4656 papers
This study demonstrates that high-fat diet-induced MAFLD disrupts sleep architecture in mice by triggering hippocampal neuroinflammation and a specific bifurcated dysregulation of the IRS-1/Akt/mTOR signaling pathway, establishing a novel liver–hippocampus–sleep axis.
This paper presents a unified framework that integrates a Ribo-seq-informed transcriptomic language model with standard mass spectrometry workflows to systematically detect microproteins from non-canonical open reading frames without requiring specialized experimental protocols.
This study successfully bred a high-yield *Aspergillus niger* mutant via mutagenesis and fermentation optimization to produce a purified low-temperature lipase with superior catalytic activity at 15°C, offering a cost-effective solution for energy-efficient industrial applications.
This study demonstrates that specific synthetic pheromonal blends derived from male black rat preputial gland extracts can elicit distinct, sex-dependent attractive or repellent behaviors, with Blend 31 (AUDTH) showing the most consistent attractant potential and Blends 19 and 24 serving as effective repellents for future rodent management strategies.
The paper introduces fishROI, a specialized, semi-automated FIJI2 plugin that leverages machine learning-based segmentation to overcome existing limitations in analyzing and visualizing the unique muscle morphometry and hyperplastic growth dynamics of teleosts.
This study demonstrates that fecal microbiota transplantation alleviates asthmatic airway inflammation by modulating the microbiota–gut–lung axis through the TLRs-IL-33 signaling pathway, offering a potential microecological therapeutic strategy for asthma.
This multi-ethnic analysis of the 1000 Genomes Project demonstrates that sex-stratified polygenic risk scores for cardiovascular disease reveal significant sex-specific genetic architectures, with females exhibiting higher genetic risk scores than males across diverse ancestral groups, thereby challenging current sex-blind assessment paradigms.
This study reveals that activated mucosal-associated invariant T (MAIT) cells, which expand in the periphery of pediatric metabolic dysfunction-associated steatotic liver disease (MASLD) patients via MR1-dependent and IL12/IL18-dependent pathways and migrate to the liver through the CXCR6-CXCL16 axis, play a protective role by reducing hepatic lipid accumulation, suggesting their potential as biomarkers and therapeutic targets.
This study demonstrates that patient-derived glioblastoma organoids exhibit distinct, patient-specific phenotypic responses to HDAC inhibition, highlighting their utility as translational platforms for evaluating individualized epigenetic therapies.
This large-scale integrative genetic analysis reveals significant shared genetic architecture and causal links between five autoimmune diseases and venous thromboembolism, identifying key immunothrombotic loci, mediators like IL6R, and potential therapeutic targets for risk stratification and drug repurposing.