4656 papers
This study establishes generic allometric regressions for organ mass and blood flow across mammalian species, demonstrating their high predictive accuracy and revealing that scaling in hyperperfused organs depends on both body and organ mass to support cross-species pharmacokinetic extrapolation and the integration of biological traits.
The study identifies a class of oncogenic mutations termed BREADCROMs that disrupt lineage differentiation and promote tumorigenesis by inducing broad DNA methylation alterations that lock stem cells in a constrained, intermediate state resistant to both reprogramming and terminal differentiation.
This study validates the use of insertable cardiac monitors to establish the first long-term heart rate baseline for conscious, unrestrained jaguars, revealing that activity, time of day, and feeding schedules are primary drivers of their cardiac rhythms.
This study demonstrates that dysfunction of basal forebrain parvalbumin neurons drives Alzheimer's disease progression by disrupting cortical network oscillations and directly exacerbating hippocampal pathology, ultimately leading to cognitive impairment.
This study identifies the glycosyltransferase B3GNT3 as a novel prognostic biomarker in lung adenocarcinoma that links Porphyromonas-associated microbial dysbiosis to mTORC1 pathway hyperactivation and adverse patient outcomes through integrative multi-omics analysis and experimental validation.
By integrating spatial transcriptomics and single-nucleus RNA sequencing, this study reveals that genomic imprinting in maize endosperm is highly cell-type specific, with the majority of imprinted genes restricted to single cell types and a predominance of paternally expressed genes, suggesting that post-fertilization differentiation shapes the spatial and cellular complexity of this epigenetic phenomenon.
This study demonstrates that kolaviron, a natural biflavonoid from *Garcinia kola*, effectively protects against atrazine-induced hepatorenal injury in rats by mitigating oxidative stress, inflammation, apoptosis, and autophagy through the modulation of NF-κB/Cox-2/IL-1β and Beclin-1/LC3-II signaling pathways.
This study demonstrates that vaccine reactogenicity is driven by an interaction between specific HLA genotypes (notably HLA-A*03:01) and innate inflammatory responses, serving as a clinically observable correlate of enhanced protection against SARS-CoV-2 infection.
This study demonstrates that replacing riparian tropical dry forest with oil palm monoculture in northern Colombia significantly reduces harvestmen abundance, richness, and diversity while driving compositional homogenization, thereby identifying these arachnids as sensitive indicators of riparian microhabitat degradation.
This study demonstrates that an 8-week combination of endurance training and MitoQ supplementation induces synergistic increases in PGC-1α and PDK4 gene expression in young rats and partially restores these responses in aged rats, though the magnitude and nature of the interaction vary significantly by age and specific gene target.