant women with preeclampsia, with or without SARS-CoV-2 infection, revealing that specific alterations in immune molecule expression at the maternal-fetal interface may explain why preeclamptic women infected with COVID-19 exhibit a less severe clinical presentation compared to those with COVID-19 alone.

Neila Caroline Henrique Silva, Camila Rodrigues Melo Barbosa, Débora Rayanne Arruda, Nathália Lorena Zeferino Araujo, Ma (…)2026-06-28
🧬 biology

TRIM36 Catalyzes K63-Linked Ubiquitination of TAK1 to Drive Septic Inflammation

This study identifies TRIM36 as a critical positive regulator of septic inflammation that drives TLR4 signaling by catalyzing K63-linked ubiquitination of TAK1, thereby promoting NF-κB activation and cytokine production, which suggests its potential as a therapeutic target for sepsis.

Shijie Song, Dingnai Nie, Zulaya Abudureyimu, Yijin Kuang, Wen Li, Xiaodan Yang, Qiao Ling, Junli Sheng, Huiru He, Xiaol (…)2026-06-28
🧬 biology

Technical replicates and multiple sequencing approaches reveal weak and inconsistent microbiome signals in tumour and blood samples

This study demonstrates that microbiome signals in low-biomass lung cancer tumor, adjacent tissue, and blood samples are weak, inconsistent, and indistinguishable from contamination, highlighting the critical need for rigorous validation methods like technical replicates and absolute quantification to ensure data reliability.

Vanessa DeClercq, André M Comeau, Alessi Kwawukume, Rowan Murphy, Nidhi R Parmar, Dylan P Quinn, Robyn Wright, Alison Wa (…)2026-06-28