4608 papers
This study identifies TRIM36 as a critical positive regulator of septic inflammation that drives TLR4 signaling by catalyzing K63-linked ubiquitination of TAK1, thereby promoting NF-κB activation and cytokine production, which suggests its potential as a therapeutic target for sepsis.
This study demonstrates that microbiome signals in low-biomass lung cancer tumor, adjacent tissue, and blood samples are weak, inconsistent, and indistinguishable from contamination, highlighting the critical need for rigorous validation methods like technical replicates and absolute quantification to ensure data reliability.
This study demonstrates that hemiparkinsonian rats exhibit impaired multimodal sensorimotor gating and heightened sensitivity to 5-HT2 receptor-mediated hallucination-like behaviors, suggesting that upregulated 5-HT2 receptors contribute significantly to psychosis-associated symptoms in Parkinson's disease.
This study developed a machine learning-based prognostic model using 11 immunogenic cell death-related genes to effectively stratify neuroblastoma patients by risk, revealing distinct differences in immune microenvironment, signaling pathways, and drug sensitivity between high- and low-risk groups.
This study demonstrates that river freezing in a North Chinese mountain stream significantly alters environmental conditions and macroinvertebrate community structure by shifting diversity patterns from being jointly shaped by water chemistry and spatial distance to being dominated by specific abiotic filters and dispersal limitation, respectively.
While low water flow enhances pigmentation and lipid reserves in newly settled *Acropora digitifera* corals, it significantly increases early mortality risk compared to moderate and high flow regimes, demonstrating that optimal conditions for physiological development do not necessarily maximize survival.
This study validates [3H]5-MOP as a novel, highly selective, and high-affinity radioligand for the CSF1R receptor that outperforms existing tools like [3H]CPPC by lacking cross-reactivity with other brain kinases, thereby enabling accurate neuroimaging of neuroinflammation and drug occupancy.
This study reveals that mucosa-associated invariant T (MAIT) cells are enriched and highly functional within the follicular fluid of patients with polycystic ovary syndrome (PCOS), where they exhibit increased immunoreactivity and cytokine secretion that likely contribute to the ovarian inflammatory environment.
This in vitro split-sample study demonstrates that photobiomodulation significantly enhances the cellular distribution, fibrin architecture, and growth factor release of platelet-rich fibrin in a wavelength-dependent manner, with 940 nm optimizing structural integrity while 660 nm and 810 nm preferentially boosting specific growth factor responses.
This study systematically characterizes the 70-member WRKY gene family in Hass avocado, revealing its evolutionary expansion via segmental duplication and identifying specific candidate genes that play crucial roles in regulating differential defense responses against insect herbivory and pathogen infections.