🧬 Category

q-bio

4656 papers

🧬 biology

Mucosal-Associated Invariant T Cells Confer Protection in Pediatric Metabolic dysfunction-Associated Steatotic Liver Disease

This study reveals that activated mucosal-associated invariant T (MAIT) cells, which expand in the periphery of pediatric metabolic dysfunction-associated steatotic liver disease (MASLD) patients via MR1-dependent and IL12/IL18-dependent pathways and migrate to the liver through the CXCR6-CXCL16 axis, play a protective role by reducing hepatic lipid accumulation, suggesting their potential as biomarkers and therapeutic targets.

Xingyun Wang, Shumin Zhan, Ke Huang, Guanping Dong, Xuelian Zhou, Qiannan Ren, Shan Wang, Senjie Wang, Xiaochun Chen, Ti (…)2026-06-28
🧬 biology

Shared Genetic Architecture and Causal Relationships between Autoimmune Diseases and Venous Thromboembolism: A Large- Scale Cross-Trait Integrative Analysis

This large-scale integrative genetic analysis reveals significant shared genetic architecture and causal links between five autoimmune diseases and venous thromboembolism, identifying key immunothrombotic loci, mediators like IL6R, and potential therapeutic targets for risk stratification and drug repurposing.

Yichen Long, Yang Ou, Guangxiang Huang, Xin Tan, Shengyan Zhao, Lang Min, Chunyan Sun, Zeyu Luo, Hui Pan2026-06-28
🧬 biology

Does the Evidence Support an Optimal Mechanical Profile? A Systematic Review of Musculotendinous Stiffness in Elite Sprinters

This systematic review synthesizes evidence on musculotendinous unit stiffness in elite sprinters, revealing mixed findings regarding specific mechanical traits and highlighting that while measurement reliability is generally acceptable, the precise mechanical profile that optimizes sprint performance remains unclear.

David Sturrock, John B. Cronin, Dustin J. Oranchuk2026-06-28
🧬 biology

Racialized Heteroscedasticity in Neuroimaging Features, Behavior Measures, and Neuroimaging-Based Predictive Models

This study of 4,736 ABCD cohort participants reveals that racialized heteroscedasticity, characterized by consistently higher variance in neuroimaging and behavioral data for Black participants, systematically induces disparities in prediction error and model reliability even when mean differences are absent, highlighting variance structure as a critical determinant of model generalizability across diverse populations.

Christopher Fields, Matthew Rosenblatt, Joseph Aina, Jannat Thind, Annie Harper, Chyrell Bellamy, Xin Zhou, Alexandra Po (…)2026-06-28
🧬 biology

Pleiotropic genetic links between high-grade serous ovarian cancer and female reproductive timing traits

This study utilizes large-scale genomic analyses to identify substantial genetic overlap and shared susceptibility loci between high-grade serous ovarian cancer and female reproductive timing traits, revealing convergent biological mechanisms in immune regulation and chromatin organization that extend the incessant ovulation hypothesis into a genetic framework.

Changqing Jiang, Jingjing Zhang, Linlin Zhang, Xiangyu Wang, Guoliang Li, Xiangyu Liu2026-06-28
🧬 biology

The Role of Gut Microbiome in Mental Health: A Systematic Review with Narrative Synthesis

This systematic review of 32 human studies indicates that while gut microbiome dysbiosis is consistently associated with depression and anxiety and that microbiome-targeted therapies show modest symptomatic benefits, causal conclusions remain tentative and future research requires more rigorous, standardized methodologies to establish definitive causal links.

Sheikh Sharmeen, Sanjoy Biswas, Khodeja Akter, Suhala Sheherin, Rehnuma Abdullah, Md Joni Mia, Borun Chandra2026-06-28
🧬 biology

Hepatitis B virus integrations promote EMT via upregulation of PAK3 expression in HepG2.2.15 cells

This study demonstrates that Hepatitis B virus integration, specifically at the chrX:111,009,033 site within the PAK3 gene, upregulates PAK3 expression to induce epithelial-mesenchymal transition and enhance metastatic potential in HepG2.2.15 cells, thereby promoting hepatocarcinogenesis through the activation of JAK/STAT and MAPK signaling pathways.

Chao Huang, Haisen Yin, Mengjuan Lin, Lei He, Kunqiao Hong, Xiufang Dai, Rui Zhou, Peng Ruan2026-06-28