4656 papers
This study utilized in silico drug repurposing and rational hybrid design to identify and develop potent falcipain inhibitors for malaria treatment, demonstrating that combining high-affinity non-antimalarial compounds like Telithromycin with existing antimalarials yields superior hybrid candidates, particularly TELI-ATOVA, which warrants further experimental validation.
This single-case study demonstrates that exposure to microgravity induces significant, subclinical alterations in human phonation—specifically marked reductions in vocal stability and contact quotient alongside increased jitter—likely caused by systemic fluid shifts and altered respiratory mechanics, thereby highlighting the need for continued monitoring and the potential use of vocal metrics as a health indicator for astronauts.
This paper presents a mechanically stabilized abdominal imaging platform that enables high-resolution, longitudinal intravital visualization of the omental metastatic niche in live mice by isolating the tissue from respiratory motion while preserving physiological dynamics, thereby overcoming the limitations of current methodologies for studying peritoneal cancer progression and immunotherapy responses.
This study demonstrates that a 64Cu-labeled anti-CD38 nanobody (WF121) enables specific, high-contrast immuno-PET imaging of CD38 expression in multiple myeloma xenografts, validating its potential as a non-invasive companion diagnostic for guiding targeted therapies.
This study demonstrates that while chronic stress, aluminum chloride exposure, and tramadol administration all impair spatial memory in animal models, the combination of hormonal loss (ovariectomy) and environmental toxicity (aluminum chloride) induces the most profound hippocampal dysfunction, whereas stress accelerates memory loss but shows a complex kinetic response.
This study demonstrates that the probiotic *Bacteroides intestinalis* AM-1 ameliorates acute liver failure by rewiring glutathione and bile acid metabolism to restore mitochondrial homeostasis and suppress necro-apoptosis, thereby significantly reducing liver injury and mortality.
This pedigree-anchored systematic review and meta-analysis demonstrates a robust, directionally consistent association between mitochondrial macro-haplogroup U and Multiple Sclerosis risk across Arab, Iranian, and European populations, yielding a pooled odds ratio of 1.91 despite the limited power of the initial Arab discovery cohort.
This study investigates the differential placental immune mediators in pregnant women with preeclampsia, with or without SARS-CoV-2 infection, revealing that specific alterations in immune molecule expression at the maternal-fetal interface may explain why preeclamptic women infected with COVID-19 exhibit a less severe clinical presentation compared to those with COVID-19 alone.
By integrating Mendelian randomization with multi-omics transcriptomic and proteomic data, this study identifies NPC2, PCDH12, and IL10RB as novel downregulated therapeutic targets for spina bifida and proposes tamibarotene as a potential drug candidate.
This study identifies TRIM36 as a critical positive regulator of septic inflammation that drives TLR4 signaling by catalyzing K63-linked ubiquitination of TAK1, thereby promoting NF-κB activation and cytokine production, which suggests its potential as a therapeutic target for sepsis.